Excerpts

In the present study, we found an overall trend of relaxed selection amongst human-infecting compared to bird-infecting trichomonad species, suggesting higher levels of genetic drift as a factor in their genome expansion.

6c ), demonstrating a pronounced trend towards lower scores for ZF targets, suggesting fewer unfavorable interactions (Supplementary Fig. 4 , 5 ).

We also observe an increasing trend in the Brillouin shift of the aggregating region over time, suggesting an increased stiffness.

While none of the 1463 Reactome pathways were significantly enriched for DC differential expression (corrected p -value at 0.05), two pathways were significantly enriched for AC (Platelet sensitization by LDL and Response to metal ions), three for TI (Cytoprotection by HMOX1, Haem signalling and Response to metal ions), and one was significant for R (Aflatoxin activation and detoxification), and four narrowly missed statistical significance, including two interferon signalling pathways—gamma and alpha/beta (corrected p -value at 0.059, Supplementary Fig. 7B ).

This may be significant as IL1-β -mediated inflammation appears critical in accumulation of basaloid intermediates (or damage-associated transient progenitors, DATP) in murine models of alveolar injury 10 .

Thus, despite highly significant and strong correlation in abundance between ABIs and the immune cells, CD103 + CD4 T cells and neutrophils at the leading edge of disease (Intm stage) (Fig. 2l, m ), neither cell types were spatially associated with ABIs in this disease stage. g ( r ) plot for CD206 hi macrophages - ABI_b-DC ADJ pairs showed the same qualitative distribution across the three disease stages (Fig. 3c )—the peak in co-location (‘g_max’) for CD206 hi macrophages-ABI_b-DC ADJ cell pair was found near the centroid of ABI_b-DCs, indicating stronger co-location above CSR nearer to ABI.

coli genome showed a highly significant increasing trend over time, similar to that of swine and human E. coli (Fig. 3c, d ).

Similarly, the loss of caspase-8 exacerbated cell death and showed a trend toward impaired BBB integrity (Supplementary Fig.

As expected, the wound closure rate of diabetic rats was significantly delayed compared with non-diabetics; Gal-3 significantly promoted wound healing 3 days and 9 days after application, which was comparable to that of non-diabetic rats and Comfeel® dressing; VEGF showed a strong trend of accelerated skin wound healing, albeit without statistical significance (Supplementary Fig. 6F ).

mRNA expression of the re-epithelialization marker Cdh1 (encoding E-cadherin) was significantly upregulated, whereas mesenchymalization marker Cdh2 (encoding N-cadherin) showed a trend toward reduction (Supplementary Fig. 1H ).

Therefore, the nominally significant results should be interpreted with caution and need to be validated in our planned new phase 2/3 trial.

It is worth noting that an increasing trend of small LiF precipitates is observed at higher F dopant concentrations, as shown in Supplementary Fig. 7 .

22 , the two emission peaks of X-CPDs -3 show a decreasing trend with the temperature increasing from 78 to 358 K, indicating the delayed emission peaks both belong to RTP.

When examining the reason for this low specificity, we found an inherent weakness with these approaches: if a gene was highly significant in a small minority of datasets it would often pass significance thresholds after meta-analysis, even if no signal was observed in the remainder of the studies.

As we have shown here, this accumulation of cortical components has quite significant effects on the same signaling nodes that are also controlled by chemical stimuli.

IL-1β also showed an increasing trend, although it was not statistically significant (Fig. 5B ).

During the LGI, the particle flux increased at CDH19, was in an increasing trend but did not reach its maximum at V30-99, and did not increase at U1313 (Supplementary Fig. 6 ).

During the span of MIS 5e, all three Pa/Th records show a decreasing trend starting from an already low Pa/Th, likely indicating a continued AMOC strengthening after the recovery from Heinrich event 11.

The former may be significant due to the tendency of the perovskite surface to adopt lead iodide as the terminal, accompanied by a substantial number of halogen vacancies and undercoordinated lead ions.

The velocity vectors pointed to directions consistent with an increasing trend of the percentage of viral RNAs in individual cells, which inherently served as an indicator of the infection time course 40 .

Repetitive terms were deleted, and some terms related to cell fate decision with highly significant p values were selectively shown in all GO analyses.

Values with P < 0.05, 0.01, 0.001, or 0.0001 were considered statistically significant (*), highly significant (**), very high significance (***), or extremely high significance (****), respectively; n.s. represents no significance.

The number of mitochondrial cristae in MC3T3-E1 cells in the ADI group was clearly significantly reduced, and even mitochondrial fragmentation occurred, which was slightly rescued in the CZ or CZ@LC groups, whereas the number of mitochondrial cristae (yellow arrow) was rescued in the CZP or CZP@LC groups due to robust inhibition of lipid synthesis (Fig. 8I ).

While an overall trend of increasing median elevation with proximity to volcanoes is present for all search radii, the stronger signal is found within the first 5 km.

Although these associations were highly significant, and inclusion of occupancy change increased the explained variation in naturalization success (Table S24 ), the standardized effect estimates were always smaller for the occupancy-change index than for occupancy in the early period (Tables S12 - S21 ).