Excerpts

Table 2 provides a list of the strongest associations identified across the entire data set, all highly significant (Bonferroni-corrected P <0.05).

First, to validate the reproducibility of highly significant gRNA–gene associations (Bonferroni P ≤ 0.05 in each screen), we performed the same inference on the small-scale screen.

Although nest site showed a significantly positive Mantel correlation ( P < 0.01), the positive correlation showed no or only marginally significant differences from neutral model simulations ( P = 0.05; Fig. 3b ; Supplementary Table 1 ).

In stage 2, we examined the 28 lead SNPs from stage 1 in the Asian-specific meta-analysis ( n = 8107) and found that 16, including the novel lead SNPs within or close to ADAMTS8 and DCN , were significant after Bonferroni correction ( P ≤ 1.79 × 10 −3 , 0.05/28), further three other SNPs including the two novel close to STAG1 and NDUFAF6 were nominally significant ( P < 0.05).

On the other hand, among the 986 SNPs with estimated PPR >99%, 47% were nominally significant with p < 0.05 in the replication cohort 23andMe, and 79% with consistent direction of effects.

We then determined the time series of β SOT using 15-year moving windows from 1982 to 2021 at each pixel and found that 38.6% of regions exhibited a significant increase in β SOT for kNDVI, while 22.0% showed a decreasing trend ( p < 0.05) (Fig. 1A ).

PyC did show an increasing trend with warming under eCO 2 (Fig. 1c ; p > 0.05) probably due to previous biomass burning and incorporation of residues before the SPRUCE experiment 49 .

We applied conditional analysis to all pairwise combinations of nominally significant ( P < 0.05) cell types within a given tissue to identify cell types whose trait association signals are independent of the other significant cell type 44 .

In total, we identified 31,162 nominally significant ( P value < 0.05, |r | >0.05) correlations between open chromatin and gene expression.

The overall firing rate correlations with trial outcomes increased after outcome onset and was stronger in the Guanfacine than vehicle condition in dlPFC, striatum and with a statistical trend in the ACC (Fig. 3A ; permutation test, dlPFC: p < 0.05 during 0.5–0.6s; striatum: p < 0.05 during 0.05–0.3s; ACC: p < 0.075 during 0.4–0.45s).

We retained for downstream analyses all loci with nominally significant binomial p values ( p < 0.05) and at least 2 reads (10%) mapped to any allele.

coli lysates expressing IsmA and SpiR revealed that SpiR generated a higher cholestenone signal, with a marginally significant difference ( U = 9.0, p = 0.05, Mann–Whitney U test).

Of these 86 variants, 67 replicate at the nominally significant threshold ( p < 0.05) in the current GWAS of MVP-CBP, and 54 replicate at the Bonferroni-corrected threshold (Supplementary Data 12 .

While none passed multiple testing correction, mainly because of a lack of power since we have a limited sample size in an analysis with thousands of parameters (clones), we could observe that the few clones that approached significance ( P -value < 0.05) were shared across patients only in PR group and enriched at 24 months post transplant.

We provided detailed RegulomeDB annotations in relevant cell types (e.g., hematopoietic multipotent progenitor cells, CD34+ hematopoietic progenitor cells, any primary B-cell, lymphoblastoid cell lines from 1000 Genomes [i.e., GM19238], K562, NAMALWA, BLaER1) for: (a) all index variants; and (b) credible set variants with nominally significant ( P < 0.05) functional probability scores.

In total, 115/130 GEIs were nominally significant ( p < 0.05) and directionally concordant with estimates from the replication set (Supplementary Data 13 ).

Our combined analysis across all race/ethnic-groups identified 32, 30, 75 and 55 nominally significant signals (at P < 0.05) out of 104, 122, 181 and 156 variants examined in association with FEV1, FVC, FEV1/FVC ratio, and COPD, respectively (Supplementary Data 3 ).

According to BADGERS, the reference panel comprises 1738 traits from the UKB 17 , selected on the basis of nominally significant SNP-based heritability ( P < 0.05).

Of the 174 lead SNPs identified in the discovery cohort, 145 (83.3%) remained nominally significant ( P < 0.05) in this replication dataset.

Only the volumes of the caudate, corpus callosum and third ventricle achieved a heritability that was nominally significant in our sample (uncorrected P <0.05).

Notably, 11 loci exhibited nominally significant ( P < 0.05) association with IGCTs: CLPTM1L , PITX1 , SPRY4 , TNXB , two loci of BAK1 , KATNA1 , DEPTOR , GAB2-NARS2 , HNF1B , and TKTL2 (Fig. 4 ; Supplementary Data 1 ).

T/F viruses with incompletely closed Envs were also more sensitive to sCD4, although this difference did not reach statistical significance ( P = 0.05; Supplementary Fig. 3d ); and we observed a significant correlation between cold and sCD4 sensitivity ( P = 0.0005; Fig. 1f ).

While only variants with P < 5 × 10 −8 were considered significant, to also identify suggestive variants for supplementary results, in each clump, index SNPs had a suggestive association based on P < 1×10 −6 , and SNPs were added if they were marginally significant with P < 0.05, were within 500 kb of the index SNP, and had r 2 > 0.1 with the index SNP.

A linear mixed effects model fitted to stimulus value ratings (i.e., how much participants wanted to eat the food items) found a main effect of group ( ß = 0.10, SE = 0.03, p = 0.003, 95% CI [0.03–0.16]), controlled for BMI, which had a borderline significant effect on stimulus value ratings ( ß = 0.01, SE = 0.006 p = 0.05, 95% CI [−0.0002 to 0.02]).

About 74.2% of the land surface shows an increasing trend, among which 52.7% is significant at p = 0.05 level (two-tailed).