Barely Significant

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highly significantp < 0.00010.0× alphaqualifiedgold
The primary endpoint at week 24 showed a highly significant reduction in gadolinium (Gd)-enhancing brain MRI lesions with ocrelizumab treatment vs placebo; the number of Gd-enhancing lesions was 89% ( p < 0.0001) lower in the 600 mg ocrelizumab group than in the placebo group, and 96% ( p < 0.0001) lower in the 2000 mg group [ 3 ].
highly significantp < 0.00010.0× alphaqualifiedgold
We found a highly significant lower frequency of SARS-CoV-2-specific TNF+CD4+ and CD8+ T cells ( p < 0.0001) correlated with increasing BMI category (Supplementary Table 11 ; ANOVA for general linear models with adjustment for covariates), as well as trends of lower SARS-CoV-2-specific IL-2+CD4+T cells and higher CRP ( p ≤ 0.014, q < 0.156).
highly significantP < 0.00010.0× alphaqualifiedgold
The levels of eight cytokines showed a highly significant correlation with the degree of small bowel mucosa damage according to the Marsh classification: IL-27 ( r = 0.46; P < 0.0001), sIL-2Ra ( r = 0.41; P = 0.0005), IL-15 ( r = 0.40; P = 0.0005), IL-8 ( r = 0.40; P = 0.0004), IL-5 ( r = 0.30; P = 0.01), IP-10 (IFN γ inducible protein 10 or CXCL10) ( r = 0.27; P = 0.02), sTNFRII ( r = 0.26; P = 0.03), and MIP-1 β ( r = 0.25; P = 0.03).