Excerpts

Across the significant surprise effects, this yielded a highly significant positive correlation (r = 0.75, p < 0.00005; Fig. 2C ).

While there was no significant effect of blindsight status (positive or negative; F = 2.6, p = 0.13), there was a highly significant effect of lesion side (ipsilateral or contralateral; F = 35.7; p < 0.00005) and interaction, suggesting a differential effect of the lesion in the two patient groups (F = 5.1; p = 0.04).

The difference between the survival curves for of the high and low risk phenotypes is highly significant (p < 0.00005).

When the same analysis was run three times, comparing the intention-offloading/nonoffloading task with the other tasks one by one, the intention-offloading/nonoffloading predictor was always highly significant, t (990) > 4.0, p < .00005, but none of the other three was, t (990) < 1.35, p > .17.

We observed highly significant associations between CD40 expression and the rs4810485 genotype in all B cell subsets (patients: P ≤ 5.10 × 10 −5 , controls P ≤ 4.09 × 10 −6 ), with each copy of the multiple sclerosis risk allele rs4810485*T corresponding to lower CD40 cell surface expression levels ( Figs 1 and 2 ).

Especially, apparent is the highly significant decrease for the mean head‐directional firing rate ( Z 65 = −4.053, P = 5.1e‐05) and its loss in correlation between sessions (Fig. 4 f).

Of note, BABAM1 is the most highly significant CNV associated locus following full statistical correction of population stratification (p = 5.16×10 −5 ).

The ANOVA detected a highly significant ( F (1,66) = 18.73 , p = 5.2 e – 05) interaction between the carrier factor and the sonicated LGN side (left or right LGN).

These genes showed an extremely significant lower level of nucleotide diversity and Tajima’s D values ( P = 5.22E-05 and 1.23E-30, respectively, Mann–Whitney U test) compared with other genes in the genome ( fig. 1 A ), suggesting a potential selection effects on the divergence observed here.

Additionally, a locus on chromosome 14, within a cluster of SNPs showed a trend toward significance (p = 5.24E-05).

pruinosus population, the overall results of the proportion of individuals (pc) showed a highly significant treatment effect (χ 2 = 29.338, df = 6, p = 5.25 × 10 −5 ), indicating strong behavioural modulation in response to LDPE leachates ( Table 1 ).

The difference in errors between shallow (LIPd: −0.2 ± 1.4% [P = 0.86]) and deep (LIPv: 15.7 ± 3.4% [P = 6.1e-05]) injections was highly significant (P = 5.3e-05, two-sided permutation test).

Notably, Cryptosporidium was detected exclusively in Chinese blue-tailed skinks, with its prevalence showing a highly significant difference between the two hosts ( p = 5.32 × 10 −5 , Fisher’s exact test).

The IVW regression showed a highly significant association between the 11 SNPs used as genetic instruments of exposure and risk of developing MM (coeff = 1.175, 95% CI 0.61–1.75, P = 5.38 × 10 −5 ), whereas the MR-Egger regression showed a statistically non-significant association (coeff = 0.532, 95% CI −1.16 to 2.22, P = 0.538), although in line with IVW regression, with the intercept slightly, but not significantly, different from zero (intercept = 0.06, 95% CI −0.09 to 0.20, P = 0.428).

Trends of Antipsychotic Prescriptions The rates of antipsychotic monotherapy in 2001, 2006, 2011, 2016 and 2021 were 32.0%, 33.7%, 32.8%, 37.6% and 41.5%, respectively, with an increasing trend (χ2 = 16.3, df = 1, p = 5.4×10 −5 ) ( Table 1 ).

The highly significant association is replicated ( P = 5.4 × 10 −5 ) with an estimated OR of 1.9 (95% CI, 1.2-2.6).

In Cox regression, patients with multihit abnormalities had a 2.89-fold increased risk of death compared with those with wild-type TP53 (95% CI, 1.88-4.43), and those with single-hit abnormalities had a 1.63-fold increased risk of death (95% CI, 0.91-2.91) compared with those with wild-type TP53 ( Figure 2 D), with a significant trend in the HR as the number of TP53 abnormalities increased (likelihood ratio test, P = 5.42 × 10 −5 ).

Patients with multi-site cancers demonstrated a notably higher cumulative incidence of irAEs compared to melanoma patients, with the difference being highly significant ( P = 0.0000546).

While the enrichment of the mTOR signaling KEGG pathway (hsa04150) was not statistically significant, the enrichment of genes from a manually curated mTOR signaling network [57] was highly significant in our dataset (p = 5.5×10 −5 ).

When GWAS was performed in the 113 11q-deletion cases and 282 controls (78 undeleted 11q and 204 MNA neuroblastomas, Methods) of European-American ancestry, the 11q22.2 locus was still nominally significant (rs10895322, P = 5.50 × 10 −5 , OR = 2.811, logistic regression test, Supplementary Table 6 ), indicating a unique and independent role of the 11q22.2 locus in the 11q deletion cases.

Lists of representative genes involved in particular GO terms in each contrast are presented in Additional file 5 . “Luteal regression over luteolysis”: GO terms having highly significant association with genes upregulated in the luteal regression group are: extracellular matrix ( p = 5.52e-05) and matrix organization ( p = 0.001), steroid hormone mediated signaling ( p = 2.29e-04) and steroid hormone receptor activity ( p = 1.63e-04), regulation of gene expression ( p = 7.40e-04), negative regulation of transcription from RNA polymerase II promoter ( p = 5.02e-05), and regulation of transcription, DNA-templated ( p = 2.45e-04), as well as positive regulation of epithelial cell proliferation ( p = 3.4e-03).

The comparison of patients carrying TP53 mutation ( TP53 -mut) to patients without TP53 mutation ( TP53 -wt) revealed a highly significant association between TP53 mutations and higher age ( P =5.54 × 10 −5 ; median age at sampling 69.3 for TP53 -mut and 62.4 for TP53 -wt; Figure 2a ).

We discovered that there was a highly significant over-representation of genes involved in development amongst spatially clustered T-DMRs that are hypomethylated in MBCs versus CVS (p = 0.00005574).

Compared to results from the primary epigenome-wide mediation models, the mediation effects of CpGs across all cardiometabolic outcomes were slightly attenuated after accounting for smoking; however, all CpGs remained nominally significant (p < 5.6E-05).

All pairwise comparisons between groups did not reach statistical significance except for the comparison of PR interval by age group (ANOVA P = 5.6E-05).