Excerpts

In particular, we found a highly significant positive correlation between disease and the Magenta (comprised of 576 genes) module eigengene ( r = 0.67, P <2 × 10 -7 ), the Brown (2,502 genes) module eigengene ( r = 0.6, P <6 × 10 -6 ), the Light-Cyan (349 genes) module eigengene ( r = 0.42, P <0.002), and the Grey60 (based on 216 genes) module eigengene ( r = 0.47, P <8 × 10 -4 ).

However for responses evoked by octopamine and dopamine the correlation is high and highly significant (OA: r s = 0.93, p = 2e-7 [n = 24 responses from 6 oocytes]; DA: r s = 0.97, p = 2e-7 [n = 14 responses from 5 oocytes]).

This is highly significant in EUR, when compared to the negative control regions, and modestly significant in ASN (<p = 2x10 -7 and p = 0.01 for EUR and ASN, respectively) and appears inconsistent with the null hypothesis of neutral evolution and demography at the LCT locus especially in the EUR populations.

Mantoux test results were positive in 75.47% of cases and 24.53% of controls, and the difference was statistically highly significant ( P = 0.0000002).

Indeed, 69% of genes analyzed showed negative Z -scores in whole blood relative to other tissue types, which is highly significant ( p < 2 × 10 −7 , assuming a binomial distribution).

There were 55 overlapping genes between these two datasets, a markedly significant enrichment (p < 2e-7).

Total between-groups Q, shown at the bottom of Table 8 (Q = 33.93, df(Q) = 3) indicates that there is a highly significant difference between the effectiveness of the four meditation categories on PTSD ( p < 0.0000002). 3.1.

Lab values of included intervals ), mean baseline HIC and SF were not different (p < 0.7 and p < 0.2 respectively); overall, HIC and SF worsened during deferiprone treatment (p < 0.001 and p < 0.0003, respectively), and improved during deferasirox treatment (p < 0.001 and p < 0.0001, respectively); follow-up HIC values differing between deferiprone and deferasirox monotherapies were highly significant (p < 0.0000002).

Simple linear regression revealed a highly significant relationship ( p < 0.0000002) between road kill samples collected and rabid meso-carnivores detected in 2016 (r 2 = 0.86).

Expectedly, their accumulation in the GRAS males yielded a highly significant Jonckheere–Terpstra trend ( P =0.0000002).

While rs7041 only had a modest statistical association in our single-SNP GWAS ( p =2.8×10 −4 for antenatal and p =0.01 for cord blood), the results for haplotype association ( Table 4 ) were highly significant (ANOVA p =2.0×10 −7 for antenatal and p =3.0×10 −6 for cord blood).

For example, in a large pooled analysis of 14 cohort studies, there was a strong trend with smoking interval before first birth after adjustment for potential confounders that included age at first birth and number of live births ( P = 0.0000002), whereas after stratification by age at first birth, the trends in each stratum were weaker ( P = 0.12, 0.02, and 0.28) [ 8 ], which is suggestive of confounding.

Here we found clear differences between non-smokers (2.12 ± 2.07 μg/g creatinine) and smokers (411.37 ± 351.41 μg/g creatinine) that are highly significant (p = 2 × 10 −7 ).

Analyzing AZGP1 expression as a continuous variable showed a modest, but highly significant inverse correlation between AZGP1 expression and microvessel number ( r = −0.19, p = 2 × 10 −7 , Fig. 7 K).

However, according to the Spearman rank correlation analysis the expression of IGF-IR and VEGFR-2 was highly positively correlated and statistically highly significant (r = 0.745 and p = 0.0000002) ( Figure 7 ).

When considered together, the 19 methylation biomarkers demonstrated exceptional predictive power, with an AUC of 0.95 and an accuracy of 0.88 at a highly significant P = 2.02e-07 ( Fig. 2 A ).

Among the 401 genes implicated in ID, we identified 106 genes coding for GRFs, which represents a highly significant enrichment of GRFs among all ID genes (hypergeometric test, p = 2.03 × 10 −07 ).

For the four higher concentrations, there are highly significant differences among groups (10 −2.5 F 3,76 = 14.145 *** p = 2.05 × 10 −7 ; 10 −2 F 3,76 = 60.371 ***, p = 4.56 × 10 −20 ; 10 −1.5 F 3,76 = 50.504 ***, p = 4.63 × 10 −18 ; 10 − 1 F 3,76 = 26.148 ***, p = 1.01 × 10 −11 ; *** = p < 0.001).

The effect of growth forms was insignificant in the Asteraceae and the Brassicaceae, possibly due to the limited number of non‐herbaceous species, but the effect was highly significant in the Solanaceae where non‐herbaceous species are abundant ( p = 2.078 × 10 −7 ).

Polygenetic risk score (PRS) constructed by using three independent SNPs (rs1410996, rs4698775, and rs2043085) showed highly significant association with CSC ( p = 2.10 × 10 –7 ), with the top 10% of subjects with high PRS showing 6.39 times higher risk than the bottom 10% of subjects with lowest PRS.

While saliva sample volume remained the variable with the largest effect (P = 6.8x10 -27 ), DNA turbidity and purity where highly significant at P = 2.1×10 -7 and P = 1.8×10 -4 , respectively.

The cross-validated model was highly significant for the difference between matched case and control sample (p = 2.1*10 −7 ).

The association between p57 negativity and CHMs was highly significant (χ 2 = 26.94, p = 2.1 × 10 −7 ; Fisher’s exact p < 2 × 10 −7 ).

All CpG sites, except one site (cg21161138) near AHRR , remained nominally significant (3.17 <| z |< 5.19, 1.52e − 03 < p < 2.10e − 07) with the same direction of association in the sensitivity analysis adjusted for smoking (Additional file 1: Table S1 and Fig.

Fisher’s exact test revealed a highly significant ( P = 2.13e−07) association between viruses in the species Magarnavirus gigas (proposed) and oysters with obvious signs of disease, when compared to naturalized beach oysters with no sign of disease.