Excerpts

We first tested the impact of PRS 231 in the QFS discovery sample and results demonstrated a highly significant association with obesity (OR trend = 1.24, 95% CI = 1.17-1.31, P = 1.03x10 -13 ).

At TEA, the difference between infants with c-PVL and controls was highly significant, and no interaction with PMA was found (left P = 1.08*10 −13 and right P = 2.7*10 −13 ).

However, the high similarity within the groups, the large, highly significant difference between groups ( p = 1.1 × 10–13 for LF band, p = 4.5 ×10–14 for LF band) and the high reliability of several clustering approaches strongly indicate that such a bias would not substantially influence our outcomes.

Our multivariate linear regression model was overall highly significant (p = 1.10E-13; F = 15.71 on 9 and 70 degrees of freedom; adjusted r 2 = 0.63) and the residuals of the regression for the adhesive force were found to be normally distributed (p = 0.88; W = 0.99).

Furthermore, statistical analysis revealed a highly significant difference in prediction scores before and after mutation ( P < 1.1 × 10 −13 ), indicating that mutations significantly affected prediction scores in most samples, with the observed reductions strongly correlated with alterations at the CDR3–epitope binding interface.

Highly significant Day × Carnosine interactions were observed for all three mutant strains ( otsA , P = 1.10 × 10 −13 ; glgA , P = 1.22 × 10 −9 ; glgA otsA , P = 4.44 × 10 −13 ), demonstrating carnosine’s strong protective effect on competitive fitness.

The p -value reported by the Friedman test is still highly significant ( p < 1 ⋅ 10 −13 ), but Shaffer’s static method could only separate the classifiers into two groups.

aegypti ITS1 T p against the natural logarithm of overall DNA concentration was found to be highly significant (p = 1.2 e-13) with an adjusted R 2 of 0.918 and a regression coefficient of -1.391 (S.E. 0.086).

The ANOVA for GRI (day −1 ) indicated a highly significant effect for treatments (F = 16.89, p = 1.28e−13), however genotypes and genotypes × treatments interaction showed non-significant effects.

The Q test (Tukey HSD [honestly significant difference]/Kramer) and post hoc ANOVA (analysis of variance) test showed a highly significant improvement in the control score at 6 months compared with the initial evaluation ( P = 1.29E-13) and between the initial assessment with the 12 months later ( P = 2, 65E-11).

Tukey’s multiple comparison tests normalized to oil vehicle control innervation volume (1.0 ± 0.040, n = 13) reveals the expected highly significant innervation volume pruning with the stronger 25% EB critical period experience (0.150 ± 0.044, n = 10; q (39) = 20.56, p = 1.3 × 10 −13 ; Fig. 4 B, left).

Spearman correlation analysis indicated a moderate (R = 0.206), but highly significant, correlation for S ( p = 1.37e-013), though no correlation was noted for N (R = −0.092, p = 6.70e-002) (Fig. 1C, D ).

The correlation between oligochaete densities determined before and after addition of absolute ethanol was highly significant ( R 2 = 0.996, p = 1.4∗10 −13 ) ( Fig.

Statistical analysis using a two-sample t -test assuming equal variances revealed highly significant differences: SMRmut vs. #61 ( p < 1.47 × 10 −13 ), SMRmut vs. #62 ( p < 1.45 × 10 −13 ), and SMRmut vs.

The hits on the two plates showed a large and highly significant overlap given the total number of tested compounds (Jaccard index of 0.78; χ 2 test of independence: P = 1.5e−13).

Consistent with this, a phosphoproteomic analysis showed that the changes in phosphorylation induced by siRNA-mediated depletion of NUAK1 in U2OS cells showed a statistically highly significant overlap with changes induced by BAY-880 ( Figure 4 D; p = 1.5 × 10 −13 ), and a GO term analysis of changes of differentially regulated phosphosites showed that processes targeted by BAY-880 highly overlapped with the ones targeted by depletion of NUAK1 ( Figure 4 D).

The Kruskal-Wallis test for success rate showed a highly significant effect of treatment (χ2 = 69.07, p = 1.60 × 10−13), and pairwise comparisons confirmed that CTAB and HotSHOT performed significantly better than other methods, including Chelex and Tween.

Although there was no transcriptome-wide correlation between ZC3H11 binding and the RNAi effect (Supplementary Table S1 , sheet 5), every single one of the ZC3H11-bound heat-shock chaperone mRNAs was decreased in the RNAi cells ( Table 1 ): the enrichment of chaperones in the subset that was both ZC3H11-bound and reduced in heat-shock was highly significant (P = 1.6×10 −13 ) (Supplementary Table S1 , sheet 7).

There was also a highly significant enrichment of genes involved in response to bacteria and lipopolysaccharide (e.g. the category “Response to lipopolysaccharide”, P = 1.69 × 10 −13 ).

A highly significant difference (P=1.71E−13) in OS was discovered between two groups.

This difference was highly significant (t = 12.58, p = 1.7154E-13) and was associated with an exceptionally large effect size (d = 3.68).

As regards the analysis of deviance performed on fertility data ( Table 1 ), irradiation dose showed a strong and highly significant negative effect on fertility (χ 2 = 54.17, p -value = 1.8 × 10 −13 ***), whereas only a weak tendency was detected for the interaction term.

These differences in central tendency were supported by a highly significant Kruskal–Wallis result ( χ 2 = 62.36, df = 3, P ≈ 1.8 × 10 −13 ).

A highly significant enrichment of transcripts from the pattern A are found in CD4+ (adjusted p = 1.9 × 10 −13 ) and CD8+ T-cells (adjusted p = 3.8 × 10 −12 ).

Although there were no genome-wide significant associations for VSMC proliferation or migration, genetic variants at two genomic loci (7p15.3 and 7q32.3) showed highly significant associations with VSMC apoptosis ( P = 1.95 × 10 −13 and P = 7.47 × 10 −9 , respectively).