Excerpts

The log 10 Bayes factors recovered under each substitution model exhibit very highly significant linear relationships ( r 2 > 0.99, p < 0.00001 in all cases) and are hence independent of the amino acid substitution model employed (electronic supplementary material, S7).

The overall effect was highly significant (Z = 12.27, p < 0.00001), supporting the robust efficacy of the treatment in reducing the uterine size ( Figure 5 ).

Interestingly, we found that the ASA difference between functionally critical and non-critical sites involved in catalytic or binding activity in our data set is not statistically significant ( P > 0.08), whereas the difference of dfi between these sites is highly significant with P < 0.00001 as also shown for residues located in loops ( Fig. 3 B).

Mean linearized ITs of the ALDVICO to all pathogen races of the same species were positively correlated with one another and highly significant (P< 0.00001) ( Supplementary Figure S4 ).

The difference in infection rate was highly significant (p<0.00001), and the odds of a patient with colonisation having a subsequent infection was almost as high as 10:1 (OR (95%CI): 9.6 (2.7-34.0)).

Using fixed-effects model, the results showed that the patients with hypothyroidism had a marginally significant reduction in CI compared with healthy controls (WMD=-0.53, 95%CI[-0.65, -0.41], P <0.00001), and heterogeneity analysis showed large heterogeneity (Tau2=0.21, Chi2=44.02, P < 0.00001, I 2 = 93%).

The positive relationship between φ and geographical distance was statistically highly significant (Mantel test, 100000 randomisations, r = 0.375, P = 0.00001), also when corrected for beetle phenotype (Partial Mantel test, 100000 randomisations, r = 0.379, P = 0.00001; see Materials and Methods for comments regarding the value of r of the Mantel test).

Results Nadi Shodhana Pranayama showed a significant decrease in ART (p = 0.01) and Bhramari Pranayama showed a highly significant decrease in ART (p < 0.00001).

An unpaired Student's t -test demonstrated that both combination treatments were significantly different to the appropriate controls, which resulted in an overall highly significant one-way ANOVA test ( P <0.00001).

Finally, infected C57BL/6 mice displayed a highly significant decrease in the abundance of Gastranaerophilales (Fold change = −17.96, p = 0.00001; DESeq. 2) (Fig. 6b ).

The deviation from Hardy-Weinberg equilibrium is highly significant ( P < 10 −5 , Fisher’s Exact Test 40 ) with a complete absence of heterozygotes.

Acquisition was fast and highly significant ( F (2,294) = 183.65, P < 0.00001), reaching 80% of conditioned responses at the last acquisition trial ( Fig. 1 A).

All eligible cases (1,300 cases) Univariate analysis of all cases with complete Mammostrat ® data irrespective of ER status, nodal status or treatment showed a highly significant association between Mammostrat ® score and DRFS (Figure 2b ), between score and RFS (Figure S1D in Additional file 1 ), and between score and OS (all P < 0.00001; Figure S2D in Additional file 1 ).

Relative to the codon frequency of the native DNA, the Mann-Whitney-Wilcox rank-sum analysis of the optimized CDSs shows that two are non-significantly (n.s.) optimized, four exhibit a p value between 1.4E−03 and 7.7E−04, and three are highly significant with a p < 1E−05 (GenScript, GeneArt, COOL).

In contrast, a highly significant positive offset was found for δ 15 N ( V = 378, p < 0.00001), indicating that δ 15 N values were consistently higher by 1.5‰ on average in tooth tissue compared to long bone/rib.

The strength of this dependence between the aCVT and aCrVT is demonstrated by highly significant p-values using a Fisher’s Exact Test of Independence (left p = 0.00001 and right p = 0.00018).

However, supporting a direct, specific role for Fanca during SHM, we observed that the frequency of mutations at A/T residues was significantly reduced in Fanca −/− mice (P = 10 −4 ; Table 1 ), and this reduction was associated with a highly significant (P < 10 −5 ) decrease in the frequency of transitions at these sites ( Table 1 ).

A highly significant correlation (R 2 = 0.9021, p value < 10E-6) was calculated between the two techniques (Figure 7 ).

41 , 42 If these studies had been included, there would be a highly significant ( P < 0.00001) association between chemoprophylaxis and postoperative bleeding. 38 Moreover, a 2016 meta-analysis by Pannucci et al 43 found a higher risk of hematomas ( P = 0.02) in anticoagulated plastic surgery patients, in addition to no significant reduction in VTE risk in plastic surgery inpatients with Caprini scores >8.

In both residue-level and protein-level assessments the improvement in performance of aaRNA over the alternative methods was highly significant ( P -values <10 −5 and <10 −10 , respectively).

When the blind evaluator rated photos, there was a slightly smaller but still highly significant decrease in score (−1.1) from day 0 to day 360, t(36) = −10.712, p < .00001] with no significant decrease in effect from day 60 to day 360 in most patients as can be shown in Figures 2 – 4 below, with the minority of patients having minimal regression, Figures 5 – 7 .

Subgroup analysis of six studies with higher cumulative dose of statin use, defined as statin use over 180 cumulative defined daily doses (cDDDs) or 0.5 years (cumulative duration), showed a trend towards more risk reduction of liver cancer (RR=0.53, 0.36 to 0.79), but with a high degree of heterogeneity (I 2 =90%, p<0.00001; see online supplementary figure S7).

Estimation of the SNP effect from the haplotype effect Under the hypothesis that one SNP of each haplotype was expected to have a major effect on the recorded trait, direct observation of those haplotype alleles that showed a highly significant effect (P < .00001) on one trait allowed to select one SNP where the two alleles showed opposite effects on that trait.

Differences between recordings at 0.3, 0.7, 1.0, 1.3 and 1.7L/s were highly significant as revealed by Friedman test (p<0.00001).

The overall effect was highly significant (Z=4.90, P<0.00001), confirming the effect of supply center management protocols on reducing the incidence of HAIs.