Excerpts

Separate analysis of the deletions and duplications showed a highly significant effect from the deletions ( β = 2.56 cm, P = 8.2 × 10 −8 ).

There were highly significant differences in the levels of Ty mobility among strains encoding heterospecific NUP84 (one-way ANOVA, p = 8.2 x 10 −8 ), and levels of Ty1 mobility were significantly different in strains containing NUP84 S . mik , NUP84 S . kud , and NUP84 S . bay when compared to NUP84 S . cer (Tukey–Kramer method, p<0.05) ( Fig 5A ).

DOX-OCA (2 μM DOX encapsulated in 5 μg PLGA, 48 h) also induced highly significant cell death of OCI-Ly19 ( p = 8.4 × 10 −8 , n = 5 replicates) ( Figure 4 , Figure S3 shows a representative dot plot illustrating the cell death gating strategy).

This revealed a highly significant 1.5 fold increased AD risk in children of FLG -carrier mothers (S1 meta-analysis = 1.50; P = 8.4 x 10 −8 ; Table 3 ).

Furthermore, 817 genes remained highly significant after stringent Bonferroni correction ( P < 8.5 × 10 −8 ; FDR = 0.0001).

At an FDR threshold of 0.01, all of the solutions were highly significant ( p = 8.5×10 −8 for NGT-EMRN, 7.4×10 −9 for NGT-CMRN, p = 7.0×10 −15 for IGT-EMRN, p = 0.025 for IGT-CMRN, respectively, Mann-Whitney-Wilcoxon test) indicating that the clustering of metabolite changes in the network is highly non-random.

CD, MOSGWA selected 14 SNPs, including rs17659990 (P=5.43×10 -9 , DOCK3 ) that reached the generally accepted level of genome-wide significance, followed by borderline significant rs7742915 (P=8.52×10 -8 , BTBD9 ), rs16944613 (P=1.49×10 -7 , CRTC3 ), rs13129679 (P=2.38×10 -7 , RNF4 ) and rs12953717 (P=3.00×10 -7 , SMAD7 ), a well-known CRC susceptibility variant.

Genome-wide association studies (GWAS) of 55,977 single-nucleotide polymorphisms identified in one or more strains found one highly significant association ( P = 8.78E-08) between a nonsynonymous mutation at codon 481 (H481) of the rpoB gene and increased vancomycin MIC.

However, a signal of three SNVs in tight linkage-disequilibrium (LD) in an intron of the Sterile Alpha Motif Domain Containing 3 ( SAMD3) gene (chromosome 6) achieved near statistical significance in the CO-MED cohort, with the tag SNV (rs870816) reaching p = 8.8 × 10 −8 ( t = −4.49).

Two imputed SNPs (rs115231074: p = 1.3 x 10 −10 and rs35079132: p = 3.8 x 10 −8 ) achieved genome-wide significance, and one adjacent genotyped SNP was nearly significant genome-wide (rs4321864: p = 8.8 x 10 −8 ).

Traits with higher heritabilities yielded proportionally more QTLs: the mean heritability of those traits for which at least one QTL was identified was 30.6%, compared to 20.6% for those without QTLs, a highly significant difference (t-test P-value = 8.9x10 -8 ).

However, the difference between the numbers of uniquely mapped reads to each genome was highly significant ( p = 8.95E-08).

For example, there were significant associations between PTVs in PSAP and increased progranulin ( GRN ; P = 5.5 × 10 −17 ; β = 2.60; 95% CI, 1.99 to 3.21) and cathepsin B ( P = 1.2 × 10 −11 ; β = 2.10; 95% CI, 1.49 to 2.70), and a nearly significant association with increased cathepsin D ( P = 9.0 × 10 −8 ; β = 1.61; 95% CI, 1.02 to 2.20) (Supplementary Table 8 ).

In particular, rs7402241 T displayed a highly significant association with worse baseline cognition, approaching genome-wide significance (estimated effect = −0.37, 95% CI −0.51 to −0.24, p = 9.0 × 10 −8 ).

We investigated the cause of the female obesity phenotype and noted a highly significant fat mass increase (P = 9E-08; S4D Fig ), alongside a blood cholesterol increase (P = 4E-05) and high-density lipoprotein levels (P = 0.003) ( S4E Fig ).

Although subjects differed in their use of the full scale of possible bid values ( Figure 2A ), their preference data was well-described by a logistic regression: a one-sample t-test on the sensitivity of like responses on bid value was highly significant (t(16) = 9.2, p = 9×10 −8 ).

Welch’s t -test indicated a highly significant difference in centroid size between sexes (t = −7.14, df = 27.95, p = 9.1 × 10 −8 ), with the 95% confidence interval for the mean difference (female–male) ranging from −11.03 to −6.11.

In addition, they were all highly significant: 4.8448 × 10 −302 < p < 9.1062 × 10 −8 .

In the horse, BIEC2–310909 (rs69041973) was highly significant ( p = 9.27 × 10 -8 ) as shown in Figure 5 .

3.1 Apoptosis in CD8 + T lymphocytes correlates with systemic iron levels In general, a highly significant difference was found between the CD4 + and CD8 + T-lymphocyte subpopulations in terms of the percentages of apoptotic cells (T Test p = 9.4x10 -8 , KS-Test p = 0.000002), with the average apoptosis percentage being 21.8% ±9.9% in CD4 + T cells, and 47.3% ±21.8% in CD8 + T cells.

However, a highly significant difference ( P = 9.4 × 10 -8 ) was observed between the K S distribution of ortholog pairs containing human disease genes, and the K S distribution of pairs not containing disease genes (Figure 1b ).

There was also a strong and highly significant correlation between the D -statistic estimates from the two references (Pearson’s product moment correlation test: P = 9.4 × 10 − 8 , R = 0.895).

Consistently, we found nominally significant associations with risks of both, myeloid (log(OR) = 1.52, P = 9.5 × 10 −8 ) and lymphoid (log(OR) = 1.38, P = 3.1 × 10 −7 ) leukaemia, but also multiple myeloma (log(OR) = 1.07, P = 5.1 × 10 −5 ) and non-Hodgkin lymphoma (log(OR) = 0.81, P = 4.7 × 10 −4 ).

In fact, the comparison of Low (L) vs High (H) and Medium (M) vs H serum levels of Ig shows highly significant different allelic frequencies (constantly p < 9.9E-08), only in the population of children.

flexneri was very highly significant ( P < 0.0000001), but survival of alone-cultivated A. castellanii compared to that of cocultivated with plasmid-cured S. flexneri was not statistically significant ( P = 0.88).