Excerpts

If we regress the alt-allele frequency in reads from heterozygotes (y-axis of Fig 3B ) onto the estimates for both a and d simultaneously, both are highly significant as positive predictors of allele frequency (p < 10 −9 for each coefficient).

Knowing that multigenic cRM represent 10% of all cRM (967/9720), 25/76 (i.e., 33%) corresponds to a highly significant three-fold enrichment ( p < 10 −9 ).

Third, there was a highly significant three-way interaction between ranked resistance, environmental structure, and time ( P < 10 −9 ), capturing the decrease in filamentation on solid medium over time, which occurred only for low-resistance types ( Fig. 5B ).

The five most highly significant (FDR P = 1 × 10 −9 ) Gene Ontology (GO) terms for biological process relate to immune system activation and regulation (Supplementary Data 12 ).

De novo MEME analysis (Figure S2A ) reveals that Round 25 aptamers overwhelmingly share a single, contiguous motif that extends across nearly the entire 40‐nt core, with RTAR and its closest relatives showing highly significant full‐length matches ( p < 10 −9 ), whereas the less enriched clusters display only truncated or offset hits to secondary motifs.

The higher the percentages of explanation of variation the better the variables in the models explain the redox parameters. The linear regression model for TAOS accounted for 24.9% of the variation. According to our analyses, highly significant predictors for TAOS were creatinine ( p = 1.04e-09), TG ( p = 1.05e-06), and PH ( p = 0.0006).

We then compared this pulmonary endothelial cell PAH network with the previously described human PAH disease module inclusive of 357 genes ( 19 , 23 , 24 ) and found a highly significant overlap between these 2 networks ( P < 1.04 × 10 –9 ) ( Supplemental Figure 3D ) as well as between the pulmonary endothelial in inflammatory PAH with other inflammatory (positive control) diseases in the human interactome ( Supplemental Table 2 ).

This overlap was highly significant ( P = 1.05 × 10 −9 , hypergeometric test), suggesting QKI directly regulates APA of this subset of mRNAs ( Figures 2A and 1B ).

1 ; interestingly, we found that this enrichment for low-specificity sgRNAs was less pronounced but remained highly significant ( p = 1.1e−9, Fisher’s exact test), showing that the signature of off-target effects can be disguised in noisy screens.

Block H1.2 was highly significant in Stage 2 data ( p = 1.12 × 10 –9 ), while both blocks H1.1 and H1.3 were nominally significant ( p < 0.002 and p < 0.0003, respectively).

The OPLS‐DA identified one highly significant model (CV‐ANOVA p = 1.13177e−09) separating the groups (Figure 1A ).

3 c pattern, the separations between data-point distributions for all nearest-neighbor pairs of pre -transition States are highly significant in one or both of the ΔHbO 2 Sat ( p = 1.2 × 10 −9 –9.3 × 10 −4 ) or ΔtotalHb ( p = 5.5 × 10 −5 –4.3 × 10 −4 ) dimensions.

6 ) and this was highly significant for the proapoptotic targets BAX an d PUMA ( p = 1.2 × 10 −9 and p = 1.8 × 10 −14 , respectively).

Both of these metabolites were correlated with previous targeted measured blood triglycerides showing a highly significant association (r = 0.511; p = 1.2E-9) and (r = 0.348; p = 6.8E-5), respectively.

Moreover, surgical intervention occurred earlier in patients without osteolysis compared to patients with osteolysis (median 11.5 months compared to 72 months when duration since the primary prosthetic joint replacement was considered, and 2.5 versus 36 months since the last surgical intervention; the differences are highly significant with p = 1.2 × 10 −9 and p = 1.6 × 10 −13 , respectively).

The high frequency of the correlation of the known causative gene with the overall LGMD2 gene set is highly significant relative to the mean number of genes (n = 72) in each 6 Mb interval (p-value = 1.24e-09).

A highly significant correlation was found between the spontaneous tumor incidence and urethane-induced tumor multiplicity phenotypes (r = 0.94, −log P = 8.9), whereas correlation between the spontaneous tumor incidence and urethane-induced tumor incidence phenotypes was weaker (r = 0.76, −log P = 3.8) ( Figure 1 ).

This means we found a 7.5-fold under-representation of CTCF sites in the differentially methylated loci (0.2% in differentially methylated fragments vs 1.5% in all fragments), which was highly significant ( p < 1.3e-09 by Proportional Test).

A model combining these three variants was highly significant ( P =1.3 × 10 −9 ) with a 0.85 effect size between lowest and highest risk groups.

Geographic source was determined to be a nonsignificant factor for the expression level of the biomarkers ( p = 0.11), whereas arsenic exposure was determined to be a highly significant factor ( p = 1.3 × 10 −9 ).

The ancestry-enrichment test detected highly significant signals ( P = 1.3 × 10 −9 ) mapping MAK16 , a gene with important roles in ribosome biogenesis during the G1 phase of the cell cycle.

This analysis revealed a highly significant Treatment × Block interaction (F(5,352) = 10.729, p = 1.30 × 10 − 9), indicating that freezing dynamics across experimental blocks differed as a function of treatment condition.

When analysed within the largest of our cohorts (YFS) the minor allelic effect size of rs113288603 increased from non-significant ( beta = 0.05, p = 0.522) to highly significant ( beta = -0.47, p = 1.32E-09) when rs56113850 was added to the model; when an interaction term (rs56113850*rs113288603) was also added to the model the effect size further increased ( beta = -0.62, p = 1.32E-03).

There was a highly significant difference in the percentage of cells classed as place cells by the different methods (p = 1.35x10 -9 , linear mixed-effects model with method as a fixed-effect and mouse ID, with session number nested, as a random effect), with the Information method detecting the highest number (47.0 +/- 12.2% (mean +/- std)), followed by the Peak method (34.5 +/- 11.1%) and the Stability method (16.5+/- 8.8%), while the Combination method only classified 3.9 +/- 1.9% of cells as place cells.

Pairwise group comparisons using Fisher’s exact test revealed a highly significant difference in the morphology of EVs between patients with GBA1-PD carrying the p.L444P and p.N370S mutations ( p = 1.37 × 10 −9 ).