Excerpts

A recent meta-analysis showed a highly significant reduction in cardiovascular risk factors such as systolic and diastolic blood pressure associated with T2DM.

However, although there was a clear trend supporting left vs. right asymmetries in radiotracer uptake ( Figure 3 ) when compared to baseline levels, observed differences failed to reach statistical significance. 2.2.2.

The pro-inflammatory cytokine IL-17a showed a trend for up-regulation with the TRP-deficient diet compared to both the control and TRP-rich diets ( Figure 6 ).

The assessment of the impact of free BA, and the nanocomplexes on mitochondrial membrane potential revealed highly significant membrane depolarizations by T-Au-PEG-BA and T-Au[PLL-g-PEG]-BA compared to the untargeted (Au-PEG-BA and Au-[PLL-g-PEG]-BA), and free BA, highlighting the efficacy of this targeted approach.

The main current applications of different types of MSCs for therapeutic uses derive from the highly significant pro-regenerative and immune-modulatory paracrine effects [ 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ].

However, although an increasing trend was identified in a cohort from India [ 56 ], several studies report a decrease on K65R levels over the years in other countries [ 48 , 57 , 58 , 59 , 60 ].

The most common mutation across the years was M184V ( Figure 1 ), notwithstanding a decreasing trend and a significant decrease between 2015 (68.29%, n = 1874) and 2016 (53.21%, n = 2684) ( p < 0.001) ( Table 2 ).

Ammanuel and colleagues found that in patients with RTT ( n = 10) the power of 35–45 Hz oscillations during slow wave sleep (SWS) did not follow a typical and highly significant decrease from 2–5 to 6–9 years of age, suggesting that subjects with RTT do not exhibit a normal developmental reduction in cortical excitability [ 141 ].

Evaluation of vascularised and hypersprouting areas revealed that a knock-out of the WWC2 gene leads to a slight decrease of vascularised area compared to total retinal area and to a clear and highly significant increase of hypersprouting area compared to both total retinal area and vascularised area ( Figure 3 ).

Plasma and WAT levels of adiponectin showed a clear trend of negative correlation ( Figure S5C ).

The results of qRT-PCR analysis confirmed that the mRNA levels of four of these genes were significantly higher in high-5HT animals compared with low-5HT animals, and one of these genes ( Adipor2 ) showed a nonsignificant trend in the same direction as in the array data ( Figure 7 C–G). 3.

Additionally, the interaction observed during the simulation between the TX core of FLTX2 with Phe404 ( Figure 4 B) is quite significant since it is observed around more than 50% of the simulation time in the selected trajectory ( Supplementary Figure S7 ).

Cells exposed to TiO 2 for 13 weeks showed a trend of shorter telomere length at both doses compared with Ctrl ( Figure 4 ).

Similarly, two other studies have shown that the interference of nanomaterials with flow cytometry assays is dose-dependent and is more likely to be significant at higher concentrations [ 50 , 51 ].

While the flies are closer to controls at 21 days than at 14 days, there are still highly significant differences in gene expression ( Figure 2 C).

It was found that the proton conductivity of composite membranes containing PA/PBI, PA/PMC 6 /PBI, and PA/PDC 3 /PBI demonstrated an increasing trend by increasing the temperature up to 180 °C.

The results illustrated that the conductivity of membranes was increased by raising the temperature from 30 to 90 °C, although pristine SPEEK membrane showed a decreasing trend by increasing temperature.

Analysis of the mostly highly significant putative upstream regulators was based upon an activation z-score and statistically significant ‘overlap p -values’ in IPA ( p < 0.01).

On the contrary, the injured animals treated with vehicle at 35 dpi showed a trend towards a slight improvement that was highlighted by a decrease in significance with respect to the control group in the paw reaching task that would be induced by the rehabilitation therapy itself.

They found that the microorganisms, metabolites in GCF, and clinical data combined showed a clear trend, and clinical data regarding periodontitis could be reflected in the shift of the oral microbial community and the change in metabolites in GCF.

The visceral fat area and apo B/apo A1 ratio also displayed a decreasing trend, indicating that CGJ exerted an anti-atherogenic effect.

Thus, these results imply that CD40 expressed with IDO may be significant to the immune capacity of T-MSCs.

However, 27 proteins characteristic for neutrophils were found more up-regulated upon injury in adult than in fetal animals with marginal significance ( Table 1 ), supporting histological assessment.

A decreasing trend of MEF2A protein level was detected in G93A-SOD1 mice compared to that of controls, but it did not reach statistical significance.

In line with gene expression data, no significant results were obtained for PAX7 expression in G93A-SOD1 compared to that of control mice, although the protein showed an increasing trend with disease progression (as illustrated in Figure 3 A).