The similarity in prognostic group assignment was highly significant ( p <10 −5 by Chi-square test).
Excerpts
The overall effect of surgery compared to sham surgery was highly significant (SMD 0.34, 95% CI 0.20 to 0.49; p<0.00001), while heterogeneity was large (I 2 =67%, p<0.00001).
When 29 studies containing 4,390 patients who had received radical surgery (I–III) were considered, highly significant heterogeneity was detected ( χ 2 =92.48, P <0.00001; I 2 =70%).
There was a strong positive correlation between DAO and histamine levels in all the groups that was statistically highly significant ( p = 0.00001) (Table 6 ).
Loci harboring marginally significant evidence for association at P <10 −5 were examined for independent signals via regression analyses in PLINK. 16 A term was added to the regression model including the lead SNP as a covariate, and SNPs within the same candidate gene, or ±200 kb if the candidate gene region was <200 kb, were evaluated for maintaining array-wide significance.
Also, the random effect of study was highly significant for the half‐life analysis ( p < 0.00001), but there was no significant random effect of study for the percent recalcitrance model ( p = 1).
S3C ), there was a highly significant difference between all groups when clustered by degree of substrate consumption (Kruskal–Wallis p value <0.00001; Fig.
The χ 2 results show that likelihood ratio statistics are highly significant ( P < 00001) suggesting that the model has a strong explanatory power.
Inter-rater reliability was highly significant (Cohen's κ = 0.62; Z = 19.1; P << 0.00001; number of errors = 90).
The main effect of the post-error was highly significant ( F (1,37) = 204.6; p < 0.00001) indicating that response time increased after errors in a stop trial (Fig. 3a : the difference between the after-error and after-correct trials).
To lend further support to the relationship between hepatic inflammation and TG levels in the liver, there were highly significant positive correlations between hepatic TG levels and TNFα (P < 0.00001), MCP1 (P = 0.0001), IL6 (P < 0.001) and IL1β (P < 0.00001) protein levels.
Pre-saturation of EGFR on A431 cells with an excess of both non-labeled ZEGFR:2377 and cetuximab caused a highly significant (P<1×10 −5 ) reduction of 89 Zr-DFO-Z EGFR:2377 binding to the cells.
The main factor Language was highly significant, F (1, 33) = 98.69, p < 0.00001, reflecting the overall better performance of Tashlhiyt than French participants.
This trend is highly significant ( p < 1 × 10 −5 ; two-sided permutation test).
However, the highly significant differences in sputum conversion ( P <0.00001) corresponded to only slight differences in the conversion rates (86.6% vs. 84.3%).
Genome-wide significance was the accepted P < 5 × 10 −8 while marginal significance was P < 1 × 10 −5 .
3.2 Response to ETI therapy initiation Effects of ETI therapy assessed with averaged CFAbd-day2day © responses revealed a highly significant decrease in the median total score ( p = 0.00001).
Correlative analysis between the overlap score of Kgp and RgpB conducted on the pooled control and PD cohorts revealed a strong and highly significant correlation (Fig. 1k ; r = 0.864, p < 0.00001).
The pre- and post-VAS values were compared and statistically highly significant difference ( P < 0.001%) in mean VAS and clinical scores was observed.
In the ACS patients, the bleeding rate showed a highly significant difference between the short DAPT vs . standard DAPT, with a risk ratio 0.59 (95% CI 0.47-0.74; z=4.56, p=0.00001) (Fig. 4A ).
The standard post-operative treatment in most early trials was CMF polychemotherapy (cyclophosphamide, methotrexate, and 5-fluorouracil), but recent evidence suggests that there is a small but highly significant further survival benefit with anthracycline-based regimens (RR=0.89; 2 P <0.00001) ( EBCTCG, 2005 ), and these have become widely accepted as standard adjuvant chemotherapy.
However, the test results for subgroup differences were highly significant (Chi 2 = 49.43, df = 1, p < 0.00001), suggesting a strong gene–diet interaction.
The difference was highly significant (p < 0.00001), indicating that surgery provides faster and better functional recovery.
At 0% the low α-diversity of phototrophs was highly significant to diversities at 20% (June) (t = −8.85, df = 12, p < 0.00001 ) and at 45% (December) intermittence (t = −8.4, df = 21, p < 0.00001 ) ( Table S5 ).
The patient is assigned the high or low risk of relapse category if the score is ⩾2.41 or <2.41, respectively, with highly significant differences in RFS ( P <10 −5 ) and OS ( P <10 −5 ) between both groups.