Excerpts

However, after conducting procedures that contemplated the potential of confounding effects, results were always highly significant.

This coupled with the up-regulated activities of the IFN-γ/Stat1 pathway and the increase concentrations of TNF-α and IFN-γ may be significant as this suggests possible T cell exhaustion from constant exposure to tumor antigens or the absence of the HLA-A2 allele 44 45 46 47 .

Tfr2 alpha protein in total brain extracts showed a trend to decrease in WT IDD mice compared to WT mice, while it did not vary in WT IED animals ( Fig. 1B ).

The changing patterns of fecal microbiota after treatment showed a trend to restore the healthy microbiota.

Thus, at least with this level of analysis, we do not see an increasing trend of selective delay period activity over the course of our recordings.

amblycephala were predicted for the 420 known miRNAs and 41 novel miRNAs including 362 highly significant differently expressed miRNAs.

9 and Table 3 ), revealing a decreasing trend with increasing temperature.

In addition, likely due to greater power from the slightly larger sample size, weighted UniFrac analysis also showed marginally significant differences.

Baratz and colleagues described the results of a genome-wide association study (GWAS) that revealed a highly significant association between single nucleotide polymorphisms (SNPs), most notably rs613872, in the transcription factor 4 (TCF4) gene and typical, late onset FCD 22 .

However, precipitation extremes are a local phenomenon that displays a significant trend in spatial variability over India in the recent decades 28 .

The multimodal mean of precipitation extremes during a historical period, i.e., from 1951–2005 shows an increasing trend.

Dough quality testing of 102 wheat cultivars established a highly significant association of the type-1 TaALP-7A allele with better wheat processing quality.

In FLO-1 cells there was an observed trend toward the center of the nucleus with vorinostat exposure, but this variation did not meet our criterion for statistical significance (p = 0.06).

While low and pulse dose follow the same dynamic expression for wnt11 as control, the high dose group appeared to have lost this regulation and instead showed a trend of overall increased expression at most time-points.

Furthermore, omitted variable bias, or unaccounted confounding, can result in highly significant but spurious results in observational studies 24 .

Nevertheless, in this context, the additional copy of the PPP1R13L gene observed in samples from the European population may be significant for the progression of liver injury and the severity of CHC.

For the whole period, despite some differences among three reanalysis products, they all indicate an increasing trend over China.

Over the course of three years, we found a highly significant decrease in the rate of Botrytis infection.

Dry matter percentage showed an increasing trend, with values ranging from 9.0% at the beginning of the harvesting period to 12.9%, on average, at the end, without differences between “Unbiofortified’ and ‘Biofortified’ treatments.

A highly significant inverse correlation between the presence of CRISPR-Cas loci and acquired antibiotic resistance was revealed in 48 Enterococcus faecalis strains 8 .

Quantitative analysis confirmed that 4 hr nocodazole treatment induced focal adhesion assembly, as shown by the shift in distribution, and that this increase in adhesion size was highly significant (p-value 3.08 * 10 −192 and 3.95 * 10 −277 , for pTyr118-paxillin and vinculin, respectively).

In any case, the results here are very promising as they establish a clear trend for the enhancement of polymer–graphene composite stiffness, as experimentally relevant graphene flakes have sizes that are typically in the sub-micron range.

Our mean dipole localisations showed a trend that is consistent with these known origins, especially for the left hemisphere, but our beamformer localisations did not.

Thus, we extended our analysis to nominally significant genes but very little overlap was again highlighted at the 3 time points investigated, confirming that most of the genes regulated by Tob1 are cell-specific ( Fig. 5a ).

The higher total HBV RNA also showed a trend toward association with IFNα treatment failure, though it was not statistically significant ( Fig. 3B ).