Excerpts

After ranking the genes in the test and validation sets, we identified a signature of 95 highly significant ( P < 0.000001) differentially expressed genes (FDR = 0), which distinguished tamoxifen treated from untreated breast cancer patients ( Fig. 3 ).

Twenty-five additional independent loci showed moderately significant ( P < 1 × 10 −6 ) associations, nine with endometrial cancer overall, nine specifically with endometrioid histology, and seven with non-endometrioid histology (Supplementary Data 2 ).

McNemar Test: χ 2 = ( b − c − 1 ) 2 b + c The McNemar test demonstrated a highly significant difference between the two conditions (continuity-corrected χ 2 = 262 , p < 10 − 6 ; exact binomial p < 10 − 12 , Table 10 ).

All 157 SNPs with highly significant associations ( P <1 × 10 −6 ) in this region, were in high linkage disequilibrium with rs188686860 and rs115635831 ( r 2 >0.90), and were located proximal (Hg19: 201,717,014-201,995,860) to the CASP8 gene ( Supplementary Table 15 ).

The difference between means of traffic exposure groups was highly significant (Wilcoxon test, p < 0.000001).

showed a highly significant correlation between final VA and the presence of RD (p <10 -6 ) which makes retinal detachment one of the main limiting factors for a favorable visual outcome ( 6 ).

Furthermore, the comparison of the FMCA survival curves for TC and CRISPRa-RPA1 groups using the factorial ANOVA produced a highly significant difference ( p < 0.000001).

6 a) shows similar performance between the NMF and PCA methods, with a small but highly significant trend towards increased values for the NMF method ( p < 10 − 6 , Wilcoxon Signed-Rank test).

1 a), which is further supported by a low but highly significant genome-wide estimate of genetic differentiation ( F st = 0.0021; p value < 10 −6 ).

As expected, we observed a highly significant, positive relationship between metabolic rate and body mass ( R 2 = 0.53, F 1,175 = 193.65, P < 0.000001; log-transformed data).

This file contains highly significant SNPs (P < 1 × 10 −6 ) from the mixed model analysis of the milk minerals and proteins.

Based on the training data (and the additive model unless specified otherwise), we detected 1,758 marginally significant SNPs at p < 10 − 6 ; after removing those in high LD (i.e., correlation > 0.99 ), we had 1,652 SNPs.

Overall, TIN‐signature genes show a highly significant ( P < 10 −6 ) enrichment for proximal SEs at all distance ranges measured (Fig. 5 C).

We concluded that our finding of 33 cases of positive selection on mitochondrial biogenesis genes is highly significant (simulated P < 10 −6 ) and not caused by an expression or sequencing bias.

In confirmation of our hypothesis, there was a highly significant, 9.4-fold, increase in the maximal tetanic force (7.5±0.94 g versus 0.8±0.2 g; p=≤0.000001) elicited by ONS in the engrafted OST group of SOD1 G93A mice at late-stage disease, compared to age-matched untrained SOD1 G93A mice (132.4±6.8 days versus 133±6.9 days; n=7 and 11, respectively; Figure 5C–G and Appendix 1—table 3 ), although OST did not alter contractile rate characteristics ( Figure 5—figure supplement 5A–C ).

Of these, coeliac disease, rheumatoid arthritis, Sjögren's syndrome, and SLE, were classified as having highly suggestive (i.e., p < 1 × 10 −6 , at least 1000 NHL cases, and largest study in the review reporting a nominally significant result) or convincing evidence (i.e., p < 1 × 10 −6 , at least 1000 NHL cases, largest study in the review reporting a nominally significant result, minimal between‐study heterogeneity, and no evidence of publication bias) in the umbrella review [ 4 ].

The analysis yielded several significant findings: Firstly, a highly significant main effect of enrichment was observed on CO 2 consumption efficiency [F(1, 14) = 275.84, p < 0.000001].

The log10-transformed engorged larval weight was a highly significant predictor of the log10-transformed unfed nymphal weight, and the former explained 72.7% of the variation in the latter (Fig. 4 ; regression: F 1, 651 = 1738, p < 0.000001; correlation: r = 0.854, t = 41.859, df = 652, p < 0.000001).

A paired t test revealed a highly significant and strong decrease in the mean slope from the EO to EC condition in the combined group of subjects ( T (82) = 5.81, p < 0.000001, Cohen d = 0.64), as well as in the separate groups (TD: T (44) = 3.67, p = 0.0006, Cohen d = 0.55; ASD >85 : T (22) = 3.38, p = 0.0003, Cohen d = 0.71; ASD <85 : T (14) = 3.31, p = 0.005, Cohen d = 0.85; Fig. 2 D).

7 ) revealed that the increase in accuracy was highly significant (monkey A: χ 2 = 95.3, P < 10 −6 ; monkey G: χ 2 = 60.6, P < 10 −6 , Chi-Square test).

This is statistically highly significant ( P < .000001) in comparison with their mean preoperative score (M0-1/5).

Corresponding studies with 89 Zr-DFO-ZEGFR:2377 resulted in 17.7 ± 0.3% (A431) and 23.8 ± 0.2% (MDA468) cell-associated radioactivity. Pretreatment of A431 and MDA468 cells with EGFR specific antibody cetuximab led to a highly significant (<0.3% of total activity; P < 1 × 10 –6 ) reduction of binding of 89 Zr-labeled affibody bioconjugates indicating highly specific targeting properties ( Figure 3 A).

To find 44 of 46 studies showing a positive risk ratio was very highly significant, P<0.000001.

First, the main effect of stimulus disparity was highly significant (F(2.12, 29.68) = 27.99, p<10 −6 , r = 0.667, S1 Table ) in rANOVA.

MICs of individual and combined EOs were statistically compared using one-way ANOVA ( n = 3), revealing highly significant differences ( p < 0.000001) for all tested fungal species.