Excerpts

In both cases the difference in expression level was highly significant ( p < 2.2e-16) indicating that the coverage of those genes was too low for an assembly of at least 55% in one species.

Furthermore, a linear model comparing the paired connectivity estimates from the 24-particle and 1-particle-per-day scenarios revealed a highly significant (p < 2.2e-16) and remarkably strong linear relationship, closely approaching a 1:1 correspondence (R-squared = 0.999; Fig. 3 ).

From 274 qRT–PCR experiments, a highly significant relationship was observed between these qRT–PCR data and stage-matched FPKM values (log 2 (qRT-PCR) versus log 2 (FPKM) linear correlation coefficient = 0.54, P < 2.2 × 10 −16 ).

This comparison resulted in 196 common antigens out of 481, a highly significant overlap (odds ratio: 6.4088; 95% CI: 5.3011–7.7479; chi 2 p -value < 2.2 × 10 −16 ).

This targeting is highly significant as compared to the targeted human proteome counterpart (exact Fisher test, p value <2,2×10 −16 ).

These results show, that RNAs with diminished abundances in the mutant possess a particularly high amount of cleavage sites, which was also indicated as highly significant by hypergeometric test (enrichment over background distribution of cleavage sites: 6.23-fold; p-value <2.2 −16 ).

Lastly, we compared the average TE ages between SUO and SLO genes in human and revealed a highly significant difference (p<2.2e-16, Wilcoxon Rank Sum test), with the former at 16.1% and the latter at 21.3% sequence divergence from their consensus sequences (For reference, 16–18% of unconstrained nucleotides have been substituted since the split of primates from other mammalian orders [32] ).

Pearson's Chi-squared test showed that this difference is highly significant ( P < 2.2e − 16).

Conservation and compensation of phosphosite loss by site-position turnover Surprisingly, despite the low level of site-conservation between paralogous proteins, there is a highly significant correlation in the number of phosphorylation sites between paralogs (ρ=0.35, P -value<2.2 × 10 −16 ; Figure 1B ).

The results of the statistical linear regression between RSSI and the logarithm of the node-gateway distance (logD) are robust and highly significant (R2 = 0.808, p -value < 2.2 × 10 −16 , residual standard error = 10.68 dBm).

Additionally, there was an increasing trend in the TMEscore from IE to IS to IA, with IA showing the highest TMEscore (both p < 2.2×10 −16 , Figure 2F ; p < 2.2×10 −16 , p < 2.2×10 −16 , and p = 3.6×10 −10 , respectively; Figure S2B , Supporting Information).

These differences, while modest in strength, were highly significant (p < 2.2e-16).

We find a highly significant departure from the expectation that the mean blunting score is equal to zero (two-tailed one-sample t test P < 2.2 × 10 −16 ), demonstrating that deletion of ENH5 results in a transcriptome-wide dampening of the response to sustained hypoxia ( Fig. 3E ).

The model describing recovery rate ( rr ) was highly significant ( X 2 = 27,605,272, df = 23, P< 2.2e -16 ), with each term of the model being significant ( S2 Table ).

For all three species comparisons, a linear regression of %ID and log 2 hybridization ratio showed a strong and highly significant correlation ( D. sechellia : Multiple R 2 = 0.3257, P < 2.2e-16; D. simulans : Multiple R 2 = 0.2920, P < 2.2e-16; D. yakuba : Multiple R 2 = 0.4083, P < 2.2e-16) (Figure 2 ), with the data for D. yakuba showing the strongest correlation.

This difference in size between the three types was highly significant for both length ( F = 328.7, df = 368, p = 2.2e‐16) and weight ( F = 478.2, df = 368, p = 2.0e‐16), with highly significant differentiation between even the closest two types (kokanee and hybrid; length: F = 20.3, df = 301, p = 9.51e‐0; weight: F = 44.61 df = 301 p = 1.16e‐10).

Wilcoxon rank sum test with continuity correction revealed highly significant changes for old versus young cortex and hippocampus circRNA TPM values ( P < 2.2 E-16) ( Fig. 2d ).

The mean values of the non-invasively measured community-wide parameters obtained by DWCP seem to give a valid representation of the actual plant community as indicated by the highly significant positive relationship between the weighted plant biomass removed from sods and the digital biomass extracted from scans (quadratic polynomial regression, p < 2.2e-16, adjusted R 2 = 0.59, see Additional Figure 3 ), supporting results from scans of plant individuals ( Laxman et al., 2018 ).

Biological age showed a highly significant Pearson’s correlation with chronological age of 0.98 ( p -value < 2.2e − 16) (Fig. 2 a).

Analysis of application inflow Davies‘ test for significance of breakpoints resulted in a highly significant change in the slope of the participant inflow ( p -value < 2.2e − 16 ).

SNPs rate at GRDs (rate = 0.053 synonymous SNPs per site) was 36% higher than this rate at GRSs (rate = 0.039 synonymous SNPs per site), and the difference was highly significant (Wilcoxon rank test: P < 2.2 × 10 −16 ).

Given the large ExAC data sets sampling 60,706 individuals, the differences were extremely significant (p-value < 2.2e-16).

magna SGR and was highly significant ( p < 2.2 × 10 −16 ; see Table 2 for additional information).

The model revealed highly significant main effects of total body length (log 10 TBL) ( F = 3335.41, p < 2.2e‐16), indicating that mandible length strongly and predictably scales with overall body size.

As expected, we observed a highly significant difference between RefSeq mRNAs (NM) and RefSeq non-coding RNAs (NR) for both the CPC and the RNA-code score (CPC t = 56.4326 [2.239631;2.400904], p-value<2.2×10 −16 , RNAcode t = 39.6171 [34.44711;38.03595], p-value<2.2×10 16 ).