Barely Significant

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There was an incredibly significant increase of the weighted prevalence of retinopathy was noted on the category of A1C 48–49 mmol/mol (6.5–6.6%), when compared to the category of 45–46 mmol/mol (6.3–6.4%, 18.32% vs. 11.52%, respectively, p < 0.0001) and the category of 43–44 mmol/mol (6.1–6.2%, 18.32% vs. 13.05%, respectively, p < 0.0001).
Additionally, a recently published analysis of this study group stratified by the modified version of the Charlson Comorbidity Index (mCCI) shows a similar trend towards a worse outcome of patients with high mCCI under medical rhythm control, which just failed to reach statistical significance due to being underpowered [ 24 ].
In Table 2 , we reported the results of cardiac and inflammatory markers in the four groups: we did not find any significant differences (including in routine blood biochemistry, data not shown) except for IL-6, which shows a significant trend for increasing levels from group A to D ( p for trend <0.05, by Jonckheere–Terpstra test, Table 2 ).