Barely Significant

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This cumulative effect was further supported when combined individuals with one or two PD-susceptible genotypes (OR = 2.53, 95%CI = 1.21–5.27, p = 0.0165), and those with three or four susceptible genotypes (OR = 3.93, 95%CI = 1.83–8.43, p = 0.0004), with a significant trend across subgroups ( p for trend = 0.0009, Table 5 ).