Excerpts

However, the Authors argue that there might be significant differences in the studio populations.

Time-dependent leakage (Ktrans) measurements demonstrated an increasing trend prior to POD between T-1 and T-2 time points; however, the opposite was observed between T-2 and T-3.

[ 12 ] did not significantly differ in this study but showed a trend toward higher financial toxicity.

In a multivariate regression analysis, a GLR > 92.72 [hazard ratio (HR) = 2.475, 95% confidence interval (CI): 1.502–4.078, p < 0.001] was identified as an independent predictors of long-term DSS prognosis, while CA19-9 > 145.35 U/mL (HR = 1.577, 95% CI: 0.966–2.572, p = 0.068) and the presence of symptoms (HR = 1.582, 95% CI: 0.974–2.568, p = 0.064) were expected to be marginally significant independent predictors of DSS prognosis ( Table 2 , Figure 1 ).

AML cases showed a trend of correlation of NCAM1 with fibrosis, but case numbers were too low for statistical analysis. 3.2.

A trend toward significance revealed higher local control (LC) rates in patients with a duration of symptoms lasting less than four months from the onset of the disease to the initial consultation (97.7% vs. 84.3%; p = 0.061).

Interestingly, our group of patients with no re-resection radiotherapy showed a trend towards a higher rate of LR.

The XELOXA trial comparing 5-FU to a combination of CAPOX showed a trend toward benefit from the addition of oxaliplatin in terms of DFS and OS in elderly patients, although this was diminished compared to younger patients and was not statistically significant [ 66 , 67 ].

Sixty-seven percent of cases are now diagnosed incidentally [ 4 ], resulting in a decreasing trend in tumor size and stage [ 5 ].

There was also a clear trend toward less positive findings in papillary and chromophobe RCC cases.

Over the past decade, there has been an increasing trend toward the use of DECT for the evaluation of renal lesions [ 17 , 22 , 23 , 24 ].

Charlson-Deyo comorbidity score groups of 1 (HR 1.22, 95% CI 1.06–1.41), 2 (HR 1.8, 95% CI 1.47–2.22), and 3 or more (HR 2.46, 95% CI 1.94–3.12) were associated with statistically significantly worse OS compared with the score 0 group, demonstrating a clear trend of decreasing survival as the comorbidity score increased.

The peak dose shows a decreasing trend over depth with local rises in the bone, which are observed in the valley dose as well.

There was no significant association between the other exposures related to contraception, parity, menopause, hormone replacement therapy, and fertility with all-cause mortality across the survival time intervals; however, there was a marginally significant association between age at menarche >14 years old and mortality in the intermediate survival interval of 6 to <10 years compared to age at menarche ≤12 years old (HR 1.60; 95% CI 1.01, 2.52; p < 0.05).

Furthermore, males exhibited an increasing trend in stress as treatment progressed, whereas females showed a decreasing trend.

Conclusions Similar to studies in primary brain tumors, we found a qualitative attenuation of the BOLD signal in the metastasis-affected hemisphere compared to the contralateral hemisphere, as well as considerably significant changes in functional connectivity (FC) in the presence of BM in this study.

A decreasing trend was described by the degree of dysplasia with a sensitivity of 48%, 43%, and 27% for CIN3 in the ASCUS, LSIL, and NILM groups, respectively [ 9 ].

A further subpopulation analysis, including 70 patients (85%) without metastases at presentation, revealed that rWIR as a binary variable nearly approached significance, suggesting an association with EFS (HR: 2.3; 95% CI: 1.0–5.2) ( Table 3 ). rWIR as a continuous variable was significantly associated with EFS (HR: 0.7; 95% CI: 0.5–0.9).

In general, 40% of patients receiving curative chemoradiation failed to return to work after treatment, but patients randomized to IMPT were more able to keep on working and demonstrated a favorable trend toward higher productivity recovery levels.

In addition, a positive trend was reported in pain management in terms of VAS scores.

There is an increasing trend towards regulated, protocol-driven oncological fertility care programs [ 16 , 17 ].

Among these, the steepest dose–response was reported for meningioma, with an increasing trend in individuals exposed at younger ages [ 43 ], emphasizing the relevance of even small absolute differences in dose.

Specifically, the Hazard Ratios (HRs) for mean nuclei sizes indicate a clear trend: larger nuclei sizes are associated with a higher risk of adverse outcomes, highlighting the prognostic value of nuclear morphology in melanoma.

Multivariate analysis also showed a trend for a relationship between PS and liver function with OS.

pylori -positive group showed a trend toward a 4-month longer median immune-related overall survival (irOS).