Excerpts

Conversely, in LAVA, the correlations between these traits were only marginally significant and did not survive correction for pairwise testing ( p = 1.43 × 10 −3 , see Figure 3 and Supplementary Table S31 ).

In the SM group of patients, this allele is also more prevalent, but the association did not reach statistical significance ( p = 0.001482, Table 2 ).

This differential response was highly significant ( p = 0.0015). 2.6.

Statistical analysis confirmed a highly significant difference between the particle sizes of the three batches, ensuring a reliable size-related comparison for examining their effects on platelets in PRP ( p = 0.0016 and 0.0006 comparing PS of batch 1 and 2 with batches 2 and 3, respectively).

have quantitatively analyzed the molecular interaction between SUN proteins and Lamin A using acceptor photobleaching FRET technology, showing that the FRET efficiency of SUN1 and Lamin A (about 14–16%) is significantly higher than that of SUN2 and Lamin A (about 8–10%), and the difference between the two was statistically highly significant ( p = 0.0017) [ 6 ].

Our network-based statistics (NBS) analysis including 94 brain regions of the Allen Brain Atlas (atlas.brain-map.org, regions illustrated in Figure 1 B) provides evidence for a highly significant ( p < 0.002) increase of functional connectivity (FC) on the whole-brain network level in the Mct8/Oatp1c1 DKO group compared to WT mice ( Figure 3 A, primary threshold of p pt < 0.01, NBS permutation test with 5.000 runs and p NBS < 0.025).

A highly significant ( p = 0.002) difference of EMA expression depending on the latency of the first passage could be identified, with high EMA expression corresponding to an early passage in average after 7 days (range 5–10 days).

The results of the urinary creatinine measurement were very similar to the results of UcysC with enhanced age-dependent excretion in the Col8 -ko, which was also reflected in a highly significant genotype–age interaction ( p = 0.002) ( Figure 3 b).

The total intensity variation of telomeres between both surgeries in group-2 patients was highly significant ( p = 0.002) but it was not so significant in group-1 patients ( p = 0.08). 2.4.3.

This list shows highly significant overlap with disease-associated DEGs ( p -value = 0.002, representation factor 2.5).

The analysis of steroid levels in patients showed the following trends: Unconjugated steroids: A strong trend towards lower levels was found (n = 12 lower, n = 6 unchanged, n = 1 higher, p = 0.002).

This difference was highly significant in the noninfected plants ( p = 0.002). 2.6.

Similar results were also observed in the recessive model, where an 85% reduction in the odds of melanoma (OR 0.15, 95% CI: 0.06, 0.33, p < 0.001) was observed for rs8031 ( SOD2 ) with TT minor alleles, and a 91% reduction (OR 0.09, 95% CI: 0.01, 0.33, p = 0.002 with marginal significance) for rs2536512 ( SOD3 ) with AA minor alleles. 2.4.

We tested for overall differences among the subtypes with PERMANOVA, with highly significant results ( p = 0.002).

Highly significant differences were found in 25(OH)D concentrations of women with preeclampsia and the controls (14.75 vs. 22.10 ng/mL, p = 0.0021).

These effects could also be validated in HUVECs in vitro, as cells overexpressing miRNA-26b show a highly significant ( p = 0.0022) twofold induction of Cx40 transcription, compared to cells transfected with a non-coding siRNA (siNC) ( Figure 1 b).

In primary rat liver hepatocytes, MPEP dose-dependently reduced ATP concentration, producing a near-significant effect at 3 μM and a markedly significant effect at 30 μM ( p = 0.003).

392.2 ± 16.3 g, p < 0.001); the pre-EMPA + DOX group (group V) showed a trend towards weight loss over the longer 28-day period (422.4 ± 13.7 g vs. 395.7 ± 15.6 g, p = 0.003).

A highly significant ( p < 0.003) interaction between the action of SP and ThDP on the NAD(P)H:XTT reductase activity, is also revealed in the control A549 wt cells ( Figure 4 A,D).

Among these miRNAs, downregulation of miRNA-215 expression was highly significant in the STOP-IM group (plasma miRNAs, p = 0.00311 ( Table S1 ); exosomal miRNAs, p = 0.00039 ( Table S2 )); therefore, we concluded that plasma miR-215 expression mirrors exosomal miRNA expression and focused on expression of this miRNA for further study. 2.2.

Although differences were small and statistically insignificant during the early phase (Day 3–6, p > 0.05), the effect became significant on Day 10 ( p = 2.93 × 10 −2 ) and highly significant on Days 13 ( p = 3.25 × 10 −3 ) and 14 ( p = 1.69 × 10 −5 ).

Comparison of NGS and ddPCR results showed a highly significant correlation (ρ = 0.6047; p = 0.0036; Figure 5 A,B).

The ACTH level in blood ( Figure 2 b) also showed a trend to increase (F(1,30) = 9.62, p = 0.004), though the increase was significant in MCAO-LM only (MCAO-KM vs.

The M2 marker, MRC1/CD206, showed a highly significant impact for TGFB2 in this multivariate context (HR (95% CI) = 2.53 (1.35–4.73), p = 0.004) and a borderline significant impact for MRC1/CD206 (HR (95% CI) = 1.87 (1–3.51), p = 0.051).

In particular, the gintonin (GT 100)-treated group showed a trend similar to that of the ranitidine-treated group ( p = 0.004, Cohen’s d = 2.1 and p = 0.024, Cohen’s d = 1.5, respectively), in which the blood vessels were close to those of the normal group.