Excerpts

Finally, when correlation values were raised to c = -80% and c = +80% highly significant GC values were obtained (Figure 3A , c = -0.8, GC = 1.056, P < 1 × 10 -6 ; Figure 3E , c = 0.8, GC = 1.073, P < 1 × 10 -6 ).

Both values are highly significant (p-value < 10 -6 ).

We observe a 4-fold enrichment of such ‘clustered’ informative sites, which is highly significant ( p <<10 −6 ).

For the EXP group, student test scores had increased at each stage of testing (post > pretest 2 > pretest 1), and the paired t tests at each stage were highly significant ( p < 10 −6 ).

The difference in reactivity against the same modified food antigens in these two groups was highly significant (p < 0.000001).

The differences among the three classes were highly significant (overall differences tested by ANOVA: F 2,141 = 19.5, P<10 −6 ; pairwise t tests: least significant p value <10 −3 ).

A strong, highly significant correlation between the frequency of tracking interruptions with the right and left hand was found (Pearson correlation, r = 0.834, p<10 −6 ).

Based on the training data (and the additive model unless specified otherwise), we detected 1,758 marginally significant SNPs at p < 10 − 6 ; after removing those in high LD (i.e., correlation > 0.99 ), we had 1,652 SNPs.

These studies reported robust sample sizes, highly significant p -values ( p < 10−6), and statistically significant results in the largest included studies.

Highly significant differences ( P < 0.000001) were observed for both potassium and calcium relative to the other minerals (Fig. 10 ).

The two-way within-subject design ANOVA on WM-GM CNR found a highly significant effect of protocol (F(3,21) = 80.32, p<0.000001) but no significant effect of ROI (F(9,63) = 1.475, p>0.15).

the nascent bond show that all of these active site dynamics are highly significant with p < 10 −6 ( Fig.

Thus whilst there was no difference between males and females in the mean age of diagnosis for individuals homozygous for the more common ARE1 allele (56.5 years vs 56.7 years respectively), males carrying the less common ARE2 allele (heterozygotes and ARE2 homozygotes) had an earlier mean age of diagnosis (55.1 years) compared with females carrying the ARE2 allele (58.6 years) a difference of 3.6 years which was highly significant (p < 0.000001).

Corresponding studies with 89 Zr-DFO-ZEGFR:2377 resulted in 17.7 ± 0.3% (A431) and 23.8 ± 0.2% (MDA468) cell-associated radioactivity. Pretreatment of A431 and MDA468 cells with EGFR specific antibody cetuximab led to a highly significant (<0.3% of total activity; P < 1 × 10 –6 ) reduction of binding of 89 Zr-labeled affibody bioconjugates indicating highly specific targeting properties ( Figure 3 A).

All results were highly significant with p < 0.000001.

The mortality rate for NH white group also demonstrated an increasing trend from 0.132 to 0.196 from 1999 to 2001 (APC: 22.3406; 95% CI, 4.4622 to 39.741; p < 0.000001), with a rise to 0.286 in the mortality rate from 2001 to 2018 (APC: 2.8652; 95% CI, −3.0608 to 3.5123; p = 0.119176), followed by an increase to 0.414 from 2018 till 2022 (APC: 10.7260; 95% CI, 5.725 to 20.0315; p < 0.000001).

For example, a study involving 1001 patients with a highly significant p values < 0.000001 association between risk factors and outcomes may be classified as class I evidence according to the grading criteria of evidence, while another study with the same results in other aspects but only 1000 patients may be graded as class IV evidence.

Box 1 Umbrella review evidence rating by strength of association Convincing Highly significant associations (P<10 −6 ) Cases of n >1000 I 2 <50% 95% prediction intervals excluding the null value Largest study nominally significant (P<0.05) No evidence of small study effects No evidence of excess significance bias Highly suggestive Highly significant associations (P<10 −6 ) Cases n >1000 Larg

Specifically, the group‐average correlation between condition‐specific performance and d’ was 0.97 (SEM = 0.06) and highly significant (T(18) = 32.57, p < 10 -6 ).

The results are highly significant with p < 0.000001.

McNemar Test: χ 2 = ( b − c − 1 ) 2 b + c The McNemar test demonstrated a highly significant difference between the two conditions (continuity-corrected χ 2 = 262 , p < 10 − 6 ; exact binomial p < 10 − 12 , Table 10 ).

However, for intergroup comparison, the difference between the two modes was found to be highly significant in both sedated and awake states if we considered inspiratory hold in PAV+ as PMI ( P = 0.000001 for both states).

Briefly, meta-analyses were considered to be supported by robust evidence if the association was supported by more than 1000 cases, a highly significant association (the random effects model had a P -value ≤ 10 −6 , a threshold that is considered to substantially reduce false positive findings) [ 31 – 33 ], there was absence of high heterogeneity based on I 2 < 50%, the 95% PI excluded the null value, and there was no evidence of small-study effects or excess statistical significance.

The difference between means of traffic exposure groups was highly significant (Wilcoxon test, p < 0.000001).

The analysis of discriminance revealed a highly significant discrimination between diabetic patients and controls (Wilks lambda: 0.27; P < 0.000001).