Barely Significant

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The bacterial, fungal, and total microbial residue carbon all showed a decreasing trend of 60%ON > 50%ON > 40%ON > CK with the reduction of organic nitrogen content: at the HT site, all three organic nitrogen treatments were significantly higher than the CK; at the LY site, there were significant differences among the 60%ON, 50%ON, and 40%ON treatments, but no significant difference was found between the 40%ON treatment and CK ( Supplementary Figure S1 ). 3.4 Soil microbial community diversity and structure The application of organic nitrogen increased soil microbial diversity at both experimental sites.
There is an increasing trend that more and more novel toxic and harmful species have been described, which cause HABs suddenly and draw great attention from the research community ( Benico et al., 2020 ; Cen et al., 2020 ; Gu et al., 2022 ; Hu et al., 2021 ; Wolny et al., 2025 ).
This discrepancy may stem from several factors: (1) Patient and infection complexity: Randomized controlled trial (RCT) populations exhibit high heterogeneity, and the complexity of infections (such as endocarditis and deep-seated abscesses) far exceeds that of standardized laboratory models; (2) Suboptimal dosing regimens: The dosing regimens used in trials may fail to achieve the PK/PD targets required for synergy at the infection site; (3) Adverse events (AEs): The meta-analysis revealed a nonsignificant trend toward greater treatment discontinuation due to AEs in the combination arms, which may have potentially confounded the efficacy assessment.
highly significantqualifiedgold
Whereas we found a highly significant reduction of Cladosporium bacteria in DS under high-salt conditions compared to other treatments, and a relatively high abundance of Pleotrichocladium bacteria was found in DS, which has recently been associated with enhanced drought resistance, salinity tolerance, and may be useful in the treatment of serious health problems such as neurodegenerative diseases and antibiotic resistance ( Rodríguez Martín-Aragón et al., 2023 ; Xu et al., 2024 ).
highly significantqualifiedgold
In week 5 post-treatment, the highly significant treatment effect was evident, with AM + CA + MO + PFA (4.8 eggs), AM + NG + MO + PFA (4.8 eggs), and AM + RC + MO + PFA (4.9 eggs) treatments emerging as the most effective treatments.