Excerpts

Cox regression analysis of WHO grade IV (GBM) patients divided into BRCA1 low (<14.5%) and BRCA1 high (>14.5%) or RRM2 negative and positive groups showed a trend toward worse survival of BRCA1 high and RRM2 positive patients (251 days for BRCA1 low versus 159 days for BRCA1 high and 320 days for RRM2 negat. versus 148 for RRM2 posit.; Fig. 6d,g , respectively).

And there is a clear trend that both E g and A 1g peak frequencies move to the higher wavenumber region, when the thickness of sheets decreases.

Nevertheless, the circulating insulin levels in diabetic IL-1r −/− were significantly decreased compared with non-diabetic counterparts, while a strong trend towards decreased levels was found in diabetic Tlr2 −/− and Casp1 −/− mice, even though it was not statically different.

Oxygen alone had a highly significant negative effect on the production of N 2 O ( Fig. 4a , Supplementary Table 3 : M7 versus M6).

However, this is only an overall trend; the scatter is obvious even when the G values are plotted on a logarithmic scale ( Supplementary Fig. 2 ).

Although highly significant from the perspective of confirming the analytic theory of breathers 31 , these experiments do not, however, model the scenario of the ‘spontaneous' MI where breather-like rogue waves emerge from low-amplitude broadband noise.

Unlike tumours, the gold content of 5NP-1Tz in liver and spleen decreased after 24 h, while an increasing trend over time was observed for 5NP-2Tz up to 96 h.

All four sites were sampled across a wide range of elevations from valleys to summits and show an overall trend of increasing simple exposure 10 Be age with altitude ( Fig. 2a ).

FN-EDB expression has been documented in several tumour types, including HNSCC 13 , 14 for which multivariate analysis showed a trend towards significant lower overall survival (OS) 15 .

Analysis of the average local treponemal burden revealed a slight trend towards increased T. pallidum DNA concentrations ( flaA copies per μg host tissue DNA) at the primary lesion sites of the three immunized animals compared with the two control unimmunized animals ( Fig. 3a ).

The transgenic mice also showed a trend towards improved glucose tolerance ( Fig. 9b ).

However, an examination of the electronic manifolds of 3Ce , 3U and 3Th reveals a common molecular orbital that may be significant.

In the resulting difference map, exactly one highly localized and highly significant (>7 σ ) density reduction was observed for the TRAPδ-deficient translocon, defining the position of the TRAPδ subunit in the TRAP complex ( Fig. 2c ).

However, a positive trend during this period may result from pre-industrial era anthropogenic activities 1 .

This suggests that feathering—particularly its symmetry, size differentiation and spatial arrangement—was highly significant towards how some basal paravians utilized their arm (and likely leg and tail) function for aerodynamic benefit.

Likewise cells expressing IGF1R/IR showed a strong trend toward increase in IGF-1-induced glycolysis rate (1.6-fold) and maximal glycolytic capacity (1.5-fold) compared to cells expressing IGF1R ( Fig. 1f,g ).

From each region we chose two or more SNPs for replication: the most significant SNP plus one or more additional SNPs and, where available, highly significant exonic variants.

The acute hazard quotient has remained relatively steady in spring wheat, although a decreasing trend is apparent since 1998 ( Fig. 4 ).

The CMIP5 multi-model ensemble mean forced response in HT BSO does show a positive trend (∼8 TW per 37 years, Fig. 4 ).

11 , reveals an increasing trend, indicating that bias-modulated performance of the device was not responsible for the obtained signals.

Importantly, there was a highly significant and specific overlap between the predicted targets of miR-132-3p and the genes downregulated with age ( Supplementary Data 2 , 181 genes, odds ratio 2.10; Fisher exact test P <0.0001).

Our present study indicates a clear trend of such a transition; further enhancement of the interlayer coupling is needed to materialize such a topological phase transition.

Discussion Genetic and pathogenetic analyses have confirmed a highly significant and direct role for LOXL1 in the pathophysiology of PEX syndrome and its associated ocular and systemic complications.

WT CHCHD10 transfected cells showed a nonsignificant trend toward increased mitochondrial length compared to vector control transfected cells both at basal and carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone (FCCP) conditions ( Fig. 3i–k ).

No significant heterogeneity was observed between the study groups and the three singe-nucleotide polymorphisms (SNPs) are nominally significant in the Danish follow-up.