Excerpts

Even after accounting for phylum identity, the clustering was still highly significant (PERMANOVA P < 10 −6 ).

For consistency, we also examined this relationship using the 1000 Genomes phase II data and found similar highly significant relationship between N e for homozygous SNVs ( P < 10 − 6 ) (Additional file 1 : Figure S1).

Stratification of evidence specific to an umbrella review We performed an umbrella review-level stratification of evidence using modified criteria recommended by Fusar-Poli et al [ 19 ] : Convincing evidence (Class I) when the number of cases (deaths) > 1000, highly significant summary associations (random-effects P < 10 −6 ), no evidence of small-study effects, no evidence of excess significance bias, 95% prediction intervals excluding the null, and not large heterogeneity (I 2 < 50%); Highly suggestive evidence (Class II) when the number of cases > 1000, random-effects

Highly significant differences in the levels of composite biomarkers were found between AD groups and normal controls ( p < 0.000001, one-way ANOVA), whereas differences in the levels of a single biomarker were only significant at the level of 0.001 (Fig. 4a–f and Supplementary Fig. 28 ).

Global analyses identified a total of 2,053 sites with overlapping peaks, and statistical analyses showed that this overlap is highly significant ( Figure 2 B) (p < 10 −6 , calculated using a permutation test with 1.0 × 10 6 iterations).

Box 1 Umbrella review evidence rating by strength of association Convincing Highly significant associations (P<10 −6 ) Cases of n >1000 I 2 <50% 95% prediction intervals excluding the null value Largest study nominally significant (P<0.05) No evidence of small study effects No evidence of excess significance bias Highly suggestive Highly significant associations (P<10 −6 ) Cases n >1000 Larg

Differences between populations accounted for only 6.96% of the variance, but was highly significant ( P < 1.0 * 10 −6 ).

1 a), which is further supported by a low but highly significant genome-wide estimate of genetic differentiation ( F st = 0.0021; p value < 10 −6 ).

One-way ANOVA for repeated measures followed by Tukey post hoc test revealed a highly significant difference ( p < 1 × 10 −6 ) between Fe-treated animals versus the other three groups (Fig. 1 b).

Furthermore, the comparison of the FMCA survival curves for TC and CRISPRa-RPA1 groups using the factorial ANOVA produced a highly significant difference ( p < 0.000001).

Similarly, rs2242652 showed increased TERT expression in the GA genotype compared with the GG genotype, while the AA genotype—despite the smaller sample size—followed the same trend, with highly significant associations ( p ≈ 10 −6 –10 −5 ). 3.9.

A total of 151 genes were regulated by hypoxia in both datasets (Figure 1D ), and a permutation test revealed such an overlap between the two datasets was highly significant ( P < 1 × 10 −6 ; Supplementary Figure S1B ).

The prevalence varied between 18.2 and 50.7 %, depending on locality, and this variation proved to be highly significant (χ 2 = 59.599; P < 0.000001) (Table 1 , Fig. 1 ), suggesting a focal occurrence of borreliosis.

2, Supplemental digital content 3, http://links.lww.com/FPC/B116 for Manhattan and quantile–quantile plots for the total PANSS score, the positive Marder factor score, the negative Marder factor score, and CGI-S, respectively) and 20+ regions including aarF domain containing kinase 1 ( ADCK1 ) that showed a trend toward association ( P <1.0×10 −6 ).

For BRCA2 both ER and grade were highly significant predictors of mutation status, and the interaction of ER and grade was also quite significant (χ 2 = 28.3, 2 df , P <10 -6 ).

The log10-transformed engorged larval weight was a highly significant predictor of the log10-transformed unfed nymphal weight, and the former explained 72.7% of the variation in the latter (Fig. 4 ; regression: F 1, 651 = 1738, p < 0.000001; correlation: r = 0.854, t = 41.859, df = 652, p < 0.000001).

7 ) revealed that the increase in accuracy was highly significant (monkey A: χ 2 = 95.3, P < 10 −6 ; monkey G: χ 2 = 60.6, P < 10 −6 , Chi-Square test).

Despite the relatively small sample size, one SNP was identified with a very significant P -value ( P = 5.5*10 -8 ) and several others were identified that were suggestive of significance ( P < 1.0*10 -6 ).

The difference between ASLs and ASELs means was highly significant ( p < 10 −6 ), and the variances were highly significant different ( p < 10 −6 ).

The CCorA model applied revealed that there was only a single canonical dimension between the two datasets, which was found to be very highly significant ( p <10 −6 , Wilks'-Lambda test); this first dimension corresponded to a canonical correlation of 0.99, which accounted for 67.2% of the total variance.

This effect is small; on average people get about 6% faster and spend about 1% less time buzzing, but highly significant ( p <10 −6 for both metrics, t -test).

6 a) shows similar performance between the NMF and PCA methods, with a small but highly significant trend towards increased values for the NMF method ( p < 10 − 6 , Wilcoxon Signed-Rank test).

GARFIELD reads variants from our GWAS summary statistics using two p -value thresholds: genome-wide significance ( p = 5 × 10 −8 ) and borderline significant ( p = 1 × 10 −6 ) in its analysis.

Within these 47 regions, we also assessed whether the traits that did not have a variant with p < 5 x 10 − 8 , had a moderately significant variant with p < 1 x 10 − 6 ; signals from such traits were also included in our fine-mapping.

A paired t test revealed a highly significant and strong decrease in the mean slope from the EO to EC condition in the combined group of subjects ( T (82) = 5.81, p < 0.000001, Cohen d = 0.64), as well as in the separate groups (TD: T (44) = 3.67, p = 0.0006, Cohen d = 0.55; ASD >85 : T (22) = 3.38, p = 0.0003, Cohen d = 0.71; ASD <85 : T (14) = 3.31, p = 0.005, Cohen d = 0.85; Fig. 2 D).