Barely Significant

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In comparison with the NC group, the relative abundance of three phyla (i.e., Firmicutes, Proteobacteria, and Actinobacteriota) in the PC group showed an increasing trend, while the relative abundance of the other two phyla (i.e., Bacteroidota and Euryarchaeota) showed a decreasing trend.
coli showed a trend that increased by 13.2% (95%CI: 6.1–20.2) in clinical blood specimens, 8.1% (95%CI: 1.7–14.4) in all clinical specimens and 17.7% (95%CI: 4.9–30.4) increase in carriage specimens.
Surveillance of community-acquired infections has reported a widespread ESBL-mediated resistance and has shown an increasing trend for 10 years ( Kanoksil et al., 2013 ; Fox-Lewis et al., 2018 ; Chang et al., 2020 ).
The average RMSD for M429I was 0.65Å; however, an increasing trend was reported – for instance, a previous study reported that mutations with increasing instability produce the function of radical protein, implying that these mutations have evolved with radical function and have increased infectivity ( Hussain et al., 2020 ).
Although only a trend toward significance in our study for racial disparity in COVID-19 was observed, a large systematic review involving 50 studies from the United States and United Kingdom concluded that individuals of black and Asian ethnicities have a higher risk of contracting COVID-19 in general, and more specifically, Asians were at a higher risk of hospital admission and death ( Sze et al., 2020 ).
In this study, aside from the poor bactericidal activity observed amongst the co-producers, we were unable to identify a clear trend among the isolates with the other carbapenemase types, indicating that the knowledge of carbapenemase types alone was a poor indicator of combination activity in our isolates.
Among the selected secondary metabolites, the levels of ginsenosides, including ginsenoside-Rb1, Rb2, Rc, Rd., Rf, ginsenoside-Rg2, Rh1, and notoginsenoside-R1, -R2, and -R4 showed a decreasing trend, whereas the levels of ginsenoside-Rg3 and glucoginsenoside-Rf showed an increasing trend.