Excerpts

Both main effects were also highly significant for Group: F(2, 228) = 52.02, p < 0.0001 (22.84% of variation) and Tissue region: F(2, 228) = 49.99, p < 0.0001 (21.95% of variation).

We found a highly significant correlation for the oligomers generated from both HypF-N (r = 0.93, P < 0.0001) and Aβ 42 (r = 0.95, P < 0.0001).

This analysis showed a highly significant positive correlation between the two datasets for both the SLC transporters (r = 0.9157, P < 0.0001) and the ABC transporters (r = 0.8368, P < 0.0001) (Fig. 3 , Supplementary Tables S3 and S4 ), providing further confidence in our approach.

500 nM Aβ 1–42 ), 23.1 ± 2.4% (mean ± SEM; n = 23) of wild type dendritic spines were associated with amyloid-β-immunoreactive puncta, whereas in contrast spines from p75 NTR ko neurons showed a colocalization ratio of only 6.9 ± 1.1% (mean ± SEM; n = 24), a difference that was statistically highly significant (p < 0.0001).

The logistic regression model showed orographic lift to be a highly significant predictor of the probability of low altitude soaring (Wald test, p < 0.0001).

One-way ANOVA statistical analysis also established that there existed an extremely highly significant difference ( p < 0.0001) among the test concentrations.

Stake size’s effect on cooperation rate in each role was highly significant in the first three roles (generalized linear mixed model analysis: simultaneous role, F (2, 1434) = 82.90, P < 0.0001; first player role, F (2, 1434) = 76.88, P < 0.0001; second player role in which the first player cooperated, F (2, 1434) = 32.04, P < 0.0001).

Furthermore in the hanging wire grip test requiring strength and coordination the FE65/FE65L1-DKO mice had a significantly lower latency to fall compared to WT mice, while single KOs, which also showed a trend towards a lower latency to fall, were not significantly different from WT mice ( Fig. 1c , p = 0.0001).

Regression coefficients and factor significance The full quadratic model’s ANOVA (Table 4 ) revealed a highly significant overall fit (F = 15.29, p < 0.0001), with R2 = 0.934, adjusted R2 = 0.879, and predicted R2 ≈ 0.65.

This difference was statistically highly significant (df = 1, n = 20 animals per group, log rank analysis, chi 2 = 22.73, Hazard ratio = 0.36, p < 0.0001).

As tested by in vitro germination and acetocarmine tests, the analysis of variance clearly showed that storage method, days of storage, and the interaction between storage methods and days of storage had a highly significant effect ( p ≤ 0.0001) on pollen viability.

Statistical analysis indicated highly significant differences ( p < 0.0001) between N3 and N3-O formulations, confirming that sonication significantly enhances the antimicrobial activity of Ni2CoS4 HSs across both Gram-positive and Gram-negative pathogens.

However, the difference between both normal melanocytes and skin, as well as between tumor samples and skin, was not only highly significant (adjusted p -values < 0.0001) but also substantially larger in magnitude, as shown in Fig. 2 E.

60 min: adjusted p = 0.151) or marginally significant (e.g., 70 vs. 50 min: adjusted p = 0.0001), and declined slightly thereafter.

3 , JO146 treatment resulted in complete or highly significant (p < 0.0001) loss (up to 10 3–4 log) of progeny (IFU) when added during the replicative phase.

The fitted GLMM was highly significant with group Test (β = 0.25, t = 3.8, p = 0.0001, 95% C.I = [0.12, 0.38]) and action ‘flap wings’ (β = -0.27, t =-2.5, p = 0.02, 95% C.I = [-0.48, -0.06]) correctly predicting the response rate.

Moreover, the Wilcoxon rank-sum test reveals that the differences in microbial diversity between these two ecosystems were extremely significant ( p -value < 0.0001).

At univariate analysis MS was strongly associated with education with a significant trend (chi square 23.5; p-value 0.0003) reaching a strongest positive association for university degree (OR 6.87; 95%CI 2.90–16.20; p-value < 0.0001); MS was also positively associated with history of mononucleosis and inversely associated with history of autoimmune diseases as reported in Table 2 .

The association between obese and CRC in overlapping DMRs was highly significant as suggested by Chi square test (p < 0.0001).

Results In the exploratory phase, WFNS and age were shown to be highly significant predictors for the outcome (p < 0.0001 for both).

Figure 3 shows a highly significant differences in methylation levels between risk allele carriers and non-carriers (P < 0.0001).

In the medium group size (6SC), the CNTRL + M + 6SC showed a highly significant increase in mirror bites compared to HGRY + M + 6SC ( P < 0.0001).

A highly significant correlation of cytoplasmic survivin staining was observed with higher Gleason Scores and advanced pT stages (p < 0.0001 each, Table 1 ).

In rats (n = 4), four out of five studies with one study reported on VLDL level instead of LDL level, reveal a highly significant reduction in LDL (SMD = − 4.847, p < 0.0001) and CI for this effect ranges from − 5.693 to − 4.002.

Moreover, given the highly significant differences in the changes of the apoptotic marker Cleaved-Caspase3 across groups following CypD expression modulation (both P < 0.0001), it is suggested that cell death may be the primary cause of the decline in cell viability.