Excerpts

When we pooled the data from two cohorts, however, statistical differences between the RRMS ( n = 41) and HC ( n = 44) groups were highly significant (Figure 2 C).

In contrast, 5/12 genes showed significant or near-significant sinusoid-like temporal (PP-independent) expression trends (Figure 7 A) of modest effect size (η 2 = 5–9%) (Table 4 ).

We observed that the neutralizing potential of the Abs in the serum was already highly significant on day 7 post i.v.; it increased further on day 14 and remained at the same high level until at least day 28, the last day tested (Figure 5 A).

We correlated results between the two platforms and found highly significant correlation with r 2 = 0.926 (Figure 1 D).

Under these conditions, illumination periods of 5 min and more resulted in a strong and highly significant increase in CD8+ T cell activation, which again decreased with illumination times of more than 12 min.

Analysis of CD4 + and CD8 + T-cell populations in the spleen as a comparison showed a trend toward lower levels of CD8 + T cells in young females that reached significance in the middle age (Figure S4A in Supplementary Material).

We observed an interesting trend that the frequency of antigen-specific binding increased with up to 3 mutations in the VH region but did not increase from 3 to 10 average mutations.

In addition, NOD mice treated with CYP alone showed a trend towards reduction of T cells and effector memory T cells (not statistically significant; Figures 1 C,D).

The beta diversity, however, accessed by using Jensen–Shannon divergence, showed a trend for reduction after changing to the short-vegetarian diet, and reached significance at the genus and species level (A vs.

However, we observed a positive trend between the level of fatigue and NKT-like cells (CD3 + CD16 +/− CD56 + ) (rho = 0.30), and a negative trend between the percentage of fatigue vs pain and NKG2C expression (rho = −0.33) (Figures S4B,C in Supplementary Material).

Patients receiving a kidney with at least one G allele for the CD46 promoter polymorphism rs2796267 (A/G) showed a lower rejection-free survival, though this became borderline significant after adjustment for potential confounders (aHR 1.87, 95% CI 0.96–3.65).

Flow cytometry analysis of mice splenocytes revealed a highly significant decrease in the percentage of CD4 + Foxp3 + Tregs from 59.6 to 1.39% following C36L1 treatment (Figure S6B in Supplementary Material).

The score obtained for this prediction is highly significant (TM-score = 0.98), indicating the robustness of the prediction, as well as a structural alignment conservation with the AgTEP1 reference despite a low similarity at the amino-acid level (29%) (Figure 1 B).

In our cohort of IFN-β-treated patients, serum levels of IL-37 appeared as an increasing trend compared to untreated patients [3.38 (IQR: 2.51–4.68) vs 3.04 (IQR: 2.59–6.01)] and the same relationship was found for TGF-β1 [27,871.75 (IQR: 22,672.83−32,873.73) vs 21985.20 (IQR: 19,425.04–33,815.69)].

Our observations indicate an increasing trend corresponding to log2 mean intensities, with a ~13-fold difference between 5e5 and 5e6, a ~97-fold difference between 5e5 and 5e7, and a ~7-fold change between 5e6 and 5e7.

Anti-CD37 antibody also showed a trend toward the inhibition of SGC formation in Cl and NCl monocytes.

Blocking Mφ with anti-CD11b, NK with anti-CD314, and B cells with anti-sIgM in SC from naïve and AA mice showed borderline significant MDSC-Exo uptake inhibition, which was alike in naïve and AA LNC (data not shown).

In mice with AA totalis, the impact of MDSC-Exo application became significant after 6 weeks of treatment and was highly significant after 10 and 16 weeks, i.e., was maintained and even slightly improved 6 weeks after treatment termination (Figure 8 A).

Moreover, BRCA1 rs12516 CC genotype had a significantly higher BRCA1 protein expression, compared to CT/TT variant genotypes and RAD51 rs7180135 AA genotype had a borderline significant association to a higher expression of RAD51 protein, compared to RAD51 rs7180135 AG/GG variant genotypes.

However, the expression of VCAM-1 was found to be similar in BE and duodenum, and this expression was significantly higher or almost reached significance compared to most SQ groups of RE/BE patients and controls (Figure 2 ).

The reduction in the length distribution width is highly significant.

Stimulating B cells with R848 (TLR7/8 agonist) and IFNα showed a trend toward an increase in the percentage of CD19 + CD24 hi CD38 hi cells from CHC, but not in active on-treatment JDM patients [with PGA > 3.5 (range 0–10)] (Figures S5A,B in Supplementary Material).

Still, we detected a clear trend of reduced CD38 hi IgM − plasmablasts (measured as a percent of B cells in 12 patients: normal in 3 patients, reduced in 7, absent in 2, and an increased in none) and a relative increase of CD21 low CD38 low (activated) B cells in 6 of 12 patients across all three genotypes analyzed (Table 3 ).

This information is highly significant, because representative viruses from these lineages demonstrate differential neuroinvasive and inflammatory capabilities, as well as different infection profiles.

However, this effect was only marginally significant and requires further investigation.