Barely Significant

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Intake of animal food sources such as “meat and poultry”, “eggs”, “fish and shellfish”, and “milk and dairy products” increased significantly before adjusting for gender, age, and energy intake (unadjusted p -value for trend <0.001, “milk and dairy products” were not significant before adjusting.), and showed a decreasing trend after adjustment for gender, age, and energy intake (adjusted p -value for trend <0.01).
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Multivariate analysis showed that, with the exception for sperm volume, highly significant differences in sperm parameters were observed across the three categories of adherence to MD, with increasing mean values of sperm concentration, total sperm count, progressive motility, sperm viability, and the percentage of sperm with typical morphology along with the adherence to MD (all p -values < 0.001, Figure 1 A).
Although no main effect was found for the product factor, the presence of an almost significant interaction between product and match week, combined with the descriptively progressive increase observed in the NIT + CM group, may point to a more favorable adjustment in this group over time.
In contrast, the case–cohort European Prospective Investigation into Cancer and Nutrition (EPIC)—InterAct study (a multi-center, prospective, cohort study of 519,978 participants from 8 European countries aimed at investigating the relationship of environmental factors, food habits and lifestyle with cancer and other chronic diseases), including 12,403 incident T2D cases and a random subcohort of 16,835 subjects, did not reveal significant effect modifications of TCF7L2 variants in the association between cereal fiber and T2D, except for a borderline significant protective association among carriers of TCF7L2 rs12255372 GG [ 145 ].