Excerpts

P -values below 0.01 were considered significant, whereas P -values between 0.01 and 0.1 were considered borderline significant.

Consistently, when patients from each cohort were divided into three clusters based on the hierarchical relationship, we found a significant trend linking interaction networks to the overall survival of patients, further indicating that the interaction network is a stable feature of HCC aggressiveness (Supplementary Fig. 15b ).

The results demonstrated that the total amounts of inflammatory cells in BALF of Il-10 −/− mice showed a trend toward increase compared to the levels in BALF from WT mice, though the differences were not statistically significant (Supplementary Fig. 12a ).

The slope coefficients from this log–log regression (power exponent b ) were extracted from the model and regressed against year (as a linear term) to determine whether the effects of richness on the RY showed a trend over the 17-year period.

Given that the read for species Clostridium sporogenes was not detected, we analyzed the levels of genus and identified a notable trend of lower levels of Clostridium sensu stricto in pCR patients compared with those in non-pCR patients albeit that the P value was calculated as 0.07 (Supplementary Fig. 9d ).

Meanwhile, Δ T continues to fall (as SAT rises), resulting in a negative trend in the ice production attributable to the Sep open water setting.

While in our linear model for CESM-LE F w is an insignificant term in the Kara-Laptev region, it may be significant in other areas of the polar oceans (and perhaps in other models in the same region), and could be included as an additional regressor.

At the individual level, we observed a decreasing trend in the abundances of Staphylococcus and Corynebacterium from the skin to GI tract (Supplementary Fig. 2B ).

In repeated trials, the difference between PKD organoids and isogenic controls was quantifiable and highly significant (Fig. 1a ).

Last but not least, it is extraordinarily significant to further improve the resolution of the testing instrument and the stability of the testing environment to ensure that the error caused by the testing process is minimized.

33 who documented an increasing trend of SSH in the eastern Nordic Seas from 1993 to 2017, dominated by the heat content change from the inflowing AW water.

An interesting trend in recent current sheet statistics in both the near-Sun and near-Earth solar wind 45 , 46 is that, the thinner the current sheet is, (i) the stronger its peak current normalized by the Alfvén current J A = n 0 e v A , (ii) the smaller the current sheet amplitude (amount of magnetic shear relative to the average global magnetic field strength), and (iii) the smaller the shear angle.

2d, e ) showed a trend towards reduced EpCAM+ tumor cell content, and a 2.5-fold reduction in EpCAM+MSI2+ cancer stem cells at midpoint (7–8 weeks) (Fig. 2b , Supplementary Fig. 2f ).

Notably, we observed robust and highly significant correlations between potencies in the HTR assay and in vitro 5-HT 2A R potency measures, including binding affinities ( K i ) measured using [ 3 H]-ketanserin, and functional potencies (EC 50 ) for activating Gq and β-arrestin2 via 5-HT 2A R (Supplementary Fig. 10B-F ).

A sensitivity analysis was performed on the main association hits, and assessed whether highly significant P values were robust to models that included 0, 2, 5 or 10 PCs.

An increasing trend of mitochondrial content in MM, EMM1, and EMM2/1 organoids (fold change of 1.73 ± 0.10, 2.60 ± 0.11, and 3.10 ± 0.18, respectively) was quantified relative to control, suggesting that developmentally maturated organoids had an increasingly higher capacity for aerobic respiration and responded positively to maturation stimuli (Fig. 4b ).

To identify such spatially patterned genes, we applied MERINGUE 8 to identify 457 genes with highly significant spatial autocorrelation (Methods).

In the kidney, TMV had a clear trend of higher expression of HAS2, although it was not significant due to large variation (Supplementary Fig.

In comparison, the monophasic Ni(OH) 2 /NF experiences an increasing trend with current density.

Liver site showed a trend in restoring normoglycemia similar to the kidney capsule, even using eight times fewer NPIs, confirming the concept that the timing of β cell function after implantation is mainly dependent on the generation of vascular connection and partially independent of the implanted mass.

For SSN and MSN, the maximum plasma concentrations (C max ) were attained after 48 h of administration, and the plasma concentration showed a decreasing trend thereafter.

However, those three proteins may be significant in regulating OS protein transport through the CC.

By contrast, the absorbance curve A (405-490nm) of the thrombin-initiated system showed an increasing trend with decreasing cleavage rate ΔA/min, which only persisted for 20 min when at 10 –2 Unit μL −1 .

1c and d , respectively) responded in any significant manner to exposure to Xt3a, with the exception of a weak trend towards increased activity with 1 nM and 10 nM concentrations (Fig. 1c ).

Here, Brca1 Δ11/Δ11 cells that were MDC1 foci-positive post-thymidine release showed a trend for resolution during mitosis.