Excerpts

The differences between the values from the 3T3BXB-ER cells as well as the differences between 3T3 and 3T3BXB-ER cells were highly significant (p≤0.001), resulting in a decreased nuclear volume by ∼40% in estrogen treated BXB-ER cells.

The entire model had an adjusted R 2 of 0.79; 0.64 of the variance was explained by the first axis, and 0.14 of the variance was explained by the second axis, with both of these values highly significant (p<0.001, 999 permutations).

Patients with high ULK1 expression also displayed a significant trend toward worse survival compared with patients with low ULK1 expression (HR = 4.206, 95%CI (2.875–6.153) P<0.001, Table 2 ).

The paired t-test yielded highly significant differences (p<0.001) between the bite durations of strong (0.68 s ± 0.26 s) and weaker bites (0.45 s ± 0.11 s).

The CCLAD unadjusted RR is not significant with a high p-value (0.996), upon adjustment this turns highly significant (p<0.001) which is not impossible but rather unusual.

We also compared patient-derived MSRS composite scores with physician-derived clinical scales; while the correlations were weaker, these remained highly significant (p<0.001): EDSS (r s = 0.609), T25FW (r s = 0.497), and AI (r s = 0.591).

Again, all three main effects turned out clearly significant, confirming the pattern from the individual experiments (all F > 31.33, all p < .001).

In patients, who had adjuvant therapy (n = 5) the increase in ADC values between pre- and post-EBRT did not reach statistical significance using two of the measurement methods (L-ROI mean , P = 0.084; S-ROI min, P = 0.105), while in patients with no adjuvant therapy (n = 47) the increase was highly significant with all ROI measurement methods ( P = 0.001) ( Table 3 ).

A highly significant main effect of Time (F(1, 90) = 26.532, p < .001, ŋ p 2 = .371) showed a significant reduction in children’s acute cortisol after interventions.

Heatmaps were constructed to enable visualization of data for the top 25 highly significant compounds that had large changes in abundance in dogs with sepsis at the lowest P-values <0.001 ( Fig 2C ).

Severe fire had a highly significant (P<0.001) effect on tree death ( Supplementary Information S2 ).

One-way ANOVA revealed highly significant differences in mean finish time among pacing patterns ( F 3,78908 = 8012.1, p < 0.001, η 2 = 0.233 ).

Analysis of variance revealed a highly significant effect (p < 0.001) of metals treatments on the weight of depleted seed reserves (SRW) during germination.

Non-MHC loci had only a few signatures of interactions with marginal significance (smallest p ~ 1×10 −3 ) between CTLA4 , HLA-DR , HLA-DQ , IL2RA , and INS loci ( S1 Table ).

Before the pandemic, there was a small trend of increased prescribing (incidence rate ratio [IRR] per period 1.002; 95% confidence interval [95CI] 1.001–1.002; p<0.001), with a change in level (immediate increase) at the pandemic date (relative increase in IRR 1.674; 95CI 1.206–2.322; p = 0.002).

Consistently, there was an extremely significant increase in HbA1c% on comparing both T2DM+ATHR and T2DM-ATHR diabetic groups to the control group (P<0.001 and P<0.01 respectively).

The post-hoc test revealed that the reaction time for highly significant words ( M = 816.39, SEM = 29.95) was significantly shorter than for both low significant words ( M = 835.69, SEM = 32.08; t (34) = -3.976, p < .001, d = 1.36) and for medium significant words ( M = 825.91, SEM = 30.68; t (34) = -2.42, p = .04, d = 0.83).

The mean BMI at presentation showed an increasing trend over time; the linear regression association was statistically significant among type 1 DM ( P <0.001) ( Table 1 , figure 1 ).

Validation of speckle tracking echography The correlation between echocardiographic and sonomicrometric pooled measurements was highly significant (R 2 = 0.98, P <0.001) with a slope close to 1 ( Fig 3 ).

Specifically, the relationships between the two smallest size classes (50–75 μm and 75–100 μm) of zooplankton and the larval fish density were highly significant ( p < 0.001 and p = 0.001; Fig 3A and 3B , S3 Table ).

2C shows a moderate but highly significant constitutive IFN-β expression and IRF-3 activity -but no NF-κB activity (not shown)- in WT RIG-I-transfected cells (n = 3, p <0.001 when compared to control vector-expressing cells), in agreement with the fact that RIG-I is especially prominent in signaling pathways leading to type I IFNs [2] , [3] , [4] , [15] .

Early Hibernation During early hibernation the effect of age/sex class on BCI was highly significant (F 3,121 = 27.1, p<0.001; Figure 2 ).

Radial strain and circumferential strain were significantly reduced in both mild- to-moderate and severe OSA compared to control and reached a highly significant level in patients with severe OSA (p < .001).

All differences were highly significant (paired-samples Student’s t test p <0.001).

Only the regression coefficients for nitrogen were highly significant (β = 1.20; t = 4.83; P<0.001).