Excerpts

Analysis of variance (ANOVA; marginal test with Satterthwaite degrees of freedom, Type III test of fixed effects) shows that there is a highly significant main effect of size (large/small) on duration thresholds ( F 1, 37 = 102.54, p = 3.25 × 10 −12 ).

A third event extended across positions 2661 and 2717, where TYLCV ( KJ830842 ) served as the major parent and an unidentified TYLCV isolate ( ON756218 ) as the minor parent, supported by a highly significant probability ( p = 3.30 × 10 −12 ).

For IgG, t-tests indicated highly significant elevations in case samples of ABPA ( p = 3.36 × 10−12), and SAAS ( p = 4.80 × 10−9); and control samples of HDM ( p = 2.81 × 10−14), and FA ( p = 0.001), with non-significant changes in RTI ( p = 0.193) and UTI ( p = 0.242).

This difference in prevalence was highly significant ( z = −6.949, SE = 2.807, p = 3.67 × 10 −12 ), with fin tissue being less effective in detecting Ranavirus .

A total of 53% of all mCpol systems are encoded in genomes also coding for systems centred on SMODS-domain enzymes (cGAS/DncV-like nucleotidyltransferases (CD-NTases)), a highly significant linkage ( P = 3.7 × 10 −12 ) indicative of functional coupling between them (Fig. 5b and Extended Data Fig. 9b,c ).

These differences were highly significant for both comparisons (two-sided Wilcoxon rank sum tests, P = 3.716 × 10 −12 , n = 21, Figure 1B ).

Statistical analysis using the Fisher's exact test showed a highly significant separation based on ER-status with p = 3.914e −12 .

The association of the western part of Eurasia (Central and West Asia and Europe) mtDNA types was extremely significant in haplogroup I ( P = 3.96E-12), haplogroup L ( P = 3.8E-17) and haplogroup N ( P = 6.35E-10) under the Pearson χ 2 test (Table 2 ).

This 3.8 fold difference was highly significant (t-test, p = 4 X10 -12 ).

In the combined sample, after adjusting for country of sampling, this sex difference is highly significant: males are on average more lightly pigmented than females by 1.57 M index units (95% CI = 1.14–2.01, p = 4×10 −12 ).

Overall, there were highly significant differences with medium to large effect size when comparing controls vs. patients (F(1) = 52.65, p = 4.05 × 10 −12 , ω 2 p = 0.15), visual areas (F(2) = 66.39, p = 2.88 × 10 −24 , ω 2 p = 0.3), and stimulus type (F(3) = 13.73, p = 2.27 × 10 −8 , ω 2 p = 0.11).

rs138213197 remained highly significant in this analysis ( P = 4.2×10 −12 , Table 1 ) and with an effect size substantially greater than that observed through any of the common variants and broadly similar to that previously reported in the literature (OR = 3.88, 95%C.I. 2.64–5.70).

And activated CD8 + T cells showed a trend of negative association with riskscore ( p = 4.3e-12, r = − 0.24) (Fig. 5 L).

The highly significant effect of relationship quality on MIPPE scores (p = 4.4e-12) demonstrates the scale’s discriminant capacity.

Overall, there was highly significant evidence of association between the minor allele at rs876498 and type 1 diabetes (OR 1.10 [95% CI 1.07–1.13]; P = 4.4 × 10 −12 ).

Comparison of this list with the top 20 genes from the original analysis ( Table 1 ) revealed 14 overlapping genes, a highly significant overlap ( p = 4.401E−12).

For instance, the highly significant "neurological process" (p = 4.45 × 10 -12 ) and their descendants (see Figure 2 ) are probably related to the undifferentiation process o neuronal cells.

A highly significant survival deficit was observed for pooled treatment ( SFB , n = 6 × 18) versus vehicle (DMSO, n = 2 × 18) of positive control groups by Fisher’s exact test ( p = 4.5 –12 ).

Of these, highly significant replications were marked for rs3812316, near gene MLXIPL ( P = 4.6 × 10 −12 ) and rs1150442 near gene EYA2 ( P = 1.4 × 10 −6 ) in the recent study of Pulit et al. 36 4.

Furthermore, the number of independent nominally significant loci at Stage 2 (N = 60, (13.5%)) was significantly greater than expected by chance (p = 4.6×10 −12 ).

The difference remained highly significant ( P = 4.8 × 10 −12 ).

This enrichment was highly significant (p = 4.8 × 10 −12 for mESC overlap; p = 2.3 × 10 −13 for hESC overlap) and constitutes a robust simplification of the Oct4 targets.

The BS platform was substantially more likely than ChatGPT-4o to correctly identify metastatic regions, and McNemar's test showed highly significant imbalances in discordant pairs, with p values approaching zero in lesion-level analyses (exact McNemar p = .0000000000048).

Only the standard ANOVA across the four-state system was highly significant ( p = 4.97 × 10 −12 , η 2 = 0.14) with the phylogenetic ANOVA and pairwise t -tests producing non-significant results ( figure 4 ).

The differences between the ‘early’ and ‘late’ are highly significant ( t ‐tests, p ‐value < 5e‐12 to p ‐value < 5e‐65).