Excerpts

Symptom prevalence The most frequently reported symptom among patients with uterine isthmocele was AUB, observed in 45 cases (78%), which showed a highly significant association (p = 0.00003).

Within the case group, a Jonckheere–Terpstra test for trend (based on 100,000 permutations) revealed a highly significant increasing trend across the three age strata (puppy, juvenile, adult; JT = 166.5, p = 3 × 10 −5 ) with the median VBI increased from 0.48 (puppy) to 0.55 (juvenile) and 0.57 (adult).

In these pairs, a slightly smaller but still highly significant difference was found, again with the luteus coding sequences associated with higher redness ( t = 4.4855, df = 65, p = 3.03 × 10 −5 ).

Serum FSH was elevated about two-fold (from 88 to 208 ng/ml) with a highly significant p-value (p = 3.07 x 10 −5 ), and LH was elevated about eight-fold (from 0.35 to 2.6 ng/ml), also with a significant p-value (p = 0.014; Fig 10C and 10D ).

In ER-positive patients, highly significant differences between patients with high vs. low CYP19A1 expression were observed with respect to OS ( P = 3.1 × 10 −5 ; Fig. 4 d), DFS ( P = 2.1 × 10 −4 ; Fig. 4 e), and MFS ( P = 1.5 × 10 −6 ; Fig. 4 f).

4a , the difference between groups was highly significant (Kruskal-Wallis, P = 3.107e-05).

This represents highly significant enrichment compared to such variants from gnomAD v2.1 (23 of 958 variants; one-sided Fisher’s Exact Test p -value = 3.15 × 10 –5 , odds ratio = 39.8).

By the 45th day, the group administered with a low dose exhibited significantly elevated L-carnitine levels relative to the control group ( p = 0.0129), whereas the high-dose group not only exceeded the low-dose group ( p = 0.013) but also demonstrated highly significant differences to the control group ( p = 3.15 × 10 −5 ). 3.2.

The loci 25,684,587–26,791,233 in the same chromosome showed borderline significance ( p = 3.16x −5 ), however, this significance did not survive the Bonferroni correction (Table 2 ).

The assigned thresholds were then validated by examining the association between immunostaining scores of the HER-2 gene (HercepTest, DAKO, DK-2600, Glostrup, Denmark) and copy number states, that is, gains, no change and deletions, which was found to be highly significant (Pearson's correlation, r = 0.53, P = 3.2 × 10 -5 ).

In the itpr mutant condition 50 down-regulated genes cluster in the mitochondrion ( Fig 2 ; CC) and a highly significant number (P = 3.2E−5) have the molecular function (MF) of oxido-reduction.

The difference of S nontrem between pretreatment (−0.097) and at 4 years and beyond (1.197) was highly significant ( p = 3.22e‐05), whereas that of S trem was not (0.017 vs. 0.068; p = 0.73).

The difference is highly significant ( P = 3.3 × 10 −5 , Poisson distribution).

Among the 1509 successfully imputed SNPs in the SNCA locus, the strongest association was with rs2301135 (chr4:90,758,389, p = 5.68 × 10 −5 , OR = 1.40, minor allele C) and remained nearly significant after correction (threshold p < 3.3 × 10 −5 ) using conservative multiple test assumptions of independent SNPs.

35 , 36 In addition, the metaboQTL (lead SNP: rs12118651, N = 1,981, p = 3.52 × 10 −15 ) for kynurenic acid was confirmed, while previous studies have reported marginally significant results of this signal in urine (EUR, N = 1,672, p = 3.30 × 10 −5 ), 37 serum (EUR, N = 1,960, p = 4.52 × 10 −6 ), 8 and blood (EUR, N = 86,507, p = 5.41 × 10 −9 ). 38 This novel signal among EAS might be attributable to the specificity of race or the relatively large sample size.

Another nearby gene, PPBP (encoding Pro-Platelet Basic Protein, also known as CXCL7), was also up-regulated in convalescent samples, although it did not quite reach significance at 1% FDR (nominal P = 3.3 × 10 -5 , Benjamini-Hochberg adjusted P = 0.016).

This highly significant overlap (odds ratio = 45.9, P < 3.3 × 10 −5 , permutation test, 30,000 times) provides an independent confirmation of our results.

(iii) Most of the disease LD blocks (67 %) included a single moderately significant disease-trait-associated marker (3E-08 < P < 3.3E-05).

Nevertheless, the association of rs1363713 with AF trait was highly significant ( P =3.34 × 10 −5 ), but not as significant as the CNV.

Among the 13 genes in which LGD strict variants were detected, only RET displayed nominally significant enrichment for rare damaging variants and passed the burden test ( P = 3.35E-05, FDR = 0.00047, other data not shown).

When the number of trophic niches occupied by members of clades was used in this model in place of the number of habitat types, we again found a highly significant result (multiple PGLS, p = 3.365 × 10 −5 , F = 14.62 on 2 & 29 d.f., adj.R 2 = 0.4523, N = 34).

rubidus collected from dung quadrats than those lacking dung, a highly significant difference ( p = 0.0000339, W = 4.15, df = 1, p < 0.01).

The first method reported highly significant values for Pagel’s lambda statistic (λ = 1.002, p = 3.4 × 10 -5 ) ( Pagel, 1999 ), and Blomberg’s K statistic ( K = 1.609, p = 0.001) ( Blomberg et al., 2003 ), indicating in both cases a strong phylogenetic signal for diploid number ( Figure 4A ).

Determination of Photoinhibitory Activity of Eosin Y and Green LED Light Using the Statistical Experimental Design The results in Table S1 (ANOVA) demonstrated that this mathematical model is highly significant ( p = 0.000034) and did not show lack of fit ( p = 0.401258).

We found a highly significant - more than 25% - increase in this measure for PCP-treated rats compared to SAL-treated controls (Fig. 2f , F[3,55] = 9.59, P = 3.44 × 10 −5 ; SAL, 0.72 ± 0.02, PCP, 0.91 ± 0.04, P = 1.0 × 10 −4 ), which was fully rescued by acute D-serine treatment (Fig. 2f , PCP + D-serine, 0.75 ± 0.02, vs.