Excerpts

Two further general population cohorts, KORAF4 and SAPHIR confirmed the association, and a meta-analysis of all three cohorts (11,258 individuals) was highly significant (p = 1.3x10 -5 , OR = 7.46).

Supporting our in vitro findings, analysis of REs in metastatic CRPC tumors revealed a highly significant negative correlation ( r = −0.697, P = 1.3 × 10 −5 ) between levels of SUV39H1/H2 and MDA5-binding repeat RNAs in patients exposed to the antiandrogens Enz or abiraterone ( Fig. 5 C ).

A meta-analysis of all three cohorts (11,258 individuals) was highly significant ( p = 1.3 × 10 −5 , OR = 7.46).

Global Moran’s I analysis at the village level demonstrated weak-to-moderate but highly significant positive spatial autocorrelation of Q fever seroprevalence (Moran’s I = 0.15, Z = 4.3, p = 0.000013).

GO analysis revealed highly significant clusters related to angiogenesis ( p = 1.32 × 10 −5 ) and vasculature development ( p = 1.01 × 10 −7 ).

Survival analysis based on the model risk score demonstrated a highly significant difference (P = 1.363e-05) in the training cohort ( Figure 6C ).

Focusing on cell adhesion, the focal adhesion pathway displays a small but highly significant positive association, which was detected in the liver ( p = 1.39 × 10 −5 ) and kidney ( p = 7 × 10 −4 ), and for cell adhesion molecules associations were found in the liver ( p = 9.71 × 10 −7 ), brain ( p = 0.02) and kidney ( p = 2.70 × 10 −6 ).

The gene × gene interaction terms were highly significant, with VPS45 _KD × C1orf54 _KD ( β = 0.26, p = 1.4 × 10 −5 ) and VPS45_ KD × lncRNA _KD ( β = 0.16, p = 6.7 × 10 −5 ) positively correlated with the SNP editing effect ( Figure 6 J).

random cross-observer comparisons was highly significant (rank sum test; p = 1.4 × 10 −5 ).

The statistical model revealed a highly significant template effect ( DoF = 4, F = 7.08, p = 1.42 × 10 −5 ).

The interaction network between the DAPs was highly significant ( p < 1.43 −5 ), indicating that the DAPs might be biologically relevant.

The random effect of rs29232 exhibited a highly significant P value of 1.90 × 10 −16 (OR = 1.47, 95 % CI = 1.34–1.61); however, the random effect of rs3129055 ( P = 1.43 × 10 −5 , OR = 1.28, 95 % CI = 1.14–1.42) did not exhibit genome-wide significance (<10 −7 ).

Together, the association between lncRNA upregulation and OS was highly significant (p = 1.432e-5) (Figure 2C ).

Similarly, the category “inflammatory response” is also highly significant among LASSO and ELASTIC NET results ( p = 1.44E−05).

Conditioning on the genotype of rs17646946, rs499697 still showed nominally significant association ( P = 1.46e-5) with hair curliness, confirming previous findings.

Ego-Dissolution Inventory (EDI) and Mystical Experience Questionnaire (MEQ) A paired comparison using the EDI revealed highly significant larger total scores for DMT compared to placebo ( T = 6.98, df = 12, p = 1.47e -5 , Cohen’s d = 2.67).

The association of rs3815087 remained highly significant even after correcting for multiple comparisons, both at allelic (FDR corrected p = 1.48 × 10 −5 ) and genotypic levels (FDR corrected p = 2.05 × 10 −5 ) while for other SNPs, this association was lost after multiple corrections.

An extremely significant threshold of P < 1.48 × 10 -5 was used to determine that a total of 213 SNPs were associated with cold tolerance (data not shown).

Lupus nephritis was more common in Subgroup 2, though it was of borderline significance because age was added as a covariable, which was a significant component of the model ( P = 1.5 × 10 −5 ).

Both CCL17 ( Figure 1A ) and CCL18 ( Figure 1B ) expression were highly significant when analyzed in rank order based on Ridley-Jopling classification (non-parametric trend test, P = 1.5×10 −5 and 3.0×10 −8 , respectively).

This hypergeometric analysis indicates that the 4.1 fold greater enrichment in the RAG/CsNp genes was highly significant (p = 0.000015) whereas there was no overall change in growth factor receptor genes (-1.1 fold, p = .42) and significantly fewer genes were found in the apoptosis gene group than expected by chance alone (-2.2 fold, p = .02).

Notably, we also observed an enrichment for CD56+ NK cell genes among nominally significant underexpressed genes in participants’ class I mutations (FDR p = 1.5 × 10 −5 ) ( Figures S5 A and S5B).

Strong and extensive pairwise LD was observed among highly significant SNPs around AX-177640219 ( p -value = 0.000015) on chromosome Araip.B08 from the 12,629,161 to 13,029,161 bp region ( D’ > 0.80) in which D’ varied from 0.036 to 1 ( Figure 5 d and Supplementary Table S5 ).

Conversely, all individual variants identified in our analyses showed directionally consistent effects in a meta-analysis of two European-ancestry studies of extreme longevity, and a test of association of a polygenic risk score of the variants was highly significant in the longevity dataset (p < 1.5 × 10 −5 ).

Case-control genotyping and association tests in the entire GWAS discovery cohort (n = 44) showed highly significant association of the IAR phenotype with FKBP6 SNP g.11040315G>A ( P = 1.51E-05), and significant association with SNP g.11040379C>A (p.166H>N; P = 0.004) ( Table 3 ).