Excerpts

Together these show that four of the genes investigated ( HLA-C, IL12B, TNIP1 and IL23A ) show highly significant differences in expression levels between involved and uninvolved skin (all with p < 10 −9 ).

However, TR ratings and investments were highly correlated in both conditions (mean linear correlation coefficient r = 0.65 in EC and 0.61 in CC, corresponding to P -values smaller than 10 −8 in both cases) and correlations were also highly significant between TR ratings and ERs (mean r = 0.72 in EC, 0.69 in CC, P < 10 −9 ).

Genotyping of 419 psoriasis families further revealed that CCHCR1*WWCC (four SNPs, 2 each in exons 4 and 10) and HLA-Cw*6 allele were associated with psoriasis [4]. A genome scan of the 220-kb region (at chromosome 6p21) across 171 family-based trios of European origin, identified 59 SNPs (18 in coding and 41 in non-coding regions), of which two SNPs (n.7 and n.9 lying 7 and 4 kb proximal to HLA-C, respectively) were found to exhibit highly significant association (p < 10-9 ), sug- gesting these two SNPs as markers for psoriasis sus- ceptibility [37].

One such QTL, lsq4 on chromosome IV, appeared in three different inter-strain crosses as highly significant linkage-mapping peaks for longevity (each P < 10 −9 ) (Ebert et al., 1993 , 1996 ; Ayyadevara et al., 2001 , 2003 ; Shmookler Reis et al., 2007 ).

3 , Table 1; supplementary material Table S2 ). The gene ontology analysis of the recent human dataset ( Tsankov et al., 2015 ) included few highly significant terms ( P -value <1×10 −9 ) ( supplementary material Table S2 ).

Genome-wide, SLC39A8 (p<4.3×10 −10 ) was one of only 19 genes that passed a combined highly significant statistical association (p<10 −9 ) with tumor aggressiveness [73] .

The top SNP rs2290400 is a highly significant eQTL ( P values < 10 −9 ) for two genes, GSDMB and ORMDL3 , in whole blood (as found on gTEX, Fig. 4 ).

While the alpha-tocopherol had no effects in delaying disability, the selegiline arm show a highly significant effect in delaying the need for L-DOPA treatment over controls (P > 10 –9 ).

It was found that the proportion of the depressed elderly population in India (18.2%) was significantly higher than the rest of the world (5.4%) and this difference was found to be statistically highly significant (x 2 =770.4 and P =.000000001).

It was found that the proportion of depressed elderly population in India (18.2%) was significantly higher than the rest of the world (5.4%) and this difference was found to be statistically highly significant (χ 2 = 770.4 and P = 0.000000001*).

Knowing that multigenic cRM represent 10% of all cRM (967/9720), 25/76 (i.e., 33%) corresponds to a highly significant three-fold enrichment ( p < 10 −9 ).

However, when 1000 WBC were analysed, blasts were detected in 33/37 (89%) of MDS samples compared with 6/30 (20%) of age‐matched controls, a highly significant difference ( p < 10 −9 ).

The Kruskal–Wallis test confirmed highly significant global heterogeneity (H = 94.31, p < 10 −9 ).

6B , the predictions were highly significant at the whole-cortex level ( r =.64, p <10 −9 ).

The latency of this response was faster for faces presented in the proximal than in distant condition (1467 ± 66 and 1690 ± 59 ms respectively) and this difference was highly significant (F = 52.0, p < 10 –9 , Fig. 2 C).

By another GEE, we observed the expected highly significant relation ( p < 10 −9 ) between the histology‐based and MRI‐based measurement of cortical thickness (see Fig 5 ).

Per-dataset replication: The PCI-convergence association replicated across both datasets ( Table 2 ), with correlations ranging from r = 0.497 to r = 0.628, all highly significant ( p < 10 −9 ). φ-specificity parameter sweep: The correlation between generalized PCI and convergence peaked near the golden ratio.

Furthermore, while V600E BRAF mutations (over 10,000 described) occur in a mutually exclusive manner with RAS mutations, four of the 34 kinase-dead mutants are coincident with RAS mutations, a highly significant enrichment (p < 10 −9 ; Fisher's Exact Test) that suggests functional interaction.

The transcriptional changes in CE mice were statistically highly significant (ranging from p < 10 -9 to 10 -5 ), and involved ECM processes related to collagen synthesis/modification/assembly and intracellular signaling via the PIP2/PLCg/DAG/IP3 pathway.

We found a highly significant non-random association of non-silent TP53 mutation to HPV negativity (Fisher’s exact test Odds Ratio = 0.14, p < 10 −9 ), suggesting an underlying association, and this was not included in the multivariate analysis.

Differences between the study and control groups in our empirically developed type 3c diabetes index were highly significant (full P value < 0.000000001; Table 2 ).

There is one extremely significant correlation (adjusted p value < 10 −9 ) between class size and year level.

Among all the modules, the turquoise module showed a highly significant association with fibrosis and inflammation levels ( P = 1 × 10 −09 for fibrosis stages and P = 1 × 10 −10 for inflammation grades).

In particular, SII, SIRI, and dNLR exhibited highly significant differences between the control and both infarction groups (p<1E−9), suggesting their potential role as inflammatory and prognostic biomarkers for AMI severity.

An analysis of overrepresented GOs amongst the DEGs (5-fold difference) showed a highly significant enrichment of GO terms ( p < 10E−10), such as ‘neuron migration’, ‘collagen fibril organization’ and ‘anterior/posterior pattern specification’.