Excerpts

Both correlations were extremely significant (p<10 −10 ).

1 B, were 0.45 ± 0.13 (standard deviation) and 0.92 ± 0.07, respectively; the difference was highly significant (P < 10 −10 , t test for paired measurements).

All quantiles yielded highly significant P -values ( P < 10 −10 ), confirming that the inclusion of the frame force significantly improves model performance.

Interestingly, we found that the rescue of the 259 upregulated genes was extremely significant ( P <<10 −10 ), while the rescue of the 85 downregulated genes was borderline with a chance event ( P =0.052).

As most tested associations were highly significant ( p < 10 − 10 ), precise p-values are reported only for those with p > 10 − 10 .

We find a highly significant improvement in model performance (R 2 of 0.035 vs. 0.14, p < 10 −10 ). 3.2.

We found 1060 upregulated genes in Wit49 and 396 in 17.94, with a highly significant overlap of 212 genes between the two cell-lines ( p < 10 −10 ) ( Figure 3 A).

Finally, we also fitted a linear model that included the interaction between the mother and father genotypes with temperature and found that this interaction was highly significant (LRT: χ 2 = 303.9, df = 8, P < 1 × 10 −10 ).

5C ), and this difference was highly significant within an animal across within-sequence repetitions (Fig. 5D , p < 10 −10 , Wilcoxon Rank Sum test, n 1 = 162, n 2 = 1428) and across animals (Fig. 5E , p = 0.0079, Wilcoxon Rank Sum test, n = 5), as well as in single cells recorded in the ORR in 2p in the same animals (Fig. 5F , p < 10 −100 , Wilcoxon Rank Sum test, n = 765).

These associations were highly significant ( p < 1 × 10 −10 , q < 1 × 10 −10 ).

The difference in the number of apoptotic cells between active and inactive testes of this species was highly significant (active: 5.2 ± 10.7 cells/0.5 mm 2 ; inactive: 169.9 ± 38.4 cells/0.5 mm 2 ; Wilcox test, p = 1.03 × 10 −10 ; Figure 5 E).

Nevertheless, a highly significant, positive correlation, was found between the qPCR and RNA-seq analyses (r = 0.91, P = 1.07 × 10 −10 ; Fig. 5e ), which supported an overall concordance between the results of the two techniques despite the low replicate number for RNA-seq analysis.

For PLINK, a single SNP was deemed marginally significant if it belonged to a epistatic pair with a p-value below the genome-wide threshold P = 1.09 × 10 −10 (i.e.

Results Case-control comparisons showed highly significant mean group differences for accuracy ( p = 1.1 × 10 − 10 ), with an effect size (Cohen’s d = 1.6), more than twice as large as the mean effect size reported in a previous meta-analysis (Uljarevic and Hamilton, 2012, J Autism Dev Disord ).

Consistent with these observations, gene signature–based deconvolution of cell types by xCell ( 24 ) showed highly significant enrichment of immature dendritic cell (iDC) signatures in the normal nasopharynx compared with epithelium from other upper airway sites including the tonsil ( P = 1.11 × 10 −10 ; fig.

Although heterogeneity of response was observed in different cells, the finding that 10 significant cells out of 18 at p < 0.05 was highly significant at the population level (binomial test; p = 1.12E−10; n = 18 recordings from 7 animals).

Analysis of a deposited EWS dataset generated by Savola and co‐workers 48 using the SurvExpress tool 49 showed highly significant separation (hazard ratio 8.99; P = 1.128 × 10 −10 ) of the overall survival of EWS patients into low‐ and high‐risk groups based on the expression of PHGDH , PSPH , PSAT1 , SHMT2 , SLC1A5 , MTHFD2 , and MTHFD1L (Figure 7 G).

The difference between Shift 2 and Shift 3 was also highly significant (mean difference = 4.67, p = 1.13e-10) (Table 5 ).

Furthermore, highly significant enrichments in biological functions have been observed to be related to the immune system; for example, Inflammatory Response (p<1.15E10 −16 –2.06E10 −4 ), Immunological Disease (p<1.11E10 −11 –1.98E10 −4 ), Hematopoiesis (p<7.52E10 −28 –2.91E10 −4 ) and Cell-mediated Immune Response (p<5.87E10 −27 –2.62E10 −4 ) were frequently encountered.

The main effect for the participant group was highly significant (F(1, 332.00) = 44.29 and P = 1.17 × 10 −10 ).

17 Although the computed P -value from this ES is highly significant ( P = 1.18 × 10 −10 ), such a mean increase in blood pressure may not always have clinical implications.

Both main effects were highly significant: experiment type, F (4, 7079) = 13.13, p = 1.18 × 10 −10 , η 2 = 0.0067, and erosion method, F (5, 7079) = 95.04, p = 3.37 × 10 −97 , η 2 = 0.0603.

Some 90 independent replications of these experiments have provided evidence for a highly significant effect (overall effect size = 0.09, z = 6.4, p = 1.2 × 10 –10 ; Bem et al., 2015 ).

The overlap between DEGs and differential TADs was highly significant ( p = 1.22 × 10 −10 , odds ratio = 3.59), indicating a strong enrichment of DEGs within differential TADs.

Recently, a genome-wide association scan with a subsequent replication study involving over 67,000 individuals (7,473 cases and 42,938 controls) of European ancestry produced highly significant evidence of the strong association of a single nucleotide polymorphism (SNP) rs11177 (C/T) with severe hip and knee OA ( P value = 1.25 × 10 −10 ), a missense polymorphism within the nucleostemin-encoding gene GNL3 19 .