Excerpts

There was also a positive, highly significant association between older age and improvement of baseline social functioning, i.e., per year of age, social functioning would increase by 53% (ß = 0.53, p = 9.53 × 10 −5 ); see Figure 4 .

This increase in cervicovaginal disease severity was highly significant ( P = 9.53 × 10 −5 ) compared to mice infected with MmuPV1 but not treated with UV and E2.

We observed minimal but statistically highly significant differences in cfDNA yields between blood samples stored in EDTA or PAXgene tubes (p=0.000097, paired t-test).

All the probes shown in Figure 2 were highly significant with p-values <9.77E −05 .

Interestingly, in our study, both the pangenome- and SNP- based GWAS analyses indicated that the rimI gene, encoding a ribosomal protein S18-alanine N-acetyltransferase, is linked to clinical traits displayed by the isolates, as indicated by a significant pangenome locus (adjusted p-value < 0.00033) and two highly significant SNPs (adjusted p-value < 9.7979e-05).

Sensitivity analyses’ results In addition to the IVW method, the WM method also showed a marginally positive significant association between total lipids in S.HDL.L and UC (OR = 1.201, 95% CI: 0.994–1.451, P = 0.052) [ Table 2 ], although this association did not reach statistical significance at a Bonferroni-corrected threshold ( P < 9.94 × 10 −5 ).

In contrast, a previous meta-analysis of GWAS with a comparable sample size (∼ 30,000) reported that SNP rs1831554 within this locus showed marginal significance for femoral neck BMD ( P = 9.94 × 10 −5 ) and lumbar spine BMD ( P = 1.41 × 10 −4 ) [ 8 ].

Monte Carlo simulations show that LAD formation on preexisting GADs is not random, but is rather highly significant ( P = 9.98 × 10 −5 ) ( Fig. 5 B).

Intriguingly, the let-7g targets showed highly significant enrichment for association signal ( p = 9.99 × 10 −5 ) and magnitude signal ( p = 3 × 10 −4 ) in comparison with non-target genes based on quartile categorization.

Group classification using the support vector machine (SVM) Overall, the set of 12 variables achieved good classification accuracy (81%), sensitivity (78%), and specificity (85%), and each of these were highly significant compared to chance simulations using permutation tests (accuracy P = 9.99 × 10 −5 ; sensitivity P = 9.99 × 10 −5 ; specificity P = 6.99 × 10 −4 ).

The dissimilarity metrics, measured separately with Bray-Curtis, Jaccard, and Jensen-Shannon (JSD) indices with 10,000 permutations, were all highly significant (PERMANOVA, p = 9.999e-05), representative of the centroids being different between the two groups.

Beta diversity among sampling years was highly significant for all bird species ( n = 167, R = 0.175, P = 9.999e −05 ; Supplementary Fig. 8c ) and when subsetting by only sandhill cranes ( n = 122, R = 0.106, P = 9.999e −05 ), but not when subsetting for only non-crane bird species ( n = 45, R = −0.70, P = 0.905).

The deviations between the torsional spaces covered are highly significant for almost all maps (p-value < 0.0001), with significantly higher mean distance-to-centroid for all MD maps (see also Additional file 1 : Table S4).

Accordingly, spearman correlations between p-S65-Ub and PRKN protein levels in WT, Prkn +/- , and prkn -/- brains were positive and highly significant ( r = 0.72, p < 0.0001) (Fig.

The incidence rate showed a rapidly increasing trend from 1975 to 1987, with an APC of 3.3% (95% confidence interval [CI] = 2.8–3.9%, P < 0.0001), while this increase slowed from 1988 to 2001 (APC = 0.8%, 95% CI = 0.4–1.1%, P < 0.0001), and was followed by a decreasing trend from 2002 to 2016 (APC= −0.7%, 95% CI= −0.9% to −0.5%, P < 0.0001).

Note that MFI is displayed on a logarithmic scale, and the effect of all three anti-cytokine antibodies was highly significant (p < 0.0001) for IFN-γ.

When the analysis was performed according to the lesion size, a statistically significant difference was noted in the detection rate of DWI and T 2 -TSE for both types of metastatic lesions (lesions with size <10 mm and lesions with size >10 mm), and the difference was highly significant ( p < 0.0001) for lesions <10 mm in which DWI detected 38 more lesions compared with T 2 -TSE.

Random simulations yielded an average of 55.4 overlaps, and the bootstrap p -value was highly significant ( p < 0.0001; Table 1 ).

Temperature effects on mycelial growth of different Fusarium species According to ANOVA, the average effects of different temperatures on fungal radial growth of Fusarium species were highly significant at P < 0 . 0001 .

Temperature (T) and aging time (D) showed highly significant effects ( p < 0.0001), while humidity (H) also demonstrated a significant influence, with all three main factors falling below the 0.05 threshold.

The model was highly significant ( P < 0.0001) and showed an improved R 2 m of 0.3180 (Fig. 4 , right; Supplementary Table 6a ), supporting an immunometabolic contribution to clinical severity within EBV-naïve/low participants.

Results Inspection of Tuta absoluta infestation At all sampling times the parameters scored showed highly significant differences between the T and S lines ( P < 0.0001, t-test, Table 1 ).

14 of the 23 proteins correlated significantly with estradiol whereof sTNFRSF4, -6B, TNF, TNFSF14 and sTNFRSF10B being highly significant, p<0.0001, Figure 5B .

GradCAM which demonstrated that the sensitivity ( p -value < 0.0001 and p -value < 0.0001 respectively) was significantly different however specificity between HR-CAM and Zhou’s CAM did not vary ( p -value > 0.05) conversely between HR-CAM and GradCAM it was highly significant ( p -value < 0.0001).

Highly significant effect ( p < 0.0001) of treatment and interaction on enzyme activity was recorded (Table 1 ).