Excerpts

A constructed PPI network based on these 18 proteins comprised 47 nodes and 137 edges, showcasing an average local clustering coefficient of 0.69 and a highly significant PPI enrichment ( P = 2.02e-13; Supplementary Figure S2A).

The impact of family on expression was highly significant ( F = 5.793, P = 2.06 × 10 −13 ), demonstrating that family membership plays a critical role in the variation of expression levels, especially for the UGT73 family.

Hence, the identification of 410 proteins is highly significant ( p = 2.15 × 10 − 13 ), and as such, is defined as a common interactome.

In the most comprehensive globally representative sample of Thoroughbreds to-date ( n = 10,118), including prominent stallions ( n = 305) from the major bloodstock regions of the world, we show using pan-genomic SNP genotypes that there has been a highly significant decline in global genetic diversity during the last five decades ( F IS R 2 = 0.942, P = 2.19 × 10 −13 ; F ROH R 2 = 0.88, P = 1.81 × 10 −10 ) that has likely been influenced by the use of popular sire lines.

Applying our method to a dataset from the Ludwigshafen risk and cardiovascular health study, we discovered a pair of SNPs with a near-significant interaction ( P = 2.2 × 10 −13 ), in only 1.5 h on 10 processors.

A weak ( r = 0.219) but highly significant ( p = 2.23×10 −13 ) correlation between expression of SOX2 and SOX2OT was found ( Figure 1 ), emphasizing the potential importance of this signaling pathway in human breast cancer.

Analysis of Molecular Dynamics Trajectories for Effect of Mutation on the Protein Structure Among the significant mutations, we found S194L in the N protein to be highly significant ( p -value = 2.35481E-13) and exclusive to the mortality patients.

These results generally confirmed our RF inferences; for example, bio8 was still a highly significant ( P = 2.40 × 10 −13 ; Table S3 ) predictor after correcting for genetic relatedness.

We identified a highly significant enrichment of imprinted genes involved in the placental somatic duplications (21/1,180 duplicated genes vs 214/57,952 Ensembl genes; P = 2.67 × 10 −13 ) ( Table 4 ).

In this analysis, we identified a highly significant overlap P-value with a positive correlation between the DG of adult Cn mutants (mutants vs. controls) and the DG of infant mice (2-week-old vs. 1-month-old) ( P = 2.7 × 10 –13 ; Fig. 3 d and e, Additional file 2 : Table S5), indicating a significant similarity in the gene expression patterns between them.

Specific KEGG Signaling Pathways and Common Peptides Further evaluation of three highly significant pathways ( P < 2.7 × 10 −13 ) showed that the T cell receptor pathway, TNF signaling pathway, and NF-B signaling pathways shared common peptides that were significantly different between jejunal samples from chickens on the control diet compared to those on the supplemented diet Table 5 . shows the significant peptides within the T cell receptor pathway, TNF signaling pathway, and NF-κB signaling pathways.

Influence of Phylogeny and Disturbance-Induced Thaw on ARGs Although the abundance of ARGs increased with FPES disturbance levels (UD = 101, SD = 133, MD = 145), we found the number of CARD hits per isolate was highly significant by phylum (Kruskal-Wallis p = 2.8 × 10 −13 ; Figure 3 a) rather than FPES site (Kruskal-Wallis p = 0.083; Figure 3 b).

Correlation between Hong Kong Red List and four traits At the national scale, Spearman’s rank correlation indicated a weak but statistically significant positive association between China Red List status and habitat ( r s = 0.153, P = 0.0062; P < 0.05), and a negligible yet highly significant positive correlation with trade ( r s = 0.009, P = 2.956E-13; P < 0.001).

The reduction of RUNX1 expression in high-grade tumors is highly significant (p-value = 3×10 −13 for the Ivshina dataset and p-value = 2.5×10 −9 for the Lu dataset by linear regression model analyses).

The difference was highly significant ( p = 3∗ e −13 ).

The brain showed an increasing trend in gene expression with age ( Tan module; bicor=0.86; p-value =3e-13), with the shift from down- to up-regulation occurring around the transition from middle- to old-age (15 to 18 months) ( Figure 3A , upper left panel).

Highly significant differences were also observed with PTPN14 ( p < 3.2e−13), SDC4 ( p < 3.2e−13), CKAP4 ( p < 3e−12), ADAM9 ( p < 3.3e−11), and PIK3CG ( p < 2.3 e−10).

The overlap between our data and all cancer types in TCGA was highly significant, both for miRNAs within a fusion transcript in at least one tumor (odds ratio 2.93, 95% CI [2.15–4.03], p = 3.29 × 10 −13 , Fisher’s exact test), for miRNAs recurrent in our data and with at least one fusion in TCGA (odds ratio 2.99, 95% CI [2.29–3.93], p < 2.20 × 10 −16 , Fisher’s exact test), as well as for miRNAs recurrent in both data sets (odds ratio 3.03, 95% CI [1.75–5.39], p = 2.62 × 10 −5 , Fisher’s exact test).

The linear correlation coefficient between the two mRNAs after log transformation was negative and highly significant ( r = −3.36, p = 3.34E-13).

Methylation changes within exons showed a weak but highly significant inverse correlation with changes in gene expression ( R = −0.043, P = 3.40 × 10 –13 ).

We found a highly significant main effect of stimulus modality on PSE shifts (Monkey M: β = 31.07, t (44) = 10.22, p = 3.412 × 10 −13 ; Monkey P: β = 6.044, t (44) = 8.457, p = 3.394 × 10 −9 ), as well as moderate evidence for an interaction between stimulus modality and self-motion amplitude (Monkey M: β = 733.5, t (44) = 3.016, p = 4.248 × 10 −3 ; Monkey P: β = 67.78, t (28) = 2.371, p = 0.02487).

We found that the protein products of genes within the WGCNA modules had highly significant functional interactions forming densely interconnected networks ( Fig. 14 A , mouseUP module, 1,136 nodes; average node degree, 8.2; PI enrichment p value = 3.56 × 10 −13 ; Figure 14 C , mouseDOWN module, 712 nodes, average node degree, 15; PI enrichment p value < 1.0 × 10 −16 ).

Rank correlation coefficients suggest that the coincidence between temperature- and retinal sensitivity is highly significant among TM2 variants (ρ = 0.37. p = 3.6 × 10 −13 ) but not among TM7 variants (ρ = 0.01, p = 0.79).

We found a positive trend ( R = 0.53, P -value = 3.7e–13, Spearman) between the abundance of low-complexity TASPLIVR-rich proteins and A34-tRNA gene content (Figure 10C and Supplementary Table S6 ).

In addition, we found evidence of high GNA12 expression in multiple sets of colorectal RNA-seq data ( GSE107593 : P = 7.48 × 10 −9 , LogFC = 0.42; GSE117993 : P = 6.76 × 10 −7 , LogFC = 0.27; GSE166925 : P = 1.09 × 10 −3 , LogFC = 0.52) and suggested an elevated trend in myeloid cells ( GSE162335 : P = 3.71 × 10 −13 , LogFC = 0.42).