Excerpts

Upon adjusting our linear models for these cell fractions, the hypomethylation at cg19803194 remained highly significant (adjusted p-value = 2.14 × 10 − 7 ).

This gene score and anxiety had a highly significant interaction effect on WM ( p = 2.14E−7).

Although they did not survive false discovery rate correction (FDR) for multiple testing (Additional file 1 : Table S3), the nominally significant pairwise comparisons showed enrichment for π c differences related to hematological and metabolic traits (hematological fold-enrichment = 4.45, p = 2.15 × 10 –7 ; metabolic fold-enrichment = 4.05, p = 4.01 × 10 –6 ).

Results For EA, rs13429103 at chromosome 2p25.1, near the RNF144A-LOC339788 gene, showed a borderline significant interaction with smoking status ( P = 2.18×10 -7 ).

was markedly stronger at 37°C ( r = 0.799) than at RT ( r = 0.587), yielding a highly significant Fisher's Z statistic ( Z = −5.18, p = 2.23 × 10 − 7 ) and a back‐transformed 95% confidence interval that excluded zero (−0.53 to −0.26).

In ErbB4-transfected cells, as expected, NRG1 induces a highly significant increment in the number of migrated cells (P = 2.24E-07), while NMDA alone does not significantly alter basal migration (P = 0.986).

Meta-analysis of SNPs common to all four GWAS ( N = 6661818 and N = 6496414 for all AML and cytogenetically normal AML, respectively) also revealed additional borderline significant susceptibility loci at 1p31.1 (rs10789158, CACHD1 , P = 2.25 × 10 −7 ) for all AML and at 7q33 (rs17773014, AKR1B1 , P = 4.09 × 10 −7 ) for cytogenetically normal AML, both with consistent direction and magnitude of effect across all four studies (Figs. 1 and 2 ).

The Kruskal–Wallis test confirmed a highly significant group effect (H = 36.48, p = 2.30 × 10 −7 ), supporting the robustness of the observed intergroup differences.

The effect of motion coherence on the perceived direction separation was highly significant (one-way ANOVA, F(5,18) = 24.3, p = 2.3×10 −7 ).

The recombination rate in females is notably higher near the centromere, whereas in males it is higher near the telomere (a highly significant difference: p = 2.3 × 10 −7 ), similar to the pattern observed in humans.

Another SNP, rs12955302, was close to significance in the SIgAD meta-analysis (p = 2.3e-7) before reaching it in the cFDR analysis. rs12955302 is located in an intron of PTPN2 , an immunologically salient gene, and is associated with a range of IMDs including Crohn's disease, ulcerative colitis [ 121 ], T1D [ 62 ], and coeliac disease [ 152 ].

27 Although the published FSHB promoter polymorphism was not the strongest signal in this region, it was genome-wide significant for association with LH in our data ( P= 4.84 × 10 −9 ), and nearly significant for FSH ( P= 2.31 × 10 −7 ) ( Supplementary Table 11 ).

However, combining the EU, AA, and CH groups revealed a highly significant association of ARC SNP rs35900184 (p = 2.353 x 10 −7 ; OR [95% CI] = 1.54 [1.310–1.820]).

One-way ANOVA confirmed a highly significant effect of drying method on TAC (F(3,8) = 148.6, p = 2.36 × 10 −7 ), and Tukey’s HSD test classified the methods into three distinct groups: freeze drying (a), oven/sun drying (b), and vacuum drying (c).

The overall difference in detection rates for culture and MDx was very highly significant, p -value = 2.384 × 10 −7 .

PLR latency We identified four highly significant differentially methylated probes associated with three PLR latency phenotypes at a stringent p-value threshold ( p < 2.4 × 10 − 7 , see Table 2 ).

The turquoise (#12) module had a highly significant overlap with synaptic proteins in general ( P =2.4e−7), but the blue (#2) module was not enriched in synaptic proteins ( Figure 5B ).

Multiple analysis by the number of all risk genotypes showed a highly significant association with CAP ( P = 2.4×10 -7 , OR = 3.03, 95% CI 1.98 to 4.64) with the threshold for three risk genotypes.

Another almost significant epistatic interaction (P = 2.42E-07) was also identified between these same markers for total branches at harvest.

Although these SNPs were highly significant (p-value < 2.47 × 10 –7 ) with strong effects on CW, due to their low minor allele frequency (0.01 ≤ MAF < 0.023) their contribution to the genetic variance of the trait was relatively small (0.09–1.28%).

Note, however, that in the same time, both haplotype based tests reveal a number of significant SNPs (one highly significant, p = 2.5×10 −7 , in the case of linear regression) among those within the transcript itself and used as informative markers for the detection of AI.

Results There was a highly significant positive correlation between the total number of YGLs in a country and the median (ρ = 0.36, p = 2.5×10 -7 ) and maximum (ρ = 0.34, p = 1.6×10 -6 ) GRSI during the second wave of the pandemic, but not during the first wave.

One gene demonstrated a highly significant association that satisfied the empirical Bonferroni’s correlation ( p =2.5×10 −7 , effect size=−1.19, R6FCZ7).

Differences in rapidity and severity of systemic signs An ANOVA analysis of the differences among the strains with respect to the rapidity of the development of the first signs of systemic disease produced extremely highly significant results: p = 2.5 × 10 -7 .

1c ), the estimate of MAE was almost unchanged and remained highly significant ( β = 0.047, P = 2.56 × 10 –7 ), whereas the estimate of PAE decreased substantially and became nonsignificant ( β = 0.015, P = 0.08).