Excerpts

We observe an increasing trend in risk scores from healthy controls to non-invasive groups and finally to invasive groups, suggesting that the SMART platform may be applicable in pre-screening scenarios.

However, with the widest prior ranges (60 and 80), the relative risk estimates associated with NA and HA stalk were less precise, with credible intervals overlapping 1, suggesting borderline significance.

When the mean incubation period increased from 1 to 2 days, some borderline significant parameters—such as the effect of HA stalk on susceptibility and NA on infectivity—shifted slightly above 1 in the upper value of the 95% credible intervals.

In line with knock-down by siRNA, treatment with the calcium channel blocker drug nicardipine 55 or AOX1 inhibitor drug raloxifene 56 also showed a trend towards increased HDR when combined with M3814 (Fig. 3h ).

Podocalyxin, a negatively charged sialylated glycoprotein involved in polarization 17 and basal organization 18 , exhibited stable protein expression and an increasing trend in the HF group (Fig. 3c, d , Supplementary Fig. 3a ).

Lastly, we emphasize that not all lectins followed the simple rule of preferring higher surface-availability, as lectins such as PHA-L actually showed a trend of preferring their binding motif to be somewhat buried (Supplementary Fig. 10e and f ), potentially indicating additional interactions with distal sequence contexts.

5g ), resulting in a nonsignificant trend towards greater nearest neighbor distances in synapses with ongoing fusion.

However, transcriptomic investigations have consistently identified approximately the same number of genes being up- or down-regulated during seedling or cotyledon de-etiolation, and none have demonstrated a clear trend in gene upregulation 8 – 11 .

While TMX NPs showed a trend of improvement over the free drug (Supplementary Fig. 13B ), the p -value did not reach statistical significance.

1 A shows that the total adoption rate in Washington is around 1.9% in 2022, and the incremental adoption rate presents an increasing trend from 2010 to 2022.

Since the associations at this locus were highly significant, we looked for variants that might affect protein structure and function.

Other inflammatory genes such as Tnf, Il6, Il10, Cxcl2 and Ifnb also showed a trend towards higher expression levels in the lungs of RPC mice at this time point.

We found that the PNS group showed a trend toward lower incidence rates of HAEC and total complications across all subgroups.

Sedimentary archives from the ECS reveal a striking divergence: while δ 13 C org exhibits an increasing trend, 10 of 13 cores show coherent declines in δ 15 N from the early 1900s to present, with an average rate of −1.09 ± 0.48‰ per century (Supplementary Figs. 8 and 9a–b ).

Conversely, a weak trend between MW and toxicity suggests that heavier compounds are less toxic.

A statistical trend for an association with mood was further detected for the AAA ( t = 2.6, p uncorrected = 0.011, p corrected = 0.061, subpart 9, light green on Fig. 2A ) and the intercalated nuclei ( t = 2.46, p uncorrected = 0.016, p corrected = 0.089, subpart 10, green on Fig. 2A ) (Fig. 2L, M , Supplementary Table S4.d ).

Accordingly, we subdivided the compiled Ordovician Δ 199 Hg profile into four intervals, including (1) a decreasing trend of Δ 199 Hg values during the early Tremadocian to middle Floian (~485-473 Ma), (2) a dominance of near-zero Δ 199 Hg values during the late Floian, followed by a decreasing trend from positive to near-zero values during the earliest to early Dapingian (i.e., the LFCE) (~473-468 Ma), (3) a gradual

7 ) shows a decreasing trend in work function (WF) across the support materials: CeO 2 (5.79 eV), CNTs (4.91 eV), and CeO 2-x /CNTs (4.71 eV).

As satellite retrievals and reanalysis products indicate a positive trend in Q v near the surface over the last four decades 41 , the connection between water vapor and σ W explains some of the positive trends depicted in Fig. 1 .

However, the D208N mutant showed a clear trend towards hexamer formation even before incubation, with the hexamer fraction becoming dominant at equilibrium (Fig. 2f , middle).

Although the difference was not statistically significant, a clear trend towards an increased expression pattern was observed in the CIP group compared with the CTL group (Supplementary Fig. 3d , e ).

The numbers of CD69 + tissue resident memory T cells (Trm) did not change significantly, but showed a trend towards an increase when co-cultured with SGE-stimulated moLCs similar to what we previously observed in an experimental tick bite model 5 .

We observed elevated criterion (i.e., shift toward a conservative stance) in both VA and VP sonication compared to baseline and to dorsal targets (DA and DP), although many of these pairwise comparisons reached only marginal significance after FDR correction (Fig. 3c ; VA vs.

The increase in median intrinsic noise when animals receive met-2(cat) from the female germline was highly significant, shown in Fig. 6e, f .

Systematic optimization across a temperature range of 800–1300 °C revealed a clear trend in phase evolution.