Excerpts

This difference is highly significant, with t -test p = 0.007 ( n = 4); the signal change observed with the control injection probably arises from mild edema due to the introduction of fluid.

The RMSD value of 0.237 was highly significant (permutation test p-value ≤ 0.0072), confirming that identical genomic sequences folded into very similar local structures despite the very different context.

Correlations between qPCR- and 16S-ASV-based MOB community proportion and CH 4 uptake were highly significant ( p < 0.008).

Despite low cDNA concentrations and low expression of the alternative TSS, we observed an overall trend in AEI in accordance with our reporter assay and cell models (median AEI = 1.06, Mann–Whitney U-test on 9 DNA ratios vs. 9 RNA ratios, p = 0.008).

Among the T cells, CD4 + (42% vs 50%, p = 0.0237) and CD8 + (25% vs 30%, p = 0.09) T cells showed a trend towards increase, while double negative (CD4-CD8-) T cells (35% vs 22%, p = 0.0082) were significantly reduced in the treatment group (Fig. 6f ). 6TdG treatment resulted in significantly reduced expression of checkpoint receptors, PD-1 and Tim3, on CD8 + T cells (PD-1: 8.2% vs 3.5%, p = 0.0097; Tim3: 6.7% vs 3.2%, p = 0.0097) (Fig. 6f ).

The epithelial MCT1 and stromal MCT4 showed a trend that was negative with all the HP 13 C-MRI metabolic parameters, with a significant negative correlation observed between stromal MCT4 and k PL ( P = 0.009; Fig. 2b , Supplementary Table 3 ).

We also assessed eight pancreatic cancer risk loci identified in Chinese and Japanese individuals in our data and noted one nominally significant locus in the combined PanScan and PanC4 results (6p25.3, rs9502893, OR = 0.94, 95% CI 0.92–0.97, P = 0.009: Wald test; Supplementary Table 6 ).

When the Marine West Coast Forest ecoregion was excluded, a strong, moderately significant correlation was present between the drainage network density (total stream + river length:total area) and the SL BA :burned area ratio ( R 2 adj = 0.66, p = 0.0091, n = 8, Supplementary Fig. 1 ).

A similar situation was encountered in APOE , where one STR (chr19:44910674) showed a change in P value from merely nominally significant ( P = 9.33E−03) to genome-wide significant ( P = 4.67E−23) (Supplementary Data 10 ) after conditioning on rs429358 (“e4-allele” in APOE ).

Interestingly, there is no correlation between RPKM FP and Kozak context (Pearson r = 0.03716, p = 0.3627), whereas Kozak context has a small but quite significant correlation with framing (Pearson r = 0.1054 p = 0.0096**).

Values are denoted as significant (p <0.05) or highly significant ( p < 0.01).

Based on the obtained results, the data was considered not significant (P≥0.05), significant * (P≤0.05), highly significant ** (P≤0.01), or very highly significant *** (P≤0.001).

89 ZED88082A in tumor lesions from pre-CART to post-CART Among the 21 evaluable patients, 89 ZED88082A tumor uptake first declined from a geometric mean SUV peak of 4.0 (95%CI [3.3–4.8]) pre-CART to 2.4 (95%CI [1.8–3.3]) post-CART day +5, whereafter an increasing trend to 3.6 (95%CI [2.8–4.7]) post-CART day +7 was observed ( P < 0.01; Fig. 4a , Supplementary Fig. 6a ).

Of interest, the variation in read counts between INTS11-KD and control was barely significant over termination sites ( Fig. 4d ; Supplementary Fig. 7d ; P ~1e−2; right box plot).

Importantly, statistical significance or a trend toward significance was retained at other cut-points as well, including 1, 10 and 20% (PFS log-rank P =0.01, P =0.08 and P =0.03, respectively, and OS log-rank P =0.002, P =0.01 and P =0.11, respectively; Supplementary Fig. 3 ).

Analysis of similarity (ANOSIM) between groups of nearby seas found highly significant differences (R statistic 0.561, and no pairs of groups approached this value, P < 0.01), thus re-affirming that the groups represented biogeographically distinct realms.

Direct comparison of VIP ChR2::EYFP and VPAC2 ChR2::EYFP PRCs therefore revealed highly significant time effects and interaction between time and cell-type (both p < 0.01) (Fig. 5f ).

In the three CRC groups, the levels of these five urinary proteins showed a gradient with an increasing trend that correlated with disease progression, achieving the highest levels in DM ( P < 0.01 for all; Fig. 4a ).

To filter these TF- coexpression modules, each was subjected to a cis-regulatory motif analysis using RcisTarget (SCENIC) and only modules with a highly significant motif enrichment ( P < 0.01) were retained for further analysis and pruned of indirect targets lacking motif enrichment.

In addition, for FI, the analyses showed multiple significant enrichment peaks in blood in men, whereas those in women were only nominally significant ( P = 0.01) (Supplementary Fig. 3a ).

The nominally significant association signal at this lead variant (rs11934731, effect size for the minor allele = 0.029 SD, P -value = 0.01, MAF = 33%) was slightly attenuated when we performed conditional analysis with MEPE p.Lys70IlefsTer26 as a covariate in the model (effect size conditional = 0.021 SD, P -value conditional = 0.06; Supplementary Fig. 1 , Supplementary Data 1 ).

The correction was done in two steps: first, we regressed the expression vector of each gene against covariates and selected those with nominally significant coefficients ( p < 0.01).

S1e ) together with a strong trend toward reduced vS1 selectivity during the stimulus period ( P < 0.01, n = 21 and 31 sessions for control and APP-KI mice, respectively, one-tailed bootstrap without a multiple-comparison correction method, Fig. 1e ).

Genes or splicing events that are nominally significant at p < 0.01 for SNP heritability ( cis - h g 2 ) are used for training predictive models (Supplementary Figure 3 ).

Statistical comparison by analysis of variance was performed at a significance level of p < 0.05 (* represented) and a highly significant level p < 0.01 (** represented) based on a Student’s t -test.