Excerpts

Notably, there were no significant differences, either pre- or post-puberty, in leptin levels between the two groups of patients with overweightness/obesity (ASD+/Ob+ and ASD−/Ob+) or between the two groups with normal body weight (ASD+/Ob− and ASD−/Ob−) ( Figure 2 and Figure 3 ), although the comparison of non-ASD and ASD lean pre-pubertal children revealed a distinct trend toward significance ( p = 0.15, higher leptin levels in the ASD+/Ob− group than in the ASD−/Ob− group) ( Figure 2 ). 2.3.

Statistical significance was defined as a p -value of < 0.05, with a tendency toward significance defined as 0.05 ≤ p < 0.15.

Mocetinostat showed a decreasing trend in the level of STAT3 protein in LV of treated CHF compared to untreated CHF animals ( p = 0.15).

The expression level of precursor SREBP-1c protein was also lower, but showing only a tendency towards significance ( p = 0.15). 3.

For the R-ISS and cytogenetic risk scores, we found no significant difference between the tested groups ( p > 0.05), but there was a decreasing trend between Stages I and II ( p = 0.1547) ( Table 3 ).

Even though this showed a positive trend, no statistically significant association with the Poisson regression was found (IRR = 1.002; p = 0.157; dispersion = 0.46; p = 1.00).

Mannose binding protein ( Q98TA4 ) was also increased in abundance and approaching significance ( p = 0.16) on Day 35 in GHP1 samples ( Supplementary Table S1 ).

However, there was significant overlap between genes decreased by IDL + IDC and PIM ( p = 0.005, Figure S5D ), although the association was only marginally significant in some analyses ( p ≤ 0.16; Figure S5F,H .

24.5%) with a nonsignificant trend towards improved OS (HR 0.44, p = 0.16) [ 35 ].

Based on a systematic review and meta-analysis of randomized controlled trials, compared with standard therapy, the addition of SF showed a trend of decreasing 28-day mortality ( p = 0.17) only for the septic shock patients, with 4.5 mmol/L ≤ mean arterial lactate level < 7 mmol/L and with a yang-qi deficiency (a TCM syndrome) [ 72 ].

Among the responders, the AC heterozygous patients showed a trend towards a reverse association with a response to the therapy with TNF-α inhibitors (OR = 0.52, 95% CI 0.21–1.32, p = 0.17) whereas the CC homozygous cases showed a 12-fold reduced chance of responding to therapy compared with AA homozygotes (OR = 0.082, 95% CI 0.009–0.78, p = 0.029) ( Figure 1 ).

There was a nonsignificant trend toward less grade 3 or 4 neutropenia in the 48 h and 72 h fasting cohorts compared to the 24 h fasting cohort ( p = 0.17).

IMI group comparison ( p < 0.001), with a slight trend involving OS elevating FAAH expression ( p = 0.1720 for vehicle vs.

Patients with higher than median serum sCD163 levels showed a trend for more unfavorable overall survival ( p = 0.18, HR 1.4, 95% CI 16.7–43.2 for patients with values below median and 61.1–160.8 for patients with values above median).

Additionally, there was an increasing trend in the abundance of Lactobacillaceae ( p = 0.18) and Bifidobacteriaceae after L. reuteri DYNDL22M62 treatment.

Cases with and without a PDV are not significantly more or less likely to have an affected first-degree relative with a substantial NDD; although, there is a possible trend (+PDV 13/34 (38%) with a first-degree relative affected, no PDV 3/16 (19%), p = 0.18, odds ratio 2.7, 95% CI 0.6–11).

Females demonstrated weaker associations—ALT (β = −0.97, p = 0.031) and γ-GTP (β = −1.60, p = 0.015) reached marginal significance, while AST did not (β = −0.51, p = 0.181).

As shown in Supplementary Figure S5 , patients receiving tafamidis showed a trend toward improved outcomes for the combined endpoint and the endpoint death/htx ( p = 0.19).

Ca displayed a higher concentration in the STZ + HT group compared to the vehicle group (vehicle: 384.50 ± 15.00 mg/kg; STZ + HT: 1572.2 ± 386.29 mg/kg; p = 0.0493; Figure 6 A), whereas STZ group showed a trend without a statistic difference (STZ: 793.36 ± 286.68 mg/kg; p = 0.1909).

4.5 ± 2.0 p = 0.026); other factors showing an association at the level of a statistical trend were low BW ( p = 0.191) and the coexistence of IVH ( p = 0.142).

The si-CCNE1 and cisplatin (60 μg/kg) with an atelocollagen group showed a trend of decreasing tumor weight compared with the si-control and cisplatin (60 μg/kg) group (274.3 ± 136.4 vs. 420.6 ± 216.4, p = 0.191) ( Figure 7 B). 3.

Under conditions of endotoxemia, the levels of membrane-bound Gal3 statistically decreased in all the immune cell subsets with the exception of CD8 + T-cells, CD4 + T-cells, and DCs, which only showed a trend ( p = 0.2, p = 0.056 and p = 0.056, respectively) to a reduction of levels of Gal3 after the LPS exposure ( Figure 2 ).

Results Patients showed lower myostatin values (978.48 ± 805.84 pg/mL) than controls (1440.89 ± 479.62 pg/mL, Z = 3.80; p < 0.001, Figure 1 ), although patients with cirrhosis showed a nonsignificant trend to higher values (996.10 ± 810.13 pg/mL) than patients without cirrhosis (963.61 ± 814.86 pg/mL; Z = 0.24; p > 0.20; NS).

Variables with borderline significance ( p < 0.2) on the univariate analysis were subjected to multivariate regression analyses.

On the other hand, rs4714384 CT showed a trend toward association ( p < 0.200) but did not reach significance levels.