Excerpts

Within the binding regions of the 25 most significantly up-regulated genes linked to a GW7647-induced PPARα binding region, we identified a highly significant ( p = 6.94 × 10 −8 ) module composed of the TATA binding protein (TBP, O$TBP) in combination with the PPAR binding motif V$PERO ( Figure 5 A).

Oligomers also induced very low level, but highly significant, toxicity to astrocytes ( p = 6.968E − 8), and this was prevented by TLR4 antagonists (RSLA; p = 7.746E-8, TAK242; p = 8.103E − 8, Fig. 6 cii).

Furthermore, we assessed prognostic differences between these two subgroups with a recurrence-risk analysis, and the difference between the two subgroups was extremely significant (log-rank p = 7 × 10 −8 ), with a C-index of 0.684 ( Figure 5 ). 3.2.3.

For instance, the highly significant cotargeting miRNAs miR-124 and miR-9 had strongly correlated expression patterns (R Spearman = 0.82, P = 7 × 10 −8 ).

In agreement with these findings, we observed a highly significant relationship between A3B expression and p53 mutational status in the METABRIC ( P = 7.0 × 10 −8 ) and TCGA ( P = 2.2 × 10 −16 ) breast cancer cohorts (Figure 1A ).

Auditory spectrotemporal receptive fields (STRFs) (Figure 9C,Di ) were only moderately affected in Otogl +/− mutant mice relative to Otogl +/+ controls, with a slightly significant change in response latency ( p = 7.10 −8 , nested two‐way ANOVA, group effect, animal factor nested in group, F(1,1379) = 29.5) and a 5.8% decrease in frequency bandwidth ( p = 0.048, nested ANOVA, F(1,1379) = 3.9), with no change in maximum evoked firing rate ( p = 0.06, nested ANOVA, F(1,1379) = 3.5).

The identified lead SNP rs3732593 was extremely significant (P = 7.19 × 10 −8 ) in the discovery FHS sample but was only nominally significant (P = 0.04) in the replication sample.

Results Among pediatric subjects with WGS data, we identified a significant intronic variant in EDIL3 (rs149378, P = 1.9 × 10 −8 ) and a nearly significant intronic variant in LHX4 (rs79008224, P = 7.2 × 10 −8 ).

While this failed to surpass Bonferroni correction, the p -value across stages was highly significant (rs823128, p =7.3×10 −8 ) and it is worth noting that the significance improved for all SNPs at this locus when combining stage I and II results ( Figure 2C ).

3c ) and a less strong yet still highly significant directional effect of intelligence on BV ( b xy = 0.139, SE = 0.026, P = 7.34 × 10 −8 ; Fig. 3d ), suggesting a bidirectional association between these phenotypes, in line with the previous reports 53 .

Highly significant enrichment was uniquely found within the first quartile of ranked genes, including metabolic ( P < 7.4 × 10 -8 ), post-translational modification ( P < 9.7 × 10 -5 ) and developmental ( P < 1.3 × 10 -6 ) processes (all Benjamini-Hochberg adjusted).

Although no other SNPs reached genome-wide significance in the conditional analysis, a few borderline significant signals emerged: rs191288953 ( p =7.41E-08; chromosome 7; closest gene SDK1 ) and rs79935880 ( p =7.69E-08; chromosome 10; near MTRNR2L7 ) for C22:0 ceramide levels and rs34432959 ( p =8.68E-08) and rs12963655 ( p =8.00E-08) for C24:0 ceramide levels, both of which are located near SYT4 on chromosome 18.

In the secondary, combined meta-analysis, a total of 57 SNPs were associated with BDR at p<5×10 −6 ( supplementary table S2 ), 21 SNPs after linkage disequilibrium clumping ( table 2 ) and one SNP (rs4782614) associated with BDR as defined by per cent change in FEV 1 nearing significance (p=7.5×10 −8 ).

A third highly significant SNP ( p < 7.60 × 10 −8 ) was located on chromosome B04 (AX-147248780) at positions around 130738535 with 20 candidate genes within proximity, including several disease resistance proteins (TIR-NBS-LRR) ( Arahy.RGV79Z , Arahy.27BWBV , Arahy.QZS0X1 , Arahy.IB6E9K , Arahy.IB6E9K , Arahy.27QVSF , Arahy.EG26MQ , Arahy.

The clusters are highly significant in predicting survival (likelihood ratio = 37.0; p = 7.6×10 −8 ), also accounting for clinical and histopathological information (age, stage and cancer type; Methods), showing that considering the mutation data and their interactions provides a more complete and informative picture of tumours and their progression.

We observed a highly significant association of SNP rs7301743 in TBX3|MED13L with a 0.071 mV (95% CI, 0.038–0.11 mV) smaller voltage of the R wave in V5 per minor allele copy (P = 7.635 X 10 −8 ).

Meta-analysis of two independent Japanese datasets demonstrated a marginally significant association of SNP rs7301743 in TBX3|MED13L with a 0.071 mV (95% CI, 0.038–0.11 mV) shorter R wave amplitude in the V5 lead per minor allele copy (P = 7.635 x 10 −8 ).

Mega‐analysis of the effects of each APOE genotype compared with the ε3ε3 genotype showed highly significant associations for the ε3ε4 ( β = −1.41, p = 7.68 × 10 −8 ) and ε4ε4 ( β = −2.41, p = 3.32 × 10 −3 ) genotypes and suggestive‐effect significance for the ε2ε3 genotype ( β = 0.55, p = 8.26 × 10 −2 ) (Table 1 , Model 1). 2.3 Independent associations of TOMM40 and APOE polymorphisms with BMI Despite moderate LD between rs2075650 and rs429358 (Figure 1 ), bivariate mega‐analysis with these SNPs identified their independent associations with BMI, although their effects became smaller (Table 1 , Model 2).

Other components display moderate to weak correlations (0.40 > r > 0.11), even though most are highly significant (8.4*10 −87 < p < 7.7*10 −8 ) (Table S3 ). 3.4.

The reduction of 6.6 ± 0.8% is highly significant ( p = 7.7E-08).

Most notable is the association between sEPSC amplitude and WCST in the combined SCZ+CON sample, with a highly significant main effect across groups ( P = 7.75E-08, adjusted R 2 = 0.8947) and interaction of sEPSC amplitude with diagnostic group ( P = 1.23E-08).

The SNP rs9632837 was near significance in our SIgAD meta-analysis (p = 7.9e-8) and became significant in the cFDR analysis.

2008 ) to calculate expression plasticity and found that overall correlation between noise and plasticity is weak but highly significant (rho = 0.14; P = 8E−8).

An additional locus was borderline significant ( P = 8×10 −8 ), but was externally validated.

In addition, a large 1.4 Mb region at chromosome 17q21.31, coextensive with a known inversion polymorphism, 42 harbored 101 nearly significant SNPs (all P 's<10 −6 ; top SNP, rs916888, P =8.18 × 10 −8 ).