Overall, the hypothesis that the number of fibre mats affects the mixing index was highly significant (p = 5.15 × 10 −8 ).
Excerpts
Pearson's linear correlation 0.804 was also highly significant (P < 5.15 × 10 −8 ).
Of particular importance, a model containing independently associated markers, BMI, age and smoking status, although highly significant ( p =5.186e-08) was only able to explain 5.2% of the overall variation in PCSK9 plasma levels in our sample, genetic information being the variable with the highest effect size in our model.
We run a GWAS Cox model, with the first 10 PCs, age, age 2 , sex, period of infection and patient series as covariates and we found one variant (rs117011822) associated with survival at P -value < 5.0 × 10 −8 (genome-wide significance level) and another one (rs7208524) nearly significant ( P -value = 5.19 × 10 −8 ).
Statistical analysis using a paired t-test confirmed that this improvement was highly significant ( p = 5.2 × 10−8), indicating a robust educational impact.
In the current study, a highly significant association was observed between the frequency of IL4 −590 SNP in 98 individuals allergic to D. pteronyssinus and 116 controls and the T/C genotype (p = 0.000000052) and the C allele (p = 0.010), suggesting a protective effect against sensitization to dust mites.
Notably, miR‐142‐3p expression is one of the miRNAs that is significantly increased by chronological age in peripheral blood [ 8 ] and an MIR142 ‐proximal genetic polymorphism (rs2632516) was borderline significant for late‐onset Alzheimer's disease in a genome‐wide association meta‐analysis ( p = 5.3 × 10 −8 ; genome‐wide significance at 5 × 10 −8 ) [ 9 ].
near statistical significanceP = 5.4 × 10 −8
There was one locus with two SNPs in proximity to each other, rs76008716 and rs57957360, which were near statistical significance ( P = 5.4 × 10 −8 ) and had not appeared in the top loci of other analyses.
rs6483495, an intronic variant of MAML2 located at 11q21, showed the borderline significant p -value (Beta = −0.14, P = 5.4 × 10 −8 ) (Fig. 2b and Table 2 ).
Indeed, the difference in k is highly significant ( p = 5.41 × 10 −8 ).
approached significancep = 5.45 × 10 −8
Similarly, a multivariate association test focused on the three RAN traits revealed a genome-wide significant association of rs17663182 ( p = 1.15 × 10 −8 ), while rs16928927 association only approached significance ( p = 5.45 × 10 −8 ).
There was a highly significant difference in GJA9 allele frequencies between PN cases and controls from the original GWAS cohort ( p < 5.5 × 10 −8 ), reflected in a difference in genotype frequencies under a dominant model ( p < 1.2 × 10 −7 ), but not a recessive model ( p < 0.05) (Table 1 ).
Our strategy reveals an overall highly significant association of rs693 with MI (p=5.5×10-8) that is contrasted with a weak estimate following the traditional, sample-size-centered GWAS strategy (p=0.16) in the same sample.
a trend toward significanceP = 5.5 × 10 −8
However, two variants on chromosome 17 showed a trend toward significance in the Sierra Leone cohort (Table 1 and Extended Data Fig. 2e ). rs73397758 ( P = 5.5 × 10 −8 , odds ratio (OR) = 9.16) is ~350 KB (kilobase pairs) downstream of the gene CASC17 , a long non-coding RNA named for a genetic association with prostate cancer 37 , and 570 KB upstream of KCNJ2 , a potassium inwardly rectifying channel 38 . rs143130878 ( P = 1.1 × 10 −7 , OR = 6.87) resides 62,472 base pairs downstream of the gene CCT6B 39 , which is a member of the molecular chaperone (TRiC) family that has been shown to regulate the replication of arenaviruses, including LASV 40 .
showed a trendP = 5.5 × 10 −8
However, two variants on chromosome 17 showed a trend toward significance in the Sierra Leone cohort (Table 1 and Extended Data Fig. 2e ). rs73397758 ( P = 5.5 × 10 −8 , odds ratio (OR) = 9.16) is ~350 KB (kilobase pairs) downstream of the gene CASC17 , a long non-coding RNA named for a genetic association with prostate cancer 37 , and 570 KB upstream
However, this association is provisionally retained because the MR-PRESSO global test for pleiotropy was highly significant ( P = 5.50 × 10 −8 ), and the outlier-corrected estimate remained significant and directionally consistent with the primary IVW analysis (OR 0.41, 95% CI: 0.31–0.54).
The OMG difference for KCNJ16 , decreased in glioblastomas, became highly significant, p = 5.532 × 10 −8 , and trends for other genes improved.
This difference is highly significant (one-tailed binomial p = 5.59 × 10 −8 ) and agrees well with previous interpretations [ 64 ], demonstrating that rates of chromosomal evolution can vary by over an order of magnitude even among closely related species.
An additional ANOVA examining flavor–sensory correlations revealed a highly significant association for strain Khorisa/NA/3 (H-statistic = 29.56, p = 5.60 × 10− 8 ), indicating that the production of volatile compounds such as cyclohexane, heptane, and oxalic acid substantially contributed to the improved sensory attributes.
In addition, a region on chromosome 17 showed a marginally significant signal led by a marker on the GOSR2 gene (chr17:44967530–45244074, lead variant: chr17:45013271_T_C; minor allele frequency, 15%; β=7.83; SE=1.44; P =5.6×10 −8 ).
The difference on the aggregated confusion matrix of all models of these three pathogens was highly significant ( p -value = 5.6 × 10 −8 , McNemar’s test).
A highly significant non-synonymous SNP was found at position 15,656,689 ( p -value = 5.61 × 10 –8 ) in an ankyrin repeat protein (Medtr2g438720), and the surrounding region contained multiple ankyrin repeat genes within 1 kb of many top SNPs ( Figure 4A and Table 2 ).
approached significancep = 5.64 × 10 −8
Two nearby SNPs, in linkage disequilibrium with rs9966620, also approached significance (rs7243626, p = 5.64 × 10 −8 , and rs7240470, p = 8.05 × 10 −7 ).
5 , 17 As expected based on published literature, 18 controls had a higher number of species than cases, although saliva species failed to reach statistical significance (151 and 38 species identified in plasma, Chi square X 2 = 29.473, p = 5.671e-08; 145 and 64 species found in serum, Chi square X 2 = 15.338, p = 8.988e-05; 90 and 44 species found in saliva, Chi square X 2 = 1.6647e-27, p = 1).
9 A previous study also reported a borderline significant association of the variant rs429358, representing the APOE ε4 locus with PD-AAO ( p = 5.69 × 10 −8 ) in a combined dataset (n = 28,568) comprising IPDGC and 23andMe datasets. 7 The study, however, suggested that the association at the locus could be an age-related effect, with a highly significant association with the age of controls ( p = 1.49 × 10 −5 ).