Excerpts

Moreover, the regressions are highly significant, as reflected by F = 127.60 and p = 5.15 × 10−7 for cohesion and F = 69.26 and p = 8.32 × 10−6 for the internal friction angle.

Consistently, our data demonstrated a highly significant decrease in the expression of this direct MYC target in tumors treated with FPPa-OmoMYC relative to vehicle ( p = 5.16 × 10 −7 ) (Fig. 3c ).

Similarly, of the 17 genes in the “Chondroitin sulfate metabolic process,” which was highly significant in the ethanol-upregulated genes in the IP fraction ( p = 5.26 × 10 −7 ), and all ethanol-regulated genes ( p = 8.69 × 10 −4 ), 16 were upregulated by ethanol, suggesting that this process was highly upregulated in ethanol-exposed astrocytes.

hypogaea was included in the data matrix, the phi test was highly significant ( P = 5·273E-7; 148 informative sites; mean = 0·254; variance = 4·852E-4; observed = 0·147), reflecting the allotetraploid nature of this species, most probably comprising the A genome from A. duranensis and the B genome from A. ipaënsis.

As a result, we found sex differences at highly significant levels in the pheomelanin mol% ( p = 5.3 × 10 −7 ) and a significant difference in A650/A500 ( p = 0.0058).

The computed probability p(uncorrel) reveals that the correlation is clearly significant because the probability that r is equal to zero is far below 0.05 ( p = 5.31 × 10 −07 ).

The difference in EPS score, biofilm, and Nugent score between included and excluded patients was highly significant ( p = 5.4 × 10 −7 , p = 0.0005, and p = 0.0007; Additional file 4 : Figure S3A).

This effect was highly significant for both deletion and mutation of these sequences within both elements, albeit more severe for Sox10 -MCS7 (≥80% reduction in enhancer activity, p≤5.42×10 −7 ) than for Sox10 -MCS4 (50–80% reduction in activity, p≤2.11×10 −7 ).

ANOVA performed on the specimen-level average pore-size values ( P ̄ i j ) showed that extrusion temperature was the dominant and highly significant factor affecting pore size ( F = 19.9 , p = 5.439 × 10 − 7 ), whereas printing speed was also significant, although to a lesser extent ( F = 4.34 , p = 1.84 × 10 − 2 ).

Additionally, Label 12 showed highly significant results in the AF_L (F-statistic = 12.99599, p = 5.45E-07) and PYT_L (F-statistic = 10.1636, p = 1.48E-07) bundles. 3.3 Experiments on relapsing-remitting MS data Our pipeline was applied to the MS dataset for a set of relevant bundles in the context of MS studies: AF, ILF, IFOF, and PYT.

Additionally, GCM1 showed highly significant enrichment for known autism susceptibility markers ( P = 5.49E-07; Fisher’s exact test) [ 46 ], and the expression levels of genes in this module were significantly higher during early brain development (Additional file 2 : Figure S4C).

However, the association between rs9465922 and IS remained highly significant after adjusting for self-reported diabetes status in our population (OR = 0.55, 95% = 0.44–0.70, P = 5.5 × 10 −7 ), suggesting the effect of this gene on IS may be independent of the effect of T2D.

Even with some inconsistencies between the results of SNP array analyses and those of real-time genomic-PCR analyses, the association between them was highly significant ( P = 5.58E-07 by Fisher’s exact test).

Importantly, the sex differences in leptin and adiponectin ratios remained highly significant after further adjusting for BMI (leptin, P = 5.6 × 10 −7 ; adiponectin, P = 5.7 × 10 −8 ).

As an example, the analysis of 514 kidney clear cell carcinomas (KIRC) with the 23 transcripts comprising the Pyrimidine Biosynthesis Pathway generated two distinct t-SNE clusters containing nearly identical tumor numbers and associated with highly significant median survival differences (2090 days vs. > 4500 days, P = 5.6 × 10 − 7 , Fig. 1 a and b and ref.

The model demonstrated strong risk stratification performance in the training set, with a highly significant difference between high- and low-risk groups ( p = 5.684 × 10 −7 ).

12 Although RBM20 mRNA levels tended to be higher in both DCM and ICM samples compared to controls ( Figure 3 E ), the increase did not reach statistical significance in DCM ( P = 5.73 × 10 −7 ; Log 2 FC = 0.92).

A highly significant genetic correlation was identified between the questionnaire-based hearing loss phenotype in the UK Biobank and phenotype HIGH (rG = 0.751, P = 5.75*10 −7 ).

The combined allelic test was highly significant, with p = 5.9 × e-7.

GWAS identified 10 highly significant SNPs for BC ( P = 5.96 × 10 –7 –1.04 × 10 –9 ) ( Supplemental Table 2 ).

Among 312 GO terms enriched with these genes, 22 were seed GO terms yielding a highly significant enrichment of seed GO terms ( p = 5.97e-7 ).

Insulin response The changes in insulin concentration by time were highly significant (p=6×10 −7 ).

The 52 targets with high cancer cytostatic scores contain 8 out of 24 known targets of the 14 FDA-approved metabolic anticancer drugs found in DrugBank ( Wishart et al, 2008 ) ( Supplementary Tables S1, S2 and S5 ), representing a highly significant enrichment (hypergeometric P -value <6 × 10 −7 ), testifying to predictive power of the model.

This stratification of patients by total poor prognostic events demonstrated highly significant associations with survival in both the Miller (p = 6e-7) and Pawitan (p = 4e-7) cohorts.

One month after the therapy shift (T3), we detected a highly significant decrease in the BRAF p.V600E and MEK1 p.P124L MAFs ( p = 0.0000006 and p = 0.0005, respectively).