Excerpts

There was a mild trend towards lower CXCL4 release in macrophages from MyD88 -/- mice treated with LPS alone or together with long-chain polyphosphates when compared to WT mice ( Figure 2C ).

There was a clear trend that PCB alone was able to inhibit the proliferation of MBP-stimulated rat T MBP-GFP cells dose-dependently.

The expression of PD-1 on CD4 + T and CD8 + T cells in spleen and peripheral blood showed an increasing trend.

In particular, the HR showed an increasing trend from univariate Cox regression analysis to multivariate Cox regression analysis.

Similarly, the qRT-PCR results of CHKB and PEMT showed a trend consistent with Western blot ( Figures 13J, K ).

Firmicutes showed a decreasing trend (0%–0.9%) and then increased (0.9%–1.2%) with increasing dietary cysteine content.

Subsequently, the mRNA expression levels of cytokines were quantified in L8824 cells after incubation with the different Hb preparations and heme, and this revealed that the expression of pro-inflammatory cytokines was almost significantly upregulated in heme- and Hb-Fe 4+ -treated cells, especially at 24 h.

Correlations of MΦ PC1 composite scores with ACTA2 , PDCD1LG2 , TNFAIP6 , ANGPT1 , and CXCL8 were near-significant.

Consistent with the above results, based on the analysis of GEO dataset analysis, the GSE16011 dataset showed an increasing trend in the number of patients with high-grade glioma ( Figure 4E ); similar results were observed for the GSE4412 dataset ( Figure 4F ) and the GSE43289 dataset ( Figure 4G ). qRT–PCR and immunohistochemistry (IHC) staining for SLC11A1 were used to evaluate SLC11A1 expression in tumor tissue samples and for further validation.

There was a strong trend towards a lower cytokine level in RvD2 treated mice, but only IL-23 levels were significantly lower.

To further validate the signature, we applied it to the testing group and all samples, and the results showed a trend consistent with the training group ( Figures 5B–E ).

After co-culture with OA-FLS, M2 Mφs showed a trend of transition to the M1 phenotype, with decreased polarization markers of M2 (CD206, ARG1).

In the Phase Ib study KEYNOTE-524, the combination of lenvatinib and pembrolizumab achieved an ORR of unresectable HCC of 36.0% ( 114 ), but its Phase III trial LEAP-002 did not reach the primary end point of the study, but showed a trend toward beneficial activity.

There was a nominally significant association between CD28 expression on CD4+ T cells and response (CR or PR) at day 180 after CAR-T cell infusion (91.3% CD28+, range 56.9–99.9% for responders versus 79.4%, range 44.6–99.9% for non-responders, p=0.048, t-test), but no other statistically significant associations between clinical outcomes and the frequencies of immune cell subsets in PBMC samples or the infusion products.

Due to the deterioration of the environment and the increase in the aging population, the incidence rate of IPF also shows an increasing trend every year ( 6 , 7 ).

We found a highly significant inverse correlation between MBL and fat percentage, determined by a whole-body DEXA scan, a very precise expression for obesity.

Conversely, OAS3a was elevated in the cornea of WT mice in comparison to OPN KO animals although it did not quite reach significance ( Figure 2F ).

In addition, IL-15 showed a trend to increase in patients that had severe disease and recovered, as compared to those in the Mild group ( Figure 3C ) .

Additionally, a notable trend in recent years has been to solve TCR:pMHC complexes that ‘break the rules’ rather than adhere to them ( 48 ), which may interfere with interpretability of the properties of our ‘representative TCRs’ as reflective of typical TCR behavior.

Interestingly, flow cytometric analysis showed a trend towards lower T cell infiltration in both groups receiving combined treatment with tumor vaccination and SUREK trAb with or without administration of Pd-1 blocking antibody ( Supplementary Figures 6A, B ).

P < 0.05 and < 0.01 were considered significant and extremely significant, respectively. 3.

This may be significant as ligation of CD180 induces affinity maturation and programs immature (including T1) and mature B cell subsets to become efficient antigen presenting cells to T follicular helper cells ( 81 , 82 ).

Further, expression of the Th1 marker, CXCR3, on blood γδ T cells, NKT cells, and CD8T cells showed a trend of early increase that was significant at week-3 post-BCG ( Figure 4C ).

The other genes, such as STAT4, IL-12A, IL-12RB, BACH2 and CTLA-4/CD28, were described as nominally significant ( 2 ).

In addition, the levels of severity showed a clear trend from less to more severe ( Figure 1B ).