Of these, 31 genes appeared in both lists, with the change occurring in the same direction, a highly significant convergence (Fisher Exact test p = 1.9 × 10 − 14 ; Fig. 1 a).
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All exposures showed at least nominally significant associations with increased mortality, most significantly for SBP (HR, 1.04; 95% CI, 1.03-1.06; P = 1.9 × 10 −14 ); the association of WMH with mortality was no longer significant after adjusting for educational level or interim stroke status (eTables 9 and 10 in Supplement 1 ).
Two linkage blocks within the Waxy locus (5034 bp in length) reflected an unusual LD decay within the gene, and the first block contained a highly significant T→G splice variant at 1 765 761 bp (−log( p ) = 13.72, β = −0.74) lying in 5′end of intron 1 (LOC_Os06g04200.1) (Figures 3 a and S4 a,b).
The multivariate analysis demonstrated that FH expression retained a highly significant effect on the angiogenesis score ( p = 1.97 × 10 −14 ), independent of age, tumor size, or molecular subtype. 3.3.
BS and TCB did not differ significantly among years (BS: χ 2 = 1.0, df = 6, P = 0.9847; TCB: χ 2 = 0.3, df = 8, P = 1), whereas ST showed a highly significant year effect (χ 2 = 63.1, df = 2, P = 1.984 × 10 −14 ).
We subjected the top 200 variant genes to GO (gene ontology) term analysis and found a highly significant over-representation of terms such as spermatogenesis ( p = 2E−14), mitosis ( p = 5E−6) and meiosis ( p = 1E−3).
The over-representation of human clinical isolates in the C clade was highly significant (P = 2.001×10 −14 , Fisher's exact test), and of the remaining 13 clinical isolates nine segregated within the E clade and four in the A clade.
In addition, there was a significant trend toward higher PC1 values in the order of healthy controls, CMD-free IBD patients, and CMD-affected IBD patients ( P = 2.24 ×10 −14 in a Jonckheere-Terpstra test among the three groups, P = 0.0345 between CMD-free and CMD-affected IBD patient groups).
Results: Logistic regression analysis showed a highly significant effect of the haplotype ranks in the outcome of a search in BMDW (p=2.25e-14).
Only one locus, IL23R , demonstrated true independence of the psoriasis SNP; the PsA-associated SNP rs12044149 remained highly significant ( P = 2.4×10 −14 ) after conditioning on the psoriasis SNP, rs9988642, and the addition of rs9988642 did not improve the model fit with LRT ( P = 0.21).
Although the mutations were likely to be located in the middle or downstream region of the RBP binding sites, the distance between the mutations and the start sites of RBP binding sites showed a marginal trend of negative correlation with the functional impact of these mutations (R = ‐0.02; P = 2.50e‐14).
The difference was highly significant (ANOVA F = 49.74, p = 2.7 × 10−14) and clinically meaningful, reflecting a reduction of nearly three days with earlier NPWT initiation (Table 1 , Figure 1 ).
This polymorphism showed a highly significant risk effect on fibrogenesis, with an OR of 9.2 in the NAFLD/MASLD cohort ( p = 2.7 × 10 −14 ) [ 13 ].
10 b), and the Wilcoxon test showed that the ionic bond changes between the positive and negative variants were extremely significant ( p = 2.7E − 14).
This difference was further confirmed by a Mann–Whitney U test with continuity correction, which demonstrated a highly significant difference in absorbance distributions between the two strains ( W = 36,316, p = 2.846 × 10 −14 ).
A notable example was the highly significant cASE observed in SLC30A8 (rs11558471; p = 2.9 × 10 −14 ), which showed colocalization with a well-established T2D-associated variant ( Figures 5F and 5G ; Table S5 ) for which there was no eQTL colocalization.
This number suggests a highly significant association between UCSs and AS-NMD (Fisher’s exact test, P = 2.9 × 10 −14 ).
6 B ), along with the highly significant positive correlation (Pearson's correlation, r = 0.98; p = 3.1 × 10 −14 ; N = 19) between them, confirms the model's reliability as a KE estimator for any trajectory defined in either the hand space or the joint space, within the context of the current 2D movement setup.
The three-way interaction involving time as modelled by the B-splines, genotype and treatment was found to be highly significant ( P = 3.267e −14 ).
A GWAS for LSK cells revealed several suggestively associated loci, including those on chromosomes 2, 4, 6, and 18, as well as a highly significant (p = 3.7 × 10 −14 ) locus on chromosome 15 ( Figure 2 B; Table 1 ), where the lead SNP (rs31675052) is located approximately 100 kb downstream of Ly6f ( Figure 3 B).
A highly significant correlation was observed between SETD2 and H3K36me3 immunohistochemical staining ( P =3.8e-14, Cochran-Armitage test, Supplementary Figure S3a ), suggesting that absence of H3K36me3 staining is a good surrogate for SETD2 loss-of-function. 8 DNA damage was assessed by staining for phosphorylated his
For T1D, the white UK Biobank British PRS models was highly significant ( P = 3.8 × 10 −14 ) with outstanding predictive performance in white British ancestry; however, the predictive performance was significantly worse when transferred to individuals of African or South Asian ancestry.
HG was also highly significant ( p = 3.841 × 10 −14 ).
For example, we find that co‐regulation of transcripts and proteins from closeby genes is more common than for random protein pairs (Fig 1 B), and this enrichment is highly significant (3% versus 0.4%, P < 4 × 10 −14 ).
While these showed highly significant association ( p = 4.05×10 −14 for both markers) in the control group, in the temperature treated group neither marker was significantly associated after correction for multiple testing ( p = 0.039 for both markers).