Barely Significant

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No significant difference, but a trend toward significance, was observed between groups regarding the number of responders at the end point (>50% decrease from the baseline), one month after the stimulation sessions (1/18 in the sham group versus 6/21 in the active group; p = 0.098); there was only one responder in the active group at day 5 (the one also achieving remission criteria). 4.
In a critical patient, there could be a similar pathophysiological behavior within the first days of admission; there may be significant hemodilution due to the alteration of the hydric compartments after an initial intensive fluid therapy, where a plasma Hb has decreased but the total Hb mass has not been altered, with differences greater than 2 g per 100 mL being found between a measurement and the corrected one (carbon monoxide test) [ 5 , 6 , 7 ].