Excerpts

Analysis of variance (Table 3 ) revealed that the reduced quadratic model was highly significant ( p < 0.0001), with a non-significant lack of fit, a high correlation coefficient (0.9726), and a high adequate precision ratio (APR) of 16.48.

Response Surface Methodology identified these factors as highly significant ( p < 0.0001) and yielded a robust predictive model (R2 = 0.9869).

control) and years were highly significant (treatment: df = 1; χ 2 = 22.18, P < 0.0001; year: df = 2; χ 2 = 824.73, P < 0.0001), while the interaction (treatment × year) was not significantly different (df = 2, χ 2 = 4.03, P = 0.1332).

The frequency of clinch attacks showed a trend for diminishing along the exposure trials [F (1,18) = 33.72, p < 0.0001; F (2,36) = 2.9, p = 0.07 for genotype and trial sequence effects respectively, in 2way RM-ANOVA].

Statistically significant results were found to have a P value < 0.01 is statistically significant, a P value < 0.001 highly significant, a P value < 0.0001 strongly significant 105 .

The overall CIA score difference was also calculated as a cumulative effect on the experiment termination day (day 51), which showed highly significant improvement ( p < 0.0001****) in both the peptide 10 mg/kg group and the 5 mg/kg group.

Beta diversity analysis reveals a highly significant difference in community membership between the breast and skin tissue microbiota, as indicated by unweighted UniFrac analysis (MiRKAT P < 1e-4, Fig. 2E ), but the difference is not significant in weighted analysis (MiRKAT P = 0.14, Fig. 2F ), indicating that the major difference lies in the rare or less abundant lineages 22 .

Furthermore, the increase of percentage of centralized nuclei remained highly significant at the ages of 3 months (F (1, 24) = 60.27, p < 0.0001), 5 months (F (1, 28) = 66.91, p < 0.0001) and 10 months (F (1, 24) = 74.14, p < 0.0001), until the age of 15 months (F (1, 24) = 63.22, p < 0.0001).

AUSTRAL medium) had a highly significant effect on the variability of SBF indexes (Wald = 83.73, **** P < 0.0001) (Table 2 ).

The biodistribution analysis confirmed a highly significant uptake of the radiotracer in the ischemic region of the myocardium 2 h pCI (19.46 ± 2.26% ID/g, P < 0.0001) and 4 h pCI (9.16 ± 2.03% ID/g, P < 0.0001) compared to 5 min pCI (3.2 ± 0.67% ID/g) and the sham-operated animals (2.46 ± 0.84% ID/g, Fig. 1d ).

Histograms indicated a highly significant increase in mean NAVs after stimulation with 2 or 10 nM iloprost ( p < 0.0001) for those phosphopeptides with PKA consensus site versus no such site (Suppl.

The repeatability of measurements between observers was highly significant (R = 0.914, CI = 0.866, 0.945, p < 0.0001) and the variation in gametocyte densities within each extremity of each individual represented only 0.01% of the variance.

60 min: adjusted p = 0.151) or marginally significant (e.g., 70 vs. 50 min: adjusted p = 0.0001), and declined slightly thereafter.

500 nM Aβ 1–42 ), 23.1 ± 2.4% (mean ± SEM; n = 23) of wild type dendritic spines were associated with amyloid-β-immunoreactive puncta, whereas in contrast spines from p75 NTR ko neurons showed a colocalization ratio of only 6.9 ± 1.1% (mean ± SEM; n = 24), a difference that was statistically highly significant (p < 0.0001).

Normalized mean expression levels detected by qPCR and RNA-Seq showed a strong correlation, as ascertained by highly significant ( P < 0.0001) Pearson’s coefficient ( r = 0.91; see Supplementary Fig.

When comparing users to their friends, this correlation is highly significant with a p ≤ 10 - 4 .

Segregating the mice by sex exposed a 4.75-fold increase of Wnt signaling activity in male LRRK2 KO mice and a 4.66-fold increase of Wnt signaling activity in male LRRK2 G2019S KI mice with both effects being highly significant ( P < 0.0001; Fig. 2 B).

A mixed model with pulse shape (Rec, rampUP, rampDOWN, rampLONG) and polarity (anodic or cathodic-first) as fixed factors and mouse as a random factor showed a highly significant effect of pulse shape (n = 12, P < 0.0001) and of polarity (P = 0.0011) on the threshold.

We found individuals spent a lower percentage of their time being active during the non-breeding season than in the breeding season, this was statistically highly significant when activity was measured using activity sensors on the tag (F 1,42 = 193.66, p < 0.0001, Fig. 4 ) and when measured using the change of locations (F 1,42 = 232.41, p < 0.0001, Fig.

Figure 4 shows a bar graph of the average A , ε m a x , ε ∞ , τ r of the 4 cell lines and indicates the level of significance: where p > 0.05 is not significant (ns), 0.01 < p < 0.05 is significant (*), 0.001 < p < 0.01 is very significant (**), 0.0001 < p < 0.001 is extremely significant (***) and p < 0.0001 is extremely significant (****), raw values can be found in Table S1 .

A highly significant interaction between geometry and CCF inclusion was also identified ( p < 0.0001), demonstrating that the influence of fibre reinforcement on void formation differs according to geometric complexity.

able 4 : the coefficient of determination R 2 of the model is 0.9742, meaning the model can explain 97.42% of the adsorption rate variation, which is much higher than the fitting requirement of general regression models (usually R 2 ≥0.95 is considered excellent fitting); the synergistic results of extremely significant model P-value < 0.0001 and non-significant lack-of-fit term P = 0.4314 > 0.05 not only confirm that the model equation has extremely high statistical reliability within the experimental range, but also indicate that the model does not miss key influencing factors, which can effectively avoid the in

We also observed a highly significant ( P < 0.0001) co-expression of IGF-IRa1 and IGF-IRa2 ( Fig. 4B,D ), as observed in different tissues.

The shorter survival time of animals with Ahr -deficient GCPs was highly significant (p < 0.0001, log-rank test).

The results revealed a highly significant positive correlation between chronotype assessed by both parameters (n = 3240; Pearson correlation coefficient r = 0.327; P < 0.0001) (Fig. 1a ), confirming relevance of data and methodology used to assess chronotype in this study.