Excerpts

p -values of less than 0.05 and 0.01 were defined as significant and extremely significant, respectively. 5.

In the context of DDR after UV treatment, we observed an overall trend for decreasing gene transcripts when DNA damage was induced either during minor EGA (D2 embryos) or major EGA (D4 embryos) stages.

In this study, the MsRCI2D,-E genes in alfalfa could respond to salt and alkali stress and be regulated by ABA; the expression levels of the MsRCI2D,-E genes in roots and leaves showed an overall trend first increasing and then decreasing, but the up-regulation of the MsRCI2E gene was more rapid than that of the MsRCI2D gene ( Figure 2 ).

sFlt1 -transfected mice showed a trend towards an increased F4/80-positive area in the outer medulla compared to control IRI mice, however, this was not significant ( Figure 4 A,B; p = 0.554).

Based on the integration analysis of transcriptome and metabolome, the expression level of MYB21 (GH_D12G1622) showed a trend consistent with the content of Cyanidin-3-O-glucoside in the white and pink petals ( Table S11 and Figure S4B ).

A * p -value < 0.05 was regarded as significant, whereas a ** p -value < 0.01 and *** p -value < 0.001 were highly significant. 5.

Tomato ( Solanum lycopersicum L.) is a model plant for studying fleshy fruits and highly significant vegetable crops grown worldwide [ 18 ].

DA levels showed a trend toward a decrease (~35%) in both SR and SS rats ( Figure 3 a) in comparison to CT rats.

We speculate that the difference may be significant with more patients.

The metabolites selected are highly significant and are directly or indirectly related to inflammation. 2.2.1.

Shared and Distinct Changes in Expression of YAP/TAZ/TEAD Target Genes in Response to Hypoxia in Luminal and Basal A Breast Cancer Cells The response of three known YAP/TAZ target genes (CYR61, AXL, CTGF) to hypoxia in two luminal and two basal A TNBC cell lines showed an overall trend of increased expression in hypoxia, with CTGF being significantly enhanced in basal A but not luminal cells ( Figure 2 E).

Even the relatively high share of post-acrosomal cells among Gpx4 +/U46A + Alox15 −/− sperm was increased by calcium ionophore treatment ( p = 0.064) although the difference showed only borderline significance.

Presently, infections by antibiotic-resistant bacteria show an increasing trend, making antibiotic resistance a global health emergency and one of the major threats to human (and animal) health.

GA1 content illustrated the opposite trend to ABA content, which showed a trend of first increasing (S0 to S1) and then decreasing, with the lowest value found at S3.

The metabolites and associated pathways identified in this exploratory study serve as baseline for designing targeted metabolomic analyses, considering the highly significant p -values observed, which may suggest a relevant role of these metabolites in the pathophysiology of the disease.

51 placebo-treated patients; they found that the insulin releasing drug liraglutide, administered at 1.8 mg/d for 26 weeks, had virtually no effect on FDG uptake in the carotids and ascending aorta, albeit an exploratory analysis suggested a borderline significant effect in individuals with a history of CVD [ 46 ].

The trial showed a statistically significant decrease in the risk of hospitalization with an absolute risk reduction (ARR) of 11.7%, a borderline significant reduction in oxygen supplementation, a non-significant decrease in all causes of mortality, and no indication of harm associated with the treatment.

Compared to the differentiated group without stimulant treatment, the extracellular matrix of hMSCs incubated for 28 days with modafinil ( Figure 2 C), atomoxetine ( Figure 2 D) and guanfacine ( Figure 2 E) displayed a highly significant decreased amount of red calcium nodules under light microscopic evaluation and quantification.

Several SNPs showing a strong association (but without genome-wide significance) and one SNP (rs2074633 in HDAC9 gene) with borderline significance were identified [ 17 , 36 , 37 , 87 ].

We found a positive trend in SARS-CoV-2 RNA as detected by both tests (RT-qPCR and RT-ddPCR) in male compared to female newborns ( Table 2 ).

The effect of the tested substances on tumor growth, CAM thickness, and neoangiogenesis showed a trend towards SF8628 being more sensitive to NaDCA than PBT24.

In this study, the expression levels of apaf-1 and bax showed a trend of increasing and then decreasing expression, suggesting that H 2 O 2 -induced apoptosis may be more closely related to the mitochondrial pathway.

Next, the H3K4me 3 levels in the PPARG locus in TRIB3-KD cells were compared to Sh-control cells by ChIP-RT-qPCR, and the results showed a trend of increased H3K4me 3 levels upon TRIB3 downregulation ( Figure 5 B).

Interestingly, CpMAX1a expression showed an increasing trend again at 24 h ( Figure 4 E).

Statistical Analysis Data were analyzed by one-way analysis of variance (ANOVA) and Duncan’s test using IBM SPSS 22 software (SPSS, Chicago, IL, USA) and GraphPad Prism 8 (Insightful Science, Republic of Chile), for which p < 0.05 and p < 0.01 were considered statistically significant and highly significant, respectively.