Barely Significant

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In Table 2 , we reported the results of cardiac and inflammatory markers in the four groups: we did not find any significant differences (including in routine blood biochemistry, data not shown) except for IL-6, which shows a significant trend for increasing levels from group A to D ( p for trend <0.05, by Jonckheere–Terpstra test, Table 2 ).
highly significantqualifiedgold
The authors analyzed de novo variants and observed a highly significant 3.5-fold enrichment of de novo protein truncating variants (PTVs), which are considered the most pathogenic variants, compared to a non-significant 1.2-fold enrichment of inherited protein truncating variants.