Excerpts

These differences were highly significant by one-sample ANOVA (F = 16.1, p = 3.84E-13).

Once again an F-test was performed, looking for an effect of disease status in the presence of age and study site and allowing for an interaction between disease status and age; the result was highly significant (p = 4 x 10 −13 ).

The PNPLA3 rs738409 risk allele (G) remained highly significant, even when the two APOC3 variants were included in the model ( P = 4.06 × 10 −13 ).

The data were analyzed using log transformation of GDF15 levels ( Figure 2b ) and a highly significant relationship with the reciprocal of pre-pregnancy BMI was apparent (standardized β=0.266, p=4.1×10 -13 , n=721).This relationship was replicated in the NIPTeR Study ( Figure 2c & d ; standardized β=0.280, p=1.5×10 -5 , n=231).

All R values shown in the scatter plots were highly significant for SC and BP choices (SC&BP-graded regions in Fig. 5 c: R = 0.17, p = 4.3 × 10 −13 and R = −0.15, p = 7.8 × 10 −12 ; SC/BP-graded regions in Fig. 5 d: R = 0.26, p = 3.3 × 10 −28 and R = −0.19, p = 2.0 × 10 −21 ; SC&BP-graded parietal region in Fig. 5 e: R = 0.17, p = 2.9 × 10 −6 and R = −0.16, p = 1.3 × 10 −6 ; two-tailed Spearman’s correlation).

We use PROPER to predict multicopy suppression in Escherichia coli , achieving highly significant overlap with published cases (hypergeometric p = 4.4e-13).

As noted in the main text, this relationship is highly significant (Spearman's rho = −0.20, p = 4.75e-13).

The difference was highly significant (Kruskal–Wallis χ 2 = 63.7, df = 4, p = 4.9 × 10 −13 ).

Overall ANOVA for N = 6 independent experiments shows that the overall changes due to the presence of the blockers is highly significant ( p < 5 × 10 − 13 ).

The combined analysis of all four studies including a total of n = 1,910 cases and n = 3,630 controls showed highly significant evidence for association between rs1739843 and idiopathic DCM (p = 5.28×10 −13 , OR = 0.72 [95% CI 0.65–0.78]).

The age x genotype within sex interaction was also highly significant ( p = 5·5 × 10 −13 ).

The comparison of the fixed effects of the rs181206[G] allele resulted in highly significant estimates: β ^ m u t a n t = -1.11 ( P = 5.52x10 -13 ) for IRF1 and β ^ m u t a n t = -1.28 ( P = 4.86x10 -10 ) for STAT1.

A pooled dataset, consisting of 19 studies with long-term clinical follow-up, also demonstrated a highly significant (p= 5.80 × 10 −13 ) inverse correlation between DICER and hypoxia.

Each of these additive effects were highly significant (F statistic > 60, d.f. numerator , = 1, d.f. residuals = 175, p < 6 x 10 −13 ; Fig 4 ; Table 1 ).

Results In primary care, there was a negative trend in fluoroquinolone item dispensing, with a 4.2% reduction in items dispensed per year (95% CI −5.2% to −3.3%; P = 6 × 10 −13 ).

The most prominent peak was detected on chromosome 19 at position 45,281,163 bp, with a highly significant P-value of 6.03 × 10 –1 3 (-log 10 (P) = 12.22).

The coding region (CDS) of these genes also contained a highly significant enrichment for hexamer seed matches (p = 6.1E-13).

The overlap between early and late was highly significant ( p = 6.4e-13, Fisher test).

For example, we found highly significant functional enrichment among the interacting partners for the GO terms “cytoskeleton” (P value = 6.6 × 10 −13 ), “TFIID complex” (P value = 1 × 10 −14 ), and “proteasome” (P value = 6.6 × 10 −13 ) ( Haarer et al. 2011 ).

This difference in proportion Metazoan is highly significant (P = 6.91×10 −13 , Fisher's Exact Test); induced genes are also much more likely to be wasp-specific (31.3% induced, 16.3% other genes, Fisher's Exact Test P = 8.85×10 −7 ).

The ANOVA results revealed highly significant differences among treatments for both Tret1 ( p -value = 7.78 × 10− 13 ) and Tret1-like ( p -value = 1.32 × 10− 13 ), both far below 0.0001 significance p- value threshold, indicating that exposure to insecticides and acetone markedly affected gene expression.

Sylamer analysis using all 7-nt motifs complementary to seed regions of mouse miRNAs revealed a highly significant (P < 8 × 10 −13 ; Bonferroni corrected < 7 × 10 −10 ) enrichment for the 7-nt seed match of miR-451 (AACGGTT) in the 3′ UTRs of genes in a cohort of 588 genes, most of which were up-regulated in miR144/451 −/− erythroid precursors ( Fig. 4 B ).

For both models and both states, there are highly significant differences in importance values across the three classes of phenotypic impact (RF MN: P = 8.15 × 10 − 13 ; RF TX: P = 2.20 × 10 − 16 ; FFNN MN: P = 2.20 × 10 − 16 ; FFNN TX: P = 2.20 × 10 − 16 ).

The proportions were 0.962 ± 0.040 for AAV1-labeled neurons and 0.492 ± 0.066 for FluoroGold-labeled neurons, indicating a highly significant difference ( p = 8.6 × 10 –13 , Wilcoxon rank-sum test).

However, the death rate was 34% in co-infected ( n = 170) compared to non-co-infected patients ( n = 128), indicating a highly significant value ( p -value = 0.00000000000088).