Excerpts

3C ), with the Kolmogorov-Smirnov test revealing a highly significant difference in the two distributions (p = 2.2×10 −16 ).

andersonii (tested via independent samples Wilcoxon rank-sum test), while its F is value was also significantly lower ( P < 0.05).Furthermore, verification of Rarefied Allelic Richness (Ar) via the Kruskal-Wallis rank sum test revealed a highly significant difference between the two species (chi-squared = 1770.3, df = 1, P < 2.2e-16), confirming that the genetic diversity of B. andersonii is robustly higher than that of B. tianguii even after standardizing sample sizes ( Figure 3 ). 3.3.

All reported correlations were highly significant ( p < 2.2 × 10 −16 ).

We observed a highly significant gain of methylation with age at the locus in the LBC cohort, validating our approach (Fig. 1 a, T-test, p < 2.2 × 10 −16 ).

A highly significant correlation (R 2 = 0.94–0.96, P < 2.2e-16) confirmed the accuracy of the 3D scanning method ( Fig.

As a result, we found a highly significant positive relationship between visual bleaching scores on Day 0 and Day 7 post-stress ( Fig 3A and S2 Table , linear mixed effects model, p < 2.2e -16 , marginal R 2 = 0.863, df = 44), such that VBS at Day 0 post-stress was highly predictive of VBS throughout the following seven-day period.

A clear trend is observed between symmetry [ 35 ] of eruption in the upper and lower arches ( p -value < 2.2 × 10 −16 ); therefore, the probability of a child having symmetry in the lower arch while he also has upper symmetry (and vice versa) is high.

Finally, we observed a highly significant increase (one-sided Student’s t -test, p = 2.2 × 10 −16 ) in average epistasis values in the winning CR genotypes compared with the overall population, indicating that positive epistasis plays an important role in determining the fittest genotypes in this selection (Fig. 5b ).

This comparison also revealed highly significant, albeit slightly weaker correlations (Pearson correlation 0.73; P <2.2e-16; Figure S11 ) – similar to the results we obtained for chromosome 1 CNVs.

Figure 8 shows a highly significant inverse relationship between the developmental rank of a gene and its overexpression frequency ( p < 2.2e-16).

The overlap was highly significant, with 30% (1095/3647) of SEM CpGs found to be among NRBC-associated CpGs ( p < 2.2E−16).

In B to A and no-change category, a significant (Fisher’s test p-value = 0.0564) number of genes were found to be changing gene expression, while the number of genes changing expression in A to B and conserved genome category was found as highly significant (Fisher’s exact test p-value < 2.2e-16) ( Figure 4C ).

Notably, the relaxed (R) state showed highly significant differences ( p < 2.2 × 10 −16 ) from all other emotional states across all features.

Subsequent statistical analysis revealed a highly significant ( p < 2.2 × 10 −16 ) cell cluster composition between the baseline sample NI Day + 0 ( n = 217 cells) compared to differentiated samples S Day + 15 ( n = 577 cells) and SON Day + 15 ( n = 400 cells) as well as between the differentiated samples ( Figure 3 C, Table S5 ).

The overall percentage of HG disease was highly significant, with a hazard ratio of 4.45 for the interquartile range (95% confidence interval 3.30–6.01, P < 2.2 × 10 −16 ), and was similar to the percentage of HG disease seen in the worst core.

For both the OE and VNO, the correlation values were highly significant ( P < 2.20 × 10 −16 ), and the correlation coefficients between samples from the same subspecies were higher than those found between samples from different subspecies ( Supplementary Table S5 ).

We report a highly significant positive correlation between the exon length and number of homologous exons (Figure 4 , Kendall’s τ = 0.133, p-value < 2.2e-16) suggesting that isolate/species-specific genes tend to be shorter.

The latter explanation is supported, because there is a highly significant between-haplotype component of variation for the trait ( P < 2.2 × 10 −16 for the whole data set; P between 4.1 × 10 −13 [L14] and 0.022 [L06] for the individual MA lines).

In addition, CREB1 is the top upstream regulator of the 465 overlapping differentially expressed genes (see previous texts) and there is a highly significant, negative correlation ( r = − 0.91, p value = 2.2E−16) between the fold changes for these genes—including the 58 direct CREB1 target genes—in the two comparisons (Supplementary Fig. 3 ).

The reversal DEGs obtained from the dataset for each cell type were highly significant, based on empirical null distribution (B cells: n=24, p-value <2.2×10 −16 ; CD4+ T cells: n=67, p-value <2.2×10 −16 ; CD8+ T cells: n=108, p-value <2.2×10 −16 ; monocytes: n=183, p-value <2.2×10 −16 ; NK cells: n=66, p-value <2.2×10 −16 ) ( supplementary figure S5a–e ).

In fact, among the 291 genes selected for pad4 , 170 genes are also included in those for sid2 : the overlap was highly significant ( p < 2.2 x 10 -16 , Fisher’s exact test).

The overall model including all predictors was highly significant for both, the plaque size in the aortic root and BCA (BCA: F(4, 94) = 37.44, p-value < 2.2e-16 r2 = 0.60; heart: F(4, 81) = 65.09, p-value < 2.2e-16, r2 = 0.75).

Despite major differences in experimental design, including the developmental stage of the worms, the overlap with the single-cell cis eQTLs was highly significant, with 335 cis eQTLs shared between the studies (OR = 7.2, p < 2.2×10 −16 , Fisher’s exact test) ( Figure 3C ).

The 138 c-Jun-regulated genes showed a highly significant 5.8-fold enrichment (p=2.2×10 −16 ) among the 1581 genes regulated during chronic denervation.

Strikingly, PFC Aliceblue and NAc Cadetblue 2 showed a highly significant overlap in their gene content, with 72 overlapping genes ( S2 Table ; p = 2.2 x 10 −16 ).